Increased angiogenin expression in gastric cancer correlated with cancer progression

Shimoyama, Shouji; Kaminishi, Michio

doi:10.1007/s004320000138

Cited by 111 publications

(148 citation statements)

References 28 publications

Supporting

Mentioning

139

Contrasting

Unclassified

Order By: Relevance

“…Systemic angiogenin levels can increase as a part of an acute phase reaction, 16,17 and we therefore investigated whether systemic angiogenin levels were altered in cytopenic patients with complicating bacterial infections. These studies included both induction and consolidation cycles, but due to the absence of blast excess in the bone marrow, it is unlikely that residual leukemic disease should have any major influence on the results for patients receiving induction therapy.…”

Section: Discussionmentioning

confidence: 99%

“…8 -14 Angiogenin normally circulates in human serum, and its systemic levels can be upregulated as a part of the acute phase reaction. 15,16 Increased serum angiogenin levels have also been detected for patients with solid tumors as well as bone marrow infiltrating hematologic malignancies, [17][18][19][20][21][22][23] and increased angiogenin expression in tumor-surrounding tissue seems to contribute to this increase. 24 Basic fibroblast growth factor (bFGF) is another proangiogenic regulator that also has a direct effect on endothelial cells.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Serum levels of angiogenin, basic fibroblast growth factor and endostatin in patients receiving intensive chemotherapy for acute myelogenous leukemia

Glenjen

Mosevoll

Bruserud

2002

Intl Journal of Cancer

View full text Add to dashboard Cite

Angiogenesis seems to be important both in the pathogenesis of acute myelogenous leukemia (AML) and for the susceptibility of AML blasts to chemotherapy. Recent clinical studies even suggest that antiangiogenic therapy can induce disease control in patients with AML relapse. In this context we have investigated the profile of the systemic component of angiogenic regulation in AML by characterizing the serum levels of (i) the angiogenic regulators angiogenin, basic fibroblast growth factor (bFGF) and endostatin; (ii) the endothelial cell marker soluble (s) E-selectin. Patients with untreated AML had increased levels of angiogenin, endostatin and sEselectin, whereas the levels of bFGF were not significantly altered. The systemic levels of the proangiogenic bFGF, the antiangiogenic endostatin and the endothelial cell marker sE-selectin showed significant correlations, whereas angiogenin and sE-selectin levels were not correlated. Furthermore, intensive chemotherapy resulted in decreased systemic levels of the 2 proangiogenic mediators angiogenin and bFGF, whereas endostatin levels remained high after treatment. Although angiogenin normally is a part of the acute phase reaction, its systemic levels were not altered when patients with chemotherapy-induced cytopenia developed complicating bacterial infections. Our results suggest that intensive chemotherapy can modulate the systemic component of angiogenic regulation in AML patients.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Serum levels of angiogenin, basic fibroblast growth factor and endostatin in patients receiving intensive chemotherapy for acute myelogenous leukemia

Glenjen

Mosevoll

Bruserud

2002

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…Various cell types including vascular endothelial cells, smooth muscle cells, fibroblasts, and lymphocytes are thought to express angiogenin (4,5). In addition, circulating angiogenin has been detected in normal serum (6,7).…”

Section: Introductionmentioning

confidence: 99%

Angiogenin expression in the sera and skin of patients with rheumatic diseases

et al. 2012

View full text Add to dashboard Cite

“…Angiogenin has been shown to play a role in tumor angiogenesis (4). Its expression is upregulated in many types of cancers (5)(6)(7)(8)(9)(10). Angiogenin undergoes nuclear translocation in endothelial cells, which has been shown to be necessary for angiogenesis (11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Influence of basic fibroblast growth factor on the growth of HeLa cells and the expression of angiogenin

Yang

Wang²,

Zhao³

et al. 2009

Oncol Rep

View full text Add to dashboard Cite

Abstract. Basic fibroblast growth factor (bFGF) is closely involved in angiogenesis and tumor growth of various cancers, but its role in cervical cancer remains to be defined. We investigated the effects of bFGF on HeLa cell growth and studied its influence on the expression of angiogenin. We transfected the bFGF gene in the sense and antisense orientation into HeLa cells, and obtained stable bFGF underexpressing and overexpressing transfectants. In our experiments, we demonstrated that inhibition of bFGF gene and protein expression in the bFGF antisense transfectants induced increased protein expression of angiogenin. In contrast, in the bFGF sense transfectants the expression of angiogenin decreased. Delivery of recombinant angiogenin into transfected and control cells led to increased proliferation in the bFGF antisense transfectants and the control cells. However, the cell proliferation had no change in the bFGF sense transfectants. In conclusion, we demonstrated that besides its angiogenic activity, bFGF and angiogenin also directly contribute to HeLa cell proliferation. Furthermore, endogenous bFGF affects the expression of angiogenin in HeLa cells. These findings suggest that inhibition of bFGF alone is not a promising strategy to inhibit angiogenesis. IntroductionCancer of the uterine cervix is the second most common cancer among women in the world (1), and the most common gynecological malignancy in P.R. China. Angiogenesis stimulates tumor growth, invasion and metastasis, and therefore is a crucial step in tumorigenesis. Further, evidence of increased neovascularization has been shown to be a negative prognostic indicator in many solid tumors, including cervical cancer (2). Several growth factors may be involved in the angiogenic process, including angiogenin and basic fibroblast growth factor (bFGF).Angiogenin is a 14-kDa angiogenic protein originally isolated from the conditioned medium of HT-29 human colon adenocarcinoma cells (3). Angiogenin has been shown to play a role in tumor angiogenesis (4). Its expression is upregulated in many types of cancers (5-10). Angiogenin undergoes nuclear translocation in endothelial cells, which has been shown to be necessary for angiogenesis (11-13). Tsuji et al have shown that nuclear translocation of angiogenin occurred in HeLa cells regardless of the cell confluence status, and that angiogenin stimulated rRNA synthesis in HeLa nuclei (14). Many studies have focused on how angiogenin induced tumor angiogenesis and how its angiogenic activity can be disrupted. Little, however, is known about its expression and function during HeLa cell growth.Basic fibroblast growth factor (bFGF), a member of a group of heparin-binding multifunctional polypeptides, is one of the most potent angiogenic factors (15,16). It is also involved in proliferation and differentiation of a variety of normal and malignant cells and tissues (17,18). Many malignant tumors showed an increase in bFGF expression (19)(20)(21)(22). Sliutz et al have demonstrated that serum basic fibroblast growth f...

show abstract

Increased angiogenin expression in gastric cancer correlated with cancer progression

Abstract: These results suggest that angiogenin expression is increased in GC and that the increased serum concentration in GC patients correlates with cancer progression.

Cited by 111 publications

References 28 publications

Serum levels of angiogenin, basic fibroblast growth factor and endostatin in patients receiving intensive chemotherapy for acute myelogenous leukemia

Serum levels of angiogenin, basic fibroblast growth factor and endostatin in patients receiving intensive chemotherapy for acute myelogenous leukemia

Angiogenin expression in the sera and skin of patients with rheumatic diseases

Influence of basic fibroblast growth factor on the growth of HeLa cells and the expression of angiogenin

Contact Info

Product

Resources

About