Increased arterial stiffness in nonalcoholic fatty liver disease: the Cardio-GOOSE study

Salvi, Paolo; Ruffini, R.; Agnoletti, Davide; Magnani, Elena; Pagliarani, Gabriele; Comandini, G.; Praticò, Antonino; Borghi, Claudio; Bénétos, Athanase; Pazzi, P.

doi:10.1097/hjh.0b013e32833a7de6

Cited by 108 publications

(78 citation statements)

References 48 publications

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“…28,29 Therefore, whether the increased cardiovascular risk in NAFLD patients is simply an epiphenomenon conferred by metabolic syndrome is still in debate. Our study, along with some others, 6,7 demonstrated that the strong correlation between atherosclerosis and NAFLD was independent of insulin resistance and metabolic syndrome. Meanwhile, subjects with both NAFLD and metabolic syndrome had remarkably higher levels of CIMT and ba-PWV compared with those with either of these diseases, which imply that the effect on atherosclerosis of NAFLD or metabolic syndrome might not fully overlap.…”

Section: Discussionsupporting

confidence: 83%

“…[5][6][7][8][9][10][11][12][13] In some relatively small samples from the community population, ultrasonographically diagnosed NAFLD has been found to be independently associated with carotid atherosclerosis and arterial stiffness. 6,7 Biopsy-proven NAFLD patients had remarkably greater carotid intimamedia thickness (CIMT) compared with that of age-, sex-, and body mass index (BMI)-matched healthy subjects in a case-control study. 8 Nevertheless, in another study including 101 patients with type 2 diabetes mellitus, NAFLD diagnosed by 1H-magnetic resonance spectroscopy is not associated with CIMT.…”

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confidence: 99%

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Nonalcoholic Fatty Liver Disease Is Associated With Atherosclerosis in Middle-Aged and Elderly Chinese

Huang

et al. 2012

ATVB

108

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Objective-To evaluate the associations between nonalcoholic fatty liver disease (NAFLD) and atherosclerosis. Methods and Results-A total of 8632 participants aged ≥40 years from Jiading district, Shanghai, were included in the present study. The presence of NAFLD was evaluated by ultrasonography. Carotid intima-media thickness (CIMT) and brachial-ankle pulse wave velocity (ba-PWV) were measured in each participant. The prevalence of NAFLD was 30.0% in the total population, with 30.3% in men and 29.9% in women, respectively. Subjects with NAFLD had remarkably higher CIMT and ba-PWV compared with those without NAFLD (0.594±0.105 mm versus 0.578±0.109 mm, P<0.0001; 1665±424 cm/s versus 1558±430 cm/s, P<0.0001). Subjects with both NAFLD and metabolic syndrome had significantly higher CIMT and ba-PWV compared with those with neither or either of these 2 diseases after adjustment for age and sex (all P<0.05). Logistic regressions also revealed that NAFLD conferred 35% and 30% increased odds ratios of elevated CIMT and ba-PWV, independent of conventional risk factors and the presence of metabolic syndrome. Key Words: atherosclerosis ◼ brachial-ankle pulse wave velocity ◼ carotid intima-media thickness ◼ metabolic syndrome ◼ nonalcoholic fatty liver disease Conclusion-NAFLD

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Section: Discussionsupporting

confidence: 83%

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confidence: 99%

Nonalcoholic Fatty Liver Disease Is Associated With Atherosclerosis in Middle-Aged and Elderly Chinese

Huang

et al. 2012

ATVB

108

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“…It affects 20-35% of the general population in developed countries and its prevalence reaches 70-90% in subjects with obesity, MetS or T2DM [52]. NAFLD is considered the hepatic manifestation of MetS, since it is closely related to other clinical features of MetS [53,54]. Interestingly, AS appears to be independently associated with NAFLD [53,54].…”

Section: As In Mets-associated Nafldmentioning

confidence: 99%

“…NAFLD is considered the hepatic manifestation of MetS, since it is closely related to other clinical features of MetS [53,54]. Interestingly, AS appears to be independently associated with NAFLD [53,54]. Moreover, the results of a large study (n=4,467) suggested that not only the presence but also the severity of NAFLD are associated with AS in non-hypertensive, nondiabetic subjects with or without MetS [55].…”

Section: As In Mets-associated Nafldmentioning

confidence: 99%

Treating Arterial Stiffness Associated with Features of Metabolic Syndrome Not Included in its Diagnostic Criteria: Cutting Off the Heads of Lernaean Hydra, Keeper of the Underworld

Athyros¹,

Ferlita²,

Τζιόμαλος³

et al. 2013

TOHYPERJ

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Abstract:The clustering of cardio-metabolic risk factors, regardless if this is called metabolic syndrome (MetS) or not, substantially increases the risk of cardiovascular disease (CVD) and all-cause mortality. One of the possible mechanisms of the rise in CVD incidence is the increase in arterial stiffness (AS), which is a significant and independent CVD risk factor. Hypertension has long been connected to AS. Besides MetS components (obesity, dyslipidaemia, hypertension, dysglycaemia), MetS-associated disease states, not included in the MetS diagnostic criteria (renal dysfunction, hyperuricaemia, non alcoholic fatty liver disease, obstructive sleep apnea, polycystic ovary syndrome and hypercoaglutability) have been implicated in the increase of CVD risk through the increase of AS, among other mechanisms. Treatment options for AS induced by these non-diagnostic features of MetS are discussed. The impact of lifestyle changes is analyzed. Among pharmacological interventions, statin treatment seams to hold a pivotal role. Furthermore, we discuss specific measures for each disease state separately.

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“…9 Several factors, such as obesity, diabetes, metabolic syndrome, hypertension and dyslipidemia, are proven to be associated with arterial stiffness. 10 Although there is an insignificant association between NAFLD and arterial stiffness in hypertensive patients without additional cardiovascular risk factors, 11 studies have shown that NAFLD is positively related to arterial stiffness in general population [12][13][14] and adolescents. 15 Furthermore, a positive association of NAFLD with arterial stiffness was also found in non-hypertensive and nondiabetic subjects.…”

Section: Introductionmentioning

confidence: 99%

Non-alcoholic fatty liver disease associated with increased arterial stiffness in subjects with normal glucose tolerance, but not pre-diabetes and diabetes

Chou

Yang

et al. 2015

Diabetes and Vascular Disease Research

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Aim: To evaluate the association between non-alcoholic fatty liver disease and arterial stiffness in adults with normal glucose tolerance, pre-diabetes and newly diagnosed diabetes after excluding known diabetes. Methods: A total of 4860 subjects were divided into normal glucose tolerance, pre-diabetes and newly diagnosed diabetes groups according to the American Diabetes Association 2011 diagnostic criteria. The severity of non-alcoholic fatty liver disease was divided into mild and moderate to severe. Increased arterial stiffness was defined as brachial-ankle pulse wave velocity (baPWV) ⩾ 1400 cm/s. Results: There was a significant difference in the prevalence of mild and moderate to severe non-alcoholic fatty liver disease between subjects with and without increased arterial stiffness. Mild (odds ratio (OR) = 2.02, 95% confidence interval (CI) = 1.43-2.84) and moderate to severe (OR = 2.15, 95% CI = 1.33-3.46) non-alcoholic fatty liver disease were independently associated with increased arterial stiffness in the normal glucose tolerance group. In the pre-diabetes and diabetes groups, neither mild nor moderate to severe non-alcoholic fatty liver disease was associated with increased arterial stiffness. Conclusion:The effect of non-alcoholic fatty liver disease on arterial stiffness is apparent in subjects with normal glucose tolerance, but not in diabetes and pre-diabetes.

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Increased arterial stiffness in nonalcoholic fatty liver disease: the Cardio-GOOSE study

Abstract: This study has shown a possible independent role of NAFLD in determining arterial stiffness.

Cited by 108 publications

References 48 publications

Nonalcoholic Fatty Liver Disease Is Associated With Atherosclerosis in Middle-Aged and Elderly Chinese

Nonalcoholic Fatty Liver Disease Is Associated With Atherosclerosis in Middle-Aged and Elderly Chinese

Treating Arterial Stiffness Associated with Features of Metabolic Syndrome Not Included in its Diagnostic Criteria: Cutting Off the Heads of Lernaean Hydra, Keeper of the Underworld

Non-alcoholic fatty liver disease associated with increased arterial stiffness in subjects with normal glucose tolerance, but not pre-diabetes and diabetes

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