Increased bladder activity is associated with elevated oxidative stress markers and proinflammatory cytokines in a rat model of atherosclerosis‐induced chronic bladder ischemia

Nomiya, Masanori; Sagawa, Koji; Yazaki, Junji; Takahashi, Norio; Kushida, Nobuhiro; Haga, Nobuhiro; Aikawa, Kohsuke; Matsui, Takahiro; Oka, Michiko; Fukui, Tomijiro; Andersson, Karl‐Erik; Yamaguchi, Osamu

doi:10.1002/nau.21191

Cited by 90 publications

(114 citation statements)

References 31 publications

Supporting

Mentioning

100

Contrasting

Unclassified

Order By: Relevance

“…Applying the combination of a high-cholesterol diet with balloon injury to the iliac artery in rats confirmed many findings from the rabbit model (Nomiya et al 2012a(Nomiya et al , 2012b. In those studies, atherosclerosis was reported not only for the iliac arteries abut also for bladder microvessels.…”

Section: Effects Of Chronic Hypoperfusion Of the Bladdersupporting

confidence: 64%

Are blood vessels a target to treat lower urinary tract dysfunction?

Michel

Chess-Williams

Hegde

2015

Naunyn-Schmiedeberg's Arch Pharmacol

View full text Add to dashboard Cite

Bladder dysfunction is common in the general population (Stewart et al. 2010) and even more so among patients seeing a physician for any reason (Goepel et al. 2002). It often manifests as lower urinary tract symptoms (LUTS), a term originally coined to describe voiding and storage symptoms in men with benign prostatic hyperplasia (BPH) but now more universally used to describe any type of voiding and storage symptoms in both sexes. Studies into possible causes of urinary bladder dysfunction have long focused on detrusor smooth muscle cells (Turner and Brading 1999). More recently, it became clear that several other types of cells and organs contribute to regulating detrusor smooth muscle function. These include the urothelium (Andersson and McCloskey 2014; Michel 2015), afferent nerves (Michel and Igawa 2015; Yoshimura et al. 2014b), and the central and autonomic nervous systems (Fowler and Griffiths 2010; Yoshimura et al. 2014a). Alterations in any of these may at least partly be responsible for detrusor dysfunction and, accordingly, be potential targets for the treatment of bladder dysfunction. As highlighted by an article in this issue of Naunyn-Schmiedeberg's Archives of Pharmacology (Bayrak et al. 2015), there is an additional suspect, the bladder vasculature. This article will discuss the currently available experimental and clinical evidence for a role of the vasculature in causing bladder dysfunction, and how existing and emerging treatments may modulate bladder function by acting on blood vessels. Due to a similarity in concept, data on prostate perfusion will also be discussed to some extent.

show abstract

Section: Effects Of Chronic Hypoperfusion Of the Bladdersupporting

confidence: 64%

Are blood vessels a target to treat lower urinary tract dysfunction?

Michel

Chess-Williams

Hegde

2015

Naunyn-Schmiedeberg's Arch Pharmacol

View full text Add to dashboard Cite

show abstract

“…Thus, the increase of the locomotor activity in the pelvic venous congestion rats that was observed in our current study suggests that naftopidil may have both a capillary stabilizing action, and inhibit the extravascular leakage of stimulatory substances that act on the bladder. In the atherosclerosis-induced chronic bladder ischemia rat model, changes in the urinary frequency were shown to be associated with an increase of oxidative stress markers in the urine or bladder tissue (17,19). Furthermore, atherosclerosis-induced chronic ischemic bladder also decreased constitutive nitric oxide synthase (NOS) (20).…”

Section: Discussionmentioning

confidence: 99%

<b>Naftopidil improves locomotor activity and urinary frequency in rats with pelvic venous </b><b>congestion </b>

Sugaya¹,

Nishijima²,

Kadekawa³

et al. 2016

Biomed. Res.

View full text Add to dashboard Cite

The α1D/A receptor antagonist, naftopidil, inhibits micturition reflex by acting on various different sites. We examined the effects of naftopidil on bladder activity and changes in the induced urinary frequency using female rats with pelvic venous congestion (PC). Twenty-four female rats were divided into sham, PC, and PC/naftopidil groups. After anesthetizing rats in the PC and PC/naftopidil groups, the bilateral common iliac veins and uterine veins were ligated. Rats in the sham and PC groups were fed a standard diet, while rats in the PC/naftopidil group were fed diets containing 0.04% naftopidil. After 4 weeks of treatment, locomotor activity, urinary nitric oxide metabolites (NOx), continuous cystometry, and plasma monoamine measurements were performed. PC rats exhibited a decrease of locomotor activity, a shorter interval between bladder contractions on continuous cystometry, and decreased urinary NOx and plasma serotonin levels than the sham rats. The PC/naftopidil rats exhibited an increase of locomotor activity, a longer interval between bladder contractions, and increased urinary NOx and plasma serotonin levels. Therefore, naftopidil might improve bladder dysfunction induced by pelvic venous congestion due to several actions in the central nervous system and bladder tissue, as well as acting as an α1 blocker to cause pelvic venous dilation.Unilateral or bilateral ovarian vein incompetence can cause pelvic congestion syndrome, which induces chronic pain, irritable bladder, dysfunction of the pelvic organs, or vulval varices and varicose veins in the lower limbs (1, 5, 7). Our previous study demonstrated that chronic prostatitis and stress urinary incontinence were related to the existence of vena cava reflux caused by tricuspid regurgitation (28). When we examined a female case with pelvic congestion syndrome using external iliac venography, we found that pelvic venous congestion occurred with tricuspid regurgitation and without pelvic venous valves (25). Our previous studies have also demonstrated that ligation of the bilateral common iliac veins in male rats or ligation of the bilateral common iliac veins and uterine veins in female rats induced changes in the urinary frequency and low locomotor activity (30). As compared to the intact rats, these surgically altered rats exhibited a bladder blood flow decrease that was about 80% of the flow in the intact bladder. Therefore, pelvic venous congestion may be one of the causes of pelvic ischemia, and might be related to several lower urinary tract symptoms/diseases. When examining hypertension, the relevance of lower urinary tract symptoms and their association with hypertension need to be taken into consideration. Spontaneously hypertensive rats have been shown to have a significantly lower bladder capacity and voiding volume (24), and these rats also exhibit

show abstract

“…Yoshida et al reported myocardial infarction-prone Watanabe Heritable Hyperlipidemic rabbits, an animal model for human familial 8 hypercholesterolemia and atherosclerosis, showed detrusor overactivity with decreased detrusor contraction 8 . Another study using the rat model of atherosclerosis-induced chronic bladder ischemia showed that reduction in BBF was associated with detrusor overactivity and urinary frequency 9 , and that the levels of oxidative stress markers and proinflammatory cytokines were increased in rats with chronic bladder ischemia 10 . In a clinical study using …”

Section: Discussionmentioning

confidence: 99%

The impact of abdominal aortic calcification and visceral fat obesity on lower urinary tract symptoms in patients with benign prostatic hyperplasia

Motoya

Matsumoto

Yamaguchi³

et al. 2014

Int Urol Nephrol

View full text Add to dashboard Cite

Increased bladder activity is associated with elevated oxidative stress markers and proinflammatory cytokines in a rat model of atherosclerosis‐induced chronic bladder ischemia

Abstract: Oxidative stress and inflammation may be key factors in the development of bladder overactivity in atherosclerosis-induced chronic bladder ischemia.

Cited by 90 publications

References 31 publications

Are blood vessels a target to treat lower urinary tract dysfunction?

Are blood vessels a target to treat lower urinary tract dysfunction?

<b>Naftopidil improves locomotor activity and urinary frequency in rats with pelvic venous </b><b>congestion </b>

The impact of abdominal aortic calcification and visceral fat obesity on lower urinary tract symptoms in patients with benign prostatic hyperplasia

Contact Info

Product

Resources

About