Increased apoprotein B in very low density lipoproteins of patients with peripheral vascular disease.

Franceschini, Guido; Bondioli, A; Mantero, Marco; Sirtori, M; Tattoni, G; Biasi, G; Sirtori, C R

doi:10.1161/01.atv.2.1.74

Cited by 25 publications

(6 citation statements)

References 29 publications

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“…Among the "negative" risk factors for atherosclerosis, we found only apo A-ll a significant parameter. Our results were similar to those reported by Whayne et al 18 and Riesen et al 17 in patients with CVD, as well as to the results of Franceschini et al 9 in PVD patients in that we found no significant difference in HDL-C between PVD patients and controls.…”

Section: Discussionsupporting

confidence: 93%

“…Mertz 20 considered the atherosclerosis index (LDL-C/HDL-C) as the most prominent indicator for peripheral atherosclerosis. PVD patients and controls were well separated by VLDL-apo B/VLDL-C. 9 In this and other studies, however, there were no calculations on related subjects concerning specificity, sensitivity, or rate of misclassification using one or several parameters as discriminators. In this report we tried to find out which single parameter might best reflect peripheral atherosclerosis.…”

mentioning

confidence: 55%

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Risk factors for peripheral atherosclerosis. Retrospective evaluation by stepwise discriminant analysis.

Pilger¹,

Pristautz

Pfeiffer³

et al. 1983

Arteriosclerosis

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To evaluate the optimal discriminators for peripheral atherosclerosis, we studied retrospectively 49 male patients and 39 male controls between 40 and 60 years of age. In addition to hypertension, cigarette smoking, diabetes mellitus, and hyperuricemia, we determined the most common tipids, lipoproteins, and apolipoproteins. Highly significant differences of median values between patients and controls in decreasing order of magnitude were recorded for apo A-ll/apo B, apo A-l/apo B, apo B, total cholesterol, and LDL-cholesterol. A retrospective classification of patients and controls under optimal conditions with one variable (apo A-l/apo B) yielded an error rate of 25%. We found that apolipoproteins were better discriminators for peripheral atherosclerosis than were liplds or lipoprotein lipids. The application of a linear regression discriminant analysis including all 29 variables greatly decreased the rate of error and increased the sensitivity and specificity of the classification. From 2 29 possible models, we used an economic selection strategy to sort out those which either gave the best segregation or were considered the most practicable. The optimal model with 14 variables gave an error rate of less than 5% for the group studied. Suboptimal models yielded error rates between 13% and 18%. We conclude that a mathematical treatment of laboratory data which includes lipid parameters in addition to apolipoprotein values can improve the classification of peripheral vascular atherosclerosis. (Arteriosclerosis 3:57-63, January/February 1983)

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Section: Discussionsupporting

confidence: 93%

mentioning

confidence: 55%

Risk factors for peripheral atherosclerosis. Retrospective evaluation by stepwise discriminant analysis.

Pilger¹,

Pristautz

Pfeiffer³

et al. 1983

Arteriosclerosis

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“…Also among the PVD patients, significantly higher blood levels of Apo B were measured, with total cholesterol concentrations that tended to be lower,.. Ns, than for the controls. This result is similar to findings of other authors (19,36,56) for PVD patients not selected according to their clinical stages. The Apo B increase could also suggest a change in the lipoprotein composition of LDL-C and VLDL-, with the appearance of Apo B-icher lipoproteins and, probably, more atherogenesis (36).…”

Section: No Significant Difference Between Pvd Patientssupporting

confidence: 92%

“…The data concerning other lipidic parameters such as LDL-C and Apo still seem contradictory (1,(19)(20)(21)36). However, the discrepancies found in literature might be due to a failure to apply strict selection ' criteria to the patients enrolled in the various dinical studies concerning this disease.…”

mentioning

confidence: 99%

Arterial Damage, Triglycerides, Apolipoprotein, and Lp-(a) Values in PVD Patients

Catalano

Perilli

Carzaniga

et al. 1997

Clin Appl Thromb Hemost

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The aim of the study was to provide a detailed apolipoproteic profile in stage II peripheral vascular disease (PVD) patients and to ascertain whether lower ankle/ arm pressure index (API) values were associated with a worse profile.Apolipoproteins of 83 stage II PVD patients (average age 64.7 & p l u s m n ; 9.3 years) were selected and compared with those of a group of 44 normal control subjects, similar in terms of age, sex, and smoking and eating habits. Neither PVD patients nor controls had ever received lipidlowering agents or defined dietary treatment. A diagnosis of PVD was confirmed by an API of <0.85. Arteriopathic patients were also split into two groups, depending on their API values, similar in terms of age, sex and smoking habits: API values of one group (n = 38) were ≥0.6, those of the other group (n = 45) were <0.6. The following biohumoral parameters were considered: fasting glycemia, total cholesterol, triglycerides (TGs)

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“…According to studies of Franceschini et al (6), increased concentrations of apolipoprotein B in VLDL are associated with peripheral vascular disease. Therefore, the determination of VLDL apolipoprotein B may be of special clinical and epidemiological significance.…”

Section: Introductionmentioning

confidence: 99%

VLDL Apolipoprotein B Determination in Blood Serum Following Precipitation of LDL with Polyvinylsulphate

Schriewer¹,

Nolte²,

Assmann³

1985

Clinical Chemistry and Laboratory Medicine

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A method is described for the determination of VLDL apolipoprotein B by radial immunodiffusion (RID) in serum supernatants following precipitation of LDL with polyvinylsulphate. The rneasurement of VLDL apolipoprotein B is based on the incubation of the polyvinylsulphate supernatant with triglyceride lipase (330 kU/1 end concentration) for 12 -24 hours at 37 °C. A good measure of agreement was found for the corresponding VLDL apolipoprotein B values measured by RID in % the polyvinylsulphate supernatants (y) and VLDL apolipoprotein B values calculated äs tetramethylurea-insohible protein in the d < 1.006 kg/l serum fraction (x) (r = 0.88, y = 0.96x + 0.004, n = 54). Within the tested ränge of 1.2 mmol/1 to 6.7 mmol/1 triglycerides, the concentration of apolipoprotein B measured in the polyvinylsulphate supernatant showed a linear relationship. Correlation analysis of VLDL apolipoprotein B values and serum triglycerides \ and VLDL cholestefol, respectively, showed a good correlation (r = 0.77 and r = 0.75, respectively, n = ( 54). In the determination of VLDL apolipoprotein B measured in polyvinylsulphate supernatant, a Variation coefficient of 4.3% (x = 10.1 mmol/1, n = 20) was found in relation to the precision in the series, and a [ Variation coefficient of 11.4% (x = 5.3 mmol/1, n = 15) in relation to day to day precision. VLDL Apolipoprotein B Bestimmung im Blutserum nach Präzipitation von LDL mit PolyvinylsulfatZusammenfassung: Es wird eine Methode zur Bestimmung von VLDL Apolipoprotein B mittels radialer Immundiffusion (RID) im Fällungsüberstand nach Vorheriger Präzipitation der LDL mit Polyvinylsulfat i beschrieben. Die Richtigkeit der Messung von VLDL Apolipoprotein B gründet sich auf die Inkubation der j Poly vinylsülfat-Fällungsüberstände mit Triglyceridlipase (330 kU/1 Endkonzentration) für 12-24 Stunden bei | 37 °C. Es wurde eine gute Übereinstimmung der VLDL Apolipoprotein B-Wertepaare gefunden, die mittels | RID im Polyvinylsulfat-Überstand (y) gemessen und als Tetramethylharnstoff unlösliches Protein in der j d < 1,006 kg/l Serumfraktion (x) ermittelt wurden (r = 0,88, y = 0,96x + 0,004, n = 54). Innerhalb des untersuchten Bereichs von 1,2 miiiol/1 bis 6,7 mmol/1 Triglyceriden waren die VLDL Apolipoprotein B-Werte im Fällungsüberstand linear. Die Kprrelationsanalyse der im Polyvinylsialfat-Fällungsüberstand gemessenen VLDL Apolipoprotein B-Werte und der Triglycerid-bzw. der VLDL Cholesterinwerte im Serum ergab eine gute Korrelation der jeweiligen Wertepaare (r = 0,77, bzw. r = 0,75; n = 54). Der Variationskoeffizient der VLDL Apolipoprotein B-Bestimmung' nach Polyvinylsulfat-Fällung hinsichtlich der Präzision in der Serie ibetrug 4,3% (x = 10,1 mmöl/1, n = 20) und hinsichtlich der Präzision von Tag zu Tag 11,4% (x = 5,3 l mmol/1, n = 15).

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Increased apoprotein B in very low density lipoproteins of patients with peripheral vascular disease.

Cited by 25 publications

References 29 publications

Risk factors for peripheral atherosclerosis. Retrospective evaluation by stepwise discriminant analysis.

Risk factors for peripheral atherosclerosis. Retrospective evaluation by stepwise discriminant analysis.

Arterial Damage, Triglycerides, Apolipoprotein, and Lp-(a) Values in PVD Patients

VLDL Apolipoprotein B Determination in Blood Serum Following Precipitation of LDL with Polyvinylsulphate

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