2023
DOI: 10.1038/s41598-023-43675-w
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Increased blood immune regulatory cells in severe COVID-19 with autoantibodies to type I interferons

Fatemeh Saheb Sharif-Askari,
Narjes Saheb Sharif-Askari,
Shirin Hafezi
et al.

Abstract: The hallmark of severe COVID-19 is an uncontrolled inflammatory response, resulting from poorly understood immunological dysfunction. While regulatory T (Treg) and B (Breg) cells, as the main elements of immune homeostasis, contribute to the control of hyperinflammation during COVID-19 infection, we hypothesized change in their levels in relation to disease severity and the presence of autoantibodies (auto-Abs) to type I IFNs. Cytometric analysis of blood of 62 COVID-19 patients with different severities revea… Show more

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Cited by 8 publications
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