2015
DOI: 10.2337/dc15-0851
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Increased All-Cause Mortality in Patients With Type 1 Diabetes and High-Expression Mannan-Binding Lectin Genotypes: A 12-Year Follow-up Study

Abstract: OBJECTIVEMannan-binding lectin (MBL) is a complement-activating carbohydrate-recognizing molecule associated with diabetic nephropathy. MBL is associated with all-cause mortality in type 2 diabetes, but whether MBL is associated with mortality in type 1 diabetes remains unknown. We therefore aimed to investigate this. RESEARCH DESIGN AND METHODSWe studied an existing 12-year prospective cohort with RESULTSNinety-eight patients died during follow-up. The unadjusted hazard ratio (HR) for all-cause mortality was… Show more

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Cited by 28 publications
(18 citation statements)
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“…Furthermore, serum levels of MBL are significantly elevated in patients with type 1 diabetes when comparing to healthy individuals [5, 28]. Furthermore, our group have recently described that all-cause mortality is strongly associated with MBL genotype and MBL concentration in type 1 diabetes [29]. …”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, serum levels of MBL are significantly elevated in patients with type 1 diabetes when comparing to healthy individuals [5, 28]. Furthermore, our group have recently described that all-cause mortality is strongly associated with MBL genotype and MBL concentration in type 1 diabetes [29]. …”
Section: Discussionmentioning
confidence: 99%
“…MBL levels are elevated in both patients with type 1 diabetes and type 2 diabetes , and in the last decade increased MBL and ficolin levels have, in a number of prospective studies, been associated with cardiovascular morbidity and mortality in diabetes . Circulating levels of MBL are mainly determined genetically , and the MBL2 genotype with the highest level of MBL is associated with mortality in type 1 diabetes . Compared to MBL, the role of MASPs in diabetes remains less explored.…”
Section: Introductionmentioning
confidence: 99%
“…Clinical observations through the last decade link the complement-activating carbohydrate-recognizing molecule mannan-binding lectin (MBL) to diabetic kidney disease [ 4 9 ]. In addition, we have recently described that the concentration-determining MBL genotype is tightly associated with mortality in type 1 diabetes patients [ 10 ]. Animal studies indicate a causal role of MBL in this association as MBL knockout mice are resistant to diabetic kidney changes [ 11 , 12 ].…”
Section: Introductionmentioning
confidence: 99%