Increased apoptosis and cysteinyl aspartate specific protease-3 gene expression in human intracranial aneurysm

Guo, Fuyou; Li, Zhihua; Song, Laijun; Han, Tian-wang; Feng, Qiaoxian; Guo, Yuda; Xu, Jianguo; He, Min; You, Chao

doi:10.1016/j.jocn.2005.11.018

Cited by 55 publications

(42 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Caspase‐3 is an autocatalytic enzyme that plays a key role in apoptosis process. The reduced intracranial aneurysm has been associated with increased caspase‐3 expression (Guo et al., 2007), and our data also agreed on these findings.…”

Section: Discussionsupporting

confidence: 92%

A study on effect of curcumin on anticerebral aneurysm in the male albino rats

Miao

Wang

et al. 2017

Brain and Behavior

View full text Add to dashboard Cite

IntroductionThis study investigated the curcumin effect on the cerebral aneurysm. Apoptosis is known to play a fundamental role in the pathogenesis of a cerebral aneurysm. Therefore, we investigated the effect of curcumin on apoptosis of smooth muscle cells of a cerebral aneurysm‐induced male albino rats.MethodsIn this study, the cerebral aneurysm has been induced in the male albino rats by the CaCl2 administration. After cerebral aneurysm induction, smooth muscle cells were isolated. Cells were treated with curcumin (25 & 50 mg/kg bwt) for 48 hr.ResultsCurcumin reduced altered mitochondrial morphology significantly, evidenced through fluorescence and confocal study. Curcumin treatment reduced the expression of p53, caspase‐3, and bax/bxl‐2 ratio significantly. Curcumin treatment also reversed the cellular architecture of smooth muscle cell wall significantly. Fluorescence and the confocal study confirmed the reduction in apoptosis in a cerebral aneurysm‐induced smooth muscle cells of male albino rats.ConclusionTaking all these data together, it may suggest that the curcumin could significantly reduce the CaCl2‐induced cerebral aneurysm through the inhibition of cell apoptosis in the cells.

show abstract

Section: Discussionsupporting

confidence: 92%

A study on effect of curcumin on anticerebral aneurysm in the male albino rats

Miao

Wang

et al. 2017

Brain and Behavior

View full text Add to dashboard Cite

show abstract

“…25 Apoptosis of medial smooth muscle cells has been observed in human IAs. 26 Endothelial apoptosis may also occur during cerebral vasospasm after SAH. 27 Furthermore, the extrinsic apoptotic signaling pathway that involves TNF-␣ and the downstream signaling molecule FADD seem to initiate vessel weakening and remodeling in human IAs.…”

Section: Discussionmentioning

confidence: 99%

Genomics of Human Intracranial Aneurysm Wall

Shi

Awad

Jafari

et al. 2009

Stroke

108

View full text Add to dashboard Cite

Background and Purpose-The pathogenesis of intracranial aneurysms (IAs) remains elusive. Most studies have focused on individual genes, or a few interrelated genes or products, at a time in human IA. However, a broad view of pathologic mechanisms has not been investigated by identifying pathogenic genes and their interaction in networks. Our study aimed to analyze global gene expression patterns in the IA wall. Methods-To our knowledge, our group was the first to perform Illumina microarray analysis on human IA via comparison of aneurysm wall and superficial temporal artery tissues from 6 consecutive patients. We adopted stringent statistical criteria to the individual genes; genes with a false discovery rate Ͻ0.01 and Ͼ2-fold change were selected as differentially expressed. To identify the overrepresented biologic pathways with the differentially expressed genes, we performed hypergeometric testing of the genes selected by relaxed criteria of PϽ0.01 and fold change Ͼ1.5. Results-There are 326 distinct differentially expressed genes between IA and superficial temporal artery tissues (Ͼ2-fold change) with a false discovery rate Ͻ0.01. Analysis of the Kyoto Encyclopedia of Genes and Genomes pathways revealed the most impacted functional pathways: focal adhesion, extracellular matrix receptor interaction, and cell communication. Analysis of the Gene Ontology also supported the involvement of another 2 potentially important pathways: inflammatory response and apoptosis. Conclusions-The differentially expressed genes in the aneurysm wall may shed light on aneurysm pathobiology and provide novel targets for therapeutic intervention. These data will help generate hypotheses for future studies. (Stroke.

show abstract

“…Activation of cysteinedependent aspartate-directed proteases (caspases), the effector enzymes of apoptosis, is an alternative marker for apoptosis. Guo et al [23] showed in a Chinese series of 15 ruptured sIA that caspase activity is found in the sIA wall in addition to Tunel positivity. In addition, Pentimalli et al [61] and Tulamo et al [85] showed apoptotic cells in the sIA walls with electron microscopy.…”

Section: Why Do Sias Rupture? Observations From Gene Expression Studiesmentioning

confidence: 99%

Saccular intracranial aneurysm: pathology and mechanisms

Tulamo²,

et al. 2012

View full text Add to dashboard Cite

Saccular intracranial aneurysms (sIA) are pouch-like pathological dilatations of intracranial arteries that develop when the cerebral artery wall becomes too weak to resist hemodynamic pressure and distends. Some sIAs remain stable over time, but in others mural cells die, the matrix degenerates, and eventually the wall ruptures, causing life-threatening hemorrhage. The wall of unruptured sIAs is characterized by myointimal hyperplasia and organizing thrombus, whereas that of ruptured sIAs is characterized by a decellularized, degenerated matrix and a poorly organized luminal thrombus. Cell-mediated and humoral inflammatory reaction is seen in both, but inflammation is clearly associated with degenerated and ruptured walls. Inflammation, however, seems to be a reaction to the ongoing degenerative processes, rather than the cause. Current data suggest that the loss of mural cells and wall degeneration are related to impaired endothelial function and high oxidative stress, caused in part by luminal thrombosis. The aberrant flow conditions caused by sIA geometry are the likely cause of the endothelial dysfunction, which results in accumulation of cytotoxic and pro-inflammatory substances into the sIA wall, as well as thrombus formation. This may start the processes that eventually can lead to the decellularized and degenerated sIA wall that is prone to rupture.

show abstract

Increased apoptosis and cysteinyl aspartate specific protease-3 gene expression in human intracranial aneurysm

Cited by 55 publications

References 24 publications

A study on effect of curcumin on anticerebral aneurysm in the male albino rats

A study on effect of curcumin on anticerebral aneurysm in the male albino rats

Genomics of Human Intracranial Aneurysm Wall

Saccular intracranial aneurysm: pathology and mechanisms

Contact Info

Product

Resources

About