Increased antagonist muscle activity in cervical SCI patients suggests altered reciprocal inhibition during elbow contractions

Crémoux, Sylvain; Amarantini, David; Tallet, Jessica; Maso, Fabien Dal; Berton, Éric

doi:10.1016/j.clinph.2015.03.016

Cited by 12 publications

(10 citation statements)

References 55 publications

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“…The inability of adults with CP to suppress the soleus H-reflex to the same extent as healthy adults at the onset of dorsiflexion is similar to what has been observed in adults who have acquired lesion of descending motor pathways as adults because of multiple sclerosis [ 20 ], stroke [ 36 ], or spinal cord injury [ 37 , 38 ]. Our findings indicate that a similar impaired control in adults may also be seen as the result of a lesion early in life and that the intervening years of motor practice and experience apparently do little to change this.…”

Section: Discussionsupporting

confidence: 56%

Impaired Ability to Suppress Excitability of Antagonist Motoneurons at Onset of Dorsiflexion in Adults with Cerebral Palsy

2018

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We recently showed that impaired gait function in adults with cerebral palsy (CP) is associated with reduced rate of force development in ankle dorsiflexors. Here, we explore potential mechanisms. We investigated the suppression of antagonist excitability, calculated as the amount of soleus H-reflex depression at the onset of ankle dorsiflexion compared to rest, in 24 adults with CP (34.3 years, range 18–57; GMFCS 1.95, range 1–3) and 15 healthy, age-matched controls. Furthermore, the central common drive to dorsiflexor motoneurons during a static contraction in the two groups was examined by coherence analyses. The H-reflex was significantly reduced by 37% at the onset of dorsiflexion compared to rest in healthy adults (P < 0.001) but unchanged in adults with CP (P = 0.91). Also, the adults with CP had significantly less coherence. These findings suggest that the ability to suppress antagonist motoneuronal excitability at movement onset is impaired and that the central common drive during static contractions is reduced in adults with CP.

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Section: Discussionsupporting

confidence: 56%

Impaired Ability to Suppress Excitability of Antagonist Motoneurons at Onset of Dorsiflexion in Adults with Cerebral Palsy

2018

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“…The crosstalk and the simultaneous muscle activation is present as the target location is spread over the whole window and not only on the axes. This behaviour was observed in several subjects and can be related to the activation of antagonistic muscles detected in patients with SCI by Cremoux et al [19]. However, results are not conclusive and require further investigation.…”

Section: State Navigatormentioning

confidence: 70%

Myoelectric Gaming in the Rehabilitation of Patients with C7 Spinal Cord Injury

et al. 2019

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This paper analyses the role of myoelectric games in the rehabilitation of paraplegic patients. The University of Valladolid neuromuscular training system, UVa-NTS platform, which allows the myoelectric command of computer applications, has been introduced in rehabilitation sessions of a group of paraplegic patients. The experiments took place both at the University of Valladolid and at the National Hospital for Paraplegics of Toledo in Spain. A homogeneous population of five patients with a C7 spinal cord injury was compared with a group of control subjects. The myoelectric control was performed with the flexor carpi radialis and the extensor carpi radialis muscles. The myoelectric routines were timed and the game scores measured. Notwithstanding the reduced mobility of the patients, they achieved fast adaptation and better timings than the control subjects in the first experiment (p < 0.001), although this difference was reduced in further experiments. Both patients and control subjects played satisfactorily with the Myo-Pong game. However, the improvement in the scores was better for the control subjects between sessions (p = 0.009) when compared with the patients (p = 0.978). The results show that patients and control subjects were able to perform and reached similar scores. However, patients’ improvement in further rehabilitation sessions was lesser than when compared with the control subjects.

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“…Even though all participants exerted comparable net joint torque, our results revealed increased muscle co‐activation in the SCI group. This increase in muscle co‐activation mainly arises from increased antagonist muscles activation, as previously shown in participants with SCI during both electrically evoked and voluntary contractions (Thomas et al ., ; Cremoux et al ., ). Although necessary for data comparison, the normalization of EMG data revealed a supramaximal activation of elbow extensors when used as antagonist muscles (Cremoux et al ., ).…”

Section: Discussionmentioning

confidence: 97%

“…It takes an active part in joint stabilization according to the exerted force level (Baratta et al ., ; Solomonow et al ., ; Gribble et al ., ; Rao et al ., ; Amarantini & Bru, ). After SCI, increased muscle co‐activation may be caused by reduced influence of the cortical structures on the spinal mechanisms inhibiting antagonist muscles (Boorman et al ., ; Xia & Rymer, ), and especially altered reciprocal inhibition (Cremoux et al ., ). Therefore, the residual interactions between cortical and muscles’ activities may play a major role in the regulation of muscle co‐activation.…”

Section: Introductionmentioning

confidence: 99%

“…After spinal cord injury (SCI), the intensive reorganization of the neuromuscular system leads to increased antagonist muscles co-activation (Thomas et al, 1998;Cremoux et al, 2016). Muscle co-activation refers to the simultaneous activation of agonist and antagonist muscles, respectively, acting in and against the direction of the net joint torque (Kellis et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

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Impaired corticomuscular coherence during isometric elbow flexion contractions in humans with cervical spinal cord injury

Crémoux

Tallet

Maso

et al. 2017

Eur J of Neuroscience

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After spinal cord injury (SCI), the reorganization of the neuromuscular system leads to increased antagonist muscles' co-activation-that is, increased antagonist vs. agonist muscles activation ratio-during voluntary contractions. Increased muscle co-activation is supposed to result from reduced cortical influences on spinal mechanisms inhibiting antagonist muscles. The assessment of the residual interactions between cortical and muscles activity with corticomuscular coherence (CMC) in participants with SCI producing different force levels may shed new lights on the regulation of muscle co-activation. To achieve this aim, we compared the net joint torque, the muscle co-activation and the CMC ~ 10 and ~ 20 Hz with both agonist and antagonist muscles in participants with SCI and healthy participants performing actual isometric elbow flexion contractions at three force levels. For all participants, overall CMC and muscle co-activation decreased with the increase in the net joint torque, but only CMC ~ 10 Hz was correlated with muscle co-activation. Participants with SCI had greater muscle co-activation and lower CMC ~ 10 Hz, at the highest force levels. These results emphasize the importance of CMC as a mechanism that could take part in the modulation of muscle co-activation to maintain a specific force level. Lower CMC ~ 10 Hz in SCI participants may reflect the decreased cortical influence on spinal mechanisms, leading to increased muscle co-activation, although plasticity of the corticomuscular coupling seems to be preserved after SCI to modulate the force level. Clinically, the CMC may efficiently evaluate the residual integrity of the neuromuscular system after SCI and the effects of rehabilitation.

show abstract

Increased antagonist muscle activity in cervical SCI patients suggests altered reciprocal inhibition during elbow contractions

Cited by 12 publications

References 55 publications

Impaired Ability to Suppress Excitability of Antagonist Motoneurons at Onset of Dorsiflexion in Adults with Cerebral Palsy

Impaired Ability to Suppress Excitability of Antagonist Motoneurons at Onset of Dorsiflexion in Adults with Cerebral Palsy

Myoelectric Gaming in the Rehabilitation of Patients with C7 Spinal Cord Injury

Impaired corticomuscular coherence during isometric elbow flexion contractions in humans with cervical spinal cord injury

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