Increased Body Mass Index Is Associated with Earlier Time to Loss of Response to Infliximab in Patients with Inflammatory Bowel Disease

Harper, Jason; Sinanan, Mika; Zisman, Timothy L.

doi:10.1097/mib.0b013e31829cf401

Cited by 135 publications

(106 citation statements)

References 26 publications

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“…In the present sample, the results of the complete anthropometric evaluation draw one's attention to a "nutritional paradox", with high frequencies of both -muscle depletion, as demonstrated by AMC, as well as excess weight and abdominal obesity -. This finding is in agreement with the scientific literature regarding the occurrence of a nutritional transition among patients with IBD (14,27) . However, the fact that obesity has been increasing in this population may not mean that protein depletion is diminished over the time in patients with IBD.…”

Section: Discussionsupporting

confidence: 83%

“…In the comparison between groups, the patients with UC had higher mean BMI, AC, AMC, TSF and WC, which is in agreement with data reported in the literature (13,14,27,33) . These findings demonstrate the preservation of nutritional status among such patients in comparison to those with CD.…”

Section: Discussionsupporting

confidence: 82%

“…However, evidence suggests the occurrence of a nutritional transition process in such individuals. Obesity, including severe/morbid obesity, has emerged as a growing problem in this population, bringing with it an increased risk for metabolic diseases, especially those of a cardiovascular origin (3,14,41) . While the mechanism for this event is not yet fully clarified, factors such as chronic inflammation, the type of intestinal microbiota, metabolic disorders secondary to the use of medication for controlling IBD, disease remission and physical activity may be .…”

Section: Introductionmentioning

confidence: 99%

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Excessive Weight – Muscle Depletion Paradox and Cardiovascular Risk Factors in Outpatients With Inflammatory Bowel Disease

Andrade

Maio

Dourado

et al. 2015

Arq. Gastroenterol.

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-Background -Evidence suggests a nutritional transition process in patients with inflammatory bowel disease. Obesity, which was once an uncommon occurrence in such patients, has grown in this population at the same prevalence rate as that found in the general population, bringing with it an increased risk of cardiovascular disease. Objective -The aim of the present study was to determine the nutritional status and occurrence of cardiovascular risk factors in patients with inflammatory bowel disease. Methods -A case-series cross-sectional study was conducted involving male and female adult outpatients with inflammatory bowel disease. Data were collected on demographic, socioeconomic, clinical and anthropometric variables as well as the following cardiovascular risk factors: sedentary lifestyle, excess weight, abdominal obesity, medications in use, comorbidities, alcohol intake and smoking habits. The significance level for all statistical tests was set to 5% (P < 0.05). Results -The sample comprised 80 patients with inflammatory bowel disease, 56 of whom (70.0%) had ulcerative colitis and 24 of whom (30.0%) had Crohn's disease. Mean age was 40.3±11 years and the female genre accounted for 66.2% of the sample. High frequencies of excess weight (48.8%) and abdominal obesity (52.5%) were identified based on the body mass index and waist circumference, respectively, in both groups, especially among those with ulcerative colitis. Muscle depletion was found in 52.5% of the sample based on arm muscle circumference, with greater depletion among patients with Crohn's disease (P=0.008). The most frequent risk factors for cardiovascular disease were a sedentary lifestyle (83.8%), abdominal obesity (52.5%) and excess weight (48.8%). Conclusion -The results of the complete anthropometric evaluation draw one's attention to a nutritional paradox, with high frequencies of both -muscle depletion, as well as excess weight and abdominal obesity. HEADINGS -Inflammatory bowel disease. Overweight. Malnutrition. Risk factors. Cardiovascular disease.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

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Excessive Weight – Muscle Depletion Paradox and Cardiovascular Risk Factors in Outpatients With Inflammatory Bowel Disease

Andrade

Maio

Dourado

et al. 2015

Arq. Gastroenterol.

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“…Obesity represents a real challenge in IBD patients. Recent data demonstrated that overweight patients could have earlier secondary loss of response rates during biological therapy (5) . Moreover, there is solid evidence that demonstrates higher rates of postoperative complications in CD patients with higher BMI as compared to eutrophic subjects (3) .…”

Section: Dear Sirmentioning

confidence: 99%

Obesity and Crohn’s disease: what comes first, the egg or the chicken?

Kotze

2017

Arq. Gastroenterol.

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“…The rise of obesity is especially concerning in patients with IBD as it a known risk factor for colorectal cancer (CRC) [71], and can affect the efficacy of medical treatment [72]. We have previously reviewed the role of the gut microbiota in obesity [73].…”

Section: The Changing Phenotype Of Ibdmentioning

confidence: 99%

The microbiota in inflammatory bowel disease

2015

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This review explores our current understanding of the complex interaction between environmental risk factors, genetic traits and the development of inflammatory bowel disease. The primacy of environmental risk factors is illustrated by the rapid increase in the incidence of the disease worldwide. We discuss how the gut microbiota is the proximate environmental risk factor for subsequent development of inflammatory bowel disease. The evolving fields of virome and mycobiome studies will further our understanding of the full potential of the gut microbiota in disease pathogenesis. Manipulating the gut microbiota is a promising therapeutic avenue.

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Increased Body Mass Index Is Associated with Earlier Time to Loss of Response to Infliximab in Patients with Inflammatory Bowel Disease

Abstract: Increased body weight is associated with an earlier time to loss of response to IFX in Crohn's disease and ulcerative colitis, a novel finding given that IFX is the only antitumor necrosis factor agent whose dosing reflects increased body weight.

Cited by 135 publications

References 26 publications

Excessive Weight – Muscle Depletion Paradox and Cardiovascular Risk Factors in Outpatients With Inflammatory Bowel Disease

Excessive Weight – Muscle Depletion Paradox and Cardiovascular Risk Factors in Outpatients With Inflammatory Bowel Disease

Obesity and Crohn’s disease: what comes first, the egg or the chicken?

The microbiota in inflammatory bowel disease

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