2022
DOI: 10.1136/bmjopen-2021-059108
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Increased blood pressure variability during general anaesthesia is associated with worse outcomes after mechanical thrombectomy: a prospective observational cohort study

Abstract: ObjectivesOptimal periprocedural blood pressure (BP) management during mechanical thrombectomy (MT) for acute ischaemic stroke is still controversial. The aim of this study was to investigate the association between intraprocedural BP variability (BPV) and outcomes in patients with large vessel occlusion (LVO) following MT with general anaesthesia.DesignA prospective observational cohort study.SettingThis study was conducted in a single tertiary hospital of Hangzhou in Zhejiang province.ParticipantsA total of … Show more

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Cited by 3 publications
(1 citation statement)
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“…However, according to an individual patient data meta-analysis that included 2460 patient data derived from five observational studies, systolic BPV within the first 24 h post-EVT, as expressed by the highest tertile of both standard deviation and coefficient of variation, was associated with higher mortality and disability at 3 months, independently of the mean systolic BP levels [86]. These results were further confirmed by several other cohort studies during the last few years (Table 2) [87][88][89][90], highlighting that the association of BPV with adverse clinical outcomes may even be intensified among patients receiving general anesthesia [91] or additional rescue treatment with balloon angioplasty or stenting [92]. One study-level meta-analysis that included 11 studies comprising more than 3500 patients, confirmed that higher systolic BPV was associated with lower odds of achieving good functional outcomes at 3 months [93].…”
Section: Blood Pressure Variability Among Patients With Acute Ischaem...supporting
confidence: 57%
“…However, according to an individual patient data meta-analysis that included 2460 patient data derived from five observational studies, systolic BPV within the first 24 h post-EVT, as expressed by the highest tertile of both standard deviation and coefficient of variation, was associated with higher mortality and disability at 3 months, independently of the mean systolic BP levels [86]. These results were further confirmed by several other cohort studies during the last few years (Table 2) [87][88][89][90], highlighting that the association of BPV with adverse clinical outcomes may even be intensified among patients receiving general anesthesia [91] or additional rescue treatment with balloon angioplasty or stenting [92]. One study-level meta-analysis that included 11 studies comprising more than 3500 patients, confirmed that higher systolic BPV was associated with lower odds of achieving good functional outcomes at 3 months [93].…”
Section: Blood Pressure Variability Among Patients With Acute Ischaem...supporting
confidence: 57%