Increased Aortic Pulse Wave Velocity Is Associated With the Presence of Angiographic Coronary Artery Disease in Overweight and Obese Patients

Bechlioulis, Aris; Vakalis, Konstantinos; Naka, Katerina K.; Bourantas, Christos V.; Papamichael, Nikolaos D.; Kotsia, Anna; Tzimas, Thomas; Παππάς, Κωνσταντίνος; Katsouras, Christos S.; Michalis, Lampros K.

doi:10.1093/ajh/hps039

Cited by 32 publications

(26 citation statements)

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“…However, this association is likely diseasestage specific, as it was shown to be particularly strong in adult patients with angiographic evidence of changes in coronary arteries. 22 In our study, children with obesity and arterial hypertension presented with significantly higher values of PWV when compared to both controls and obese normotensive subjects. There were no statistically significant differences in PWV between obese normotensives and controls.…”

Section: Discussionsupporting

confidence: 49%

“…5 This parameter turned out to be correlated with the presence of obesity and coronary artery disease in adults. 22 In the case of children and adolescents, this association was more evident in patients with arterial hypertension than in obese individuals. 7,9 However, we did not find a similar relationship in our material; the only predictors of Aix@75, both in the whole group of children and in their subsets with/without overweight/obesity and arterial hypertension, were age, sex, HR, LV mass, LAD and cDia.…”

Section: Discussionmentioning

confidence: 99%

“…Other authors have documented associations between PWV and other markers of cardiovascular risk such as preperitoneal fat tissue thickness and waist/hip circumference. 8,22 However, we did not include these parameters in our analysis.…”

Section: Discussionmentioning

confidence: 99%

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Central aortic pressure, arterial stiffness and echocardiographic parameters of children with overweight/obesity and arterial hypertension

Wójtowicz¹,

Łempicka²,

Łuczyński³

et al. 2017

Adv Clin Exp Med

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Section: Discussionsupporting

confidence: 49%

Section: Discussionmentioning

confidence: 99%

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Central aortic pressure, arterial stiffness and echocardiographic parameters of children with overweight/obesity and arterial hypertension

Wójtowicz¹,

Łempicka²,

Łuczyński³

et al. 2017

Adv Clin Exp Med

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“…The main determinants of PWVcf were age and systolic blood pressure, 29 while AIx was associated with systolic blood pressure 30,31 and female gender, 32 and inversely with height 33 and central obesity probably due to decreased peripheral wave reflections. 15 PWVcr was mainly determined by diastolic blood pressure and gender as discussed above; these associations have not been previously reported. 34 In the current study, SI was found to be associated with peripheral arterial stiffness of the upper limb (PWVcr), while there was a trend for a significant association with AIx.…”

Section: Discussionmentioning

confidence: 79%

Clinical utility of digital volume pulse analysis in prediction of cardiovascular risk and the presence of angiographic coronary artery disease

Vakalis¹,

Bechlioulis²,

Naka³

et al. 2014

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Background: Stiffness Index (SI), assessed by finger photoplethysmography (digital volume pulse analysis), has been suggested as a simple and easy measure of arterial stiffness. However, its potential association with cardiovascular risk and coronary artery disease (CAD) has been little studied. The aims of the study were to investigate the relation of SI with classical risk factors and established arterial stiffness indices and its ability to predict cardiovascular risk and the presence of angiographic CAD. Methods: We enrolled 126 consecutive patients (mean age 61 years, 74% males) with suspected stable CAD undergoing diagnostic coronary angiography. Cardiovascular risk was assessed using Framingham risk score (FRS) and the European Heart score. Carotid-femoral (PWVcf) and carotid-radial (PWVcr) pulse wave velocity and augmentation index, using applanation tonometry, and SI using finger photoplethysmography, were measured in all patients. Results: SI was positively correlated with PWVcr (p Z 0.017) but not with PWVcf. Increased SI (R 2 0.19, p < 0.001) was independently associated with higher diastolic blood pressure and male gender. Increased SI and PWVcf were associated with higher FRS and Heart score (p < 0.05 for all), while only higher PWVcf was associated with the presence of angiographic CAD (p Z 0.007). Conclusions: SI, easily derived using finger photoplethysmography, was related to classical risk factors and peripheral arterial rather than aortic stiffness. SI and PWVcf were the only vascular indices associated with cardiovascular risk, but only PWVcf was related to the presence of

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“…Importantly, increased central vascular pulse wave velocity (PWV), a measure of arterial stiffening, is independently associated with CVD event risk (31). Accelerated arterial stiffening occurs in obesity whereby increased body mass index is associated with reduced arterial distensibility as early as adolescence (39,49,51) and is associated with angiographic evidence of coronary artery disease later in life (3). Thus, arterial stiffening is a significant contributor to and predictor of CVD development and progression.…”

Section: Associated With Endothelial Dysfunction Aberrant Extracellumentioning

confidence: 99%

Regional variation in arterial stiffening and dysfunction in Western diet-induced obesity

Bender

Castorena‐Gonzalez

Garro

et al. 2015

American Journal of Physiology-Heart and Circulatory Physiology

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, is an independent predictor of cardiovascular event risk. Recent evidence demonstrates that accelerated aortic stiffening occurs in obesity; however, little is known regarding stiffening of other disease-relevant arteries or whether regional variation in arterial stiffening occurs in this setting. We addressed this gap in knowledge by assessing femoral PWV in vivo in conjunction with ex vivo analyses of femoral and coronary structure and function in a mouse model of Western diet (WD; high-fat/high-sugar)-induced obesity and insulin resistance. WD feeding resulted in increased femoral PWV in vivo. Ex vivo analysis of femoral arteries revealed a leftward shift in the strain-stress relationship, increased modulus of elasticity, and decreased compliance indicative of increased stiffness following WD feeding. Confocal and multiphoton fluorescence microscopy revealed increased femoral stiffness involving decreased elastin/collagen ratio in conjunction with increased femoral transforming growth factor-␤ (TGF-␤) content in WD-fed mice. Further analysis of the femoral internal elastic lamina (IEL) revealed a significant reduction in the number and size of fenestrae with WD feeding. Coronary artery stiffness and structure was unchanged by WD feeding. Functionally, femoral, but not coronary, arteries exhibited endothelial dysfunction, whereas coronary arteries exhibited increased vasoconstrictor responsiveness not present in femoral arteries. Taken together, our data highlight important regional variations in the development of arterial stiffness and dysfunction associated with WD feeding. Furthermore, our results suggest TGF-␤ signaling and IEL fenestrae remodeling as potential contributors to femoral artery stiffening in obesity.

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Increased Aortic Pulse Wave Velocity Is Associated With the Presence of Angiographic Coronary Artery Disease in Overweight and Obese Patients

Abstract: Arterial stiffness indices were not consistently associated with obesity, opposite to what might have been expected. The association of increased CFPWV with the presence of angiographic CAD in patients with increased BMI or WC values warrants further research.

Cited by 32 publications

References 32 publications

Central aortic pressure, arterial stiffness and echocardiographic parameters of children with overweight/obesity and arterial hypertension

Central aortic pressure, arterial stiffness and echocardiographic parameters of children with overweight/obesity and arterial hypertension

Clinical utility of digital volume pulse analysis in prediction of cardiovascular risk and the presence of angiographic coronary artery disease

Regional variation in arterial stiffening and dysfunction in Western diet-induced obesity

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