Increased bone mineral density in postmenopausal women with type 2 diabetes mellitus

Hadžibegović, Irzal; Miškić, Blaženka; Ćosić, Vesna; Prvulović, Đeiti; Bistrović, Dragica

doi:10.4103/0256-4947.51739

Cited by 11 publications

(3 citation statements)

References 8 publications

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“…Out of five studies performed in the US, one had included Mexican–American women [6] and one had white and black participants [51]. One study was done in Eastern Asia [7] and another two in Eastern Europe [53, 54]. The remaining eight studies collected data in Western Europe and Oceania.…”

Section: Resultsmentioning

confidence: 99%

Association between bone mineral density and type 2 diabetes mellitus: a meta-analysis of observational studies

et al. 2012

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Type 2 diabetes mellitus (T2DM) influences bone metabolism, but the relation of T2DM with bone mineral density (BMD) remains inconsistent across studies. The objective of this study was to perform a meta-analysis and meta-regression of the literature to estimate the difference in BMD (g/cm 2 ) between diabetic and non-diabetic populations, and to investigate potential underlying mechanisms. A literature search was performed in PubMed and Ovid extracting data from articles prior to May 2010. Eligible studies were those where the association between T2DM and BMD measured by dual energy X-ray absorptiometry was evaluated using a cross-sectional, cohort or case–control design, including both healthy controls and subjects with T2DM. The analysis was done on 15 observational studies (3,437 diabetics and 19,139 controls). Meta-analysis showed that BMD in diabetics was significantly higher, with pooled mean differences of 0.04 (95% CI: 0.02, 0.05) at the femoral neck, 0.06 (95% CI: 0.04, 0.08) at the hip and 0.06 (95% CI: 0.04, 0.07) at the spine. The differences for forearm BMD were not significantly different between diabetics and non-diabetics. Sex-stratified analyses showed similar results in both genders. Substantial heterogeneity was found to originate from differences in study design and possibly diabetes definition. Also, by applying meta-regression we could establish that younger age, male gender, higher body mass index and higher HbA 1C were positively associated with higher BMD levels in diabetic individuals. We conclude that individuals with T2DM from both genders have higher BMD levels, but that multiple factors influence BMD in individuals with T2DM.

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Section: Resultsmentioning

confidence: 99%

Association between bone mineral density and type 2 diabetes mellitus: a meta-analysis of observational studies

et al. 2012

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“…Bone mineral density (BMD) is a good predictor of bone strength because fracture risk is increased with a decrease in BMD [2,3]. BMD was decreased in patients with type 1 diabetes [4], but patients with type 2 diabetes had decreased [5], normal [4] or increased [6] BMD. Unlike patients with type 1 diabetes, the relationship between BMD and fracture risk in patients with type 2 diabetes has not been clear.…”

Section: Introductionmentioning

confidence: 99%

Characteristics of bone turnover, bone mass and bone strength in Spontaneously Diabetic Torii-Lepr fa rats

et al. 2011

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The Spontaneously Diabetic Torii-Lepr (fa) (SDT-fa/fa) rat is a new model of obese type 2 diabetes. The SDT-fa/fa rat shows obesity and hyperglycemia at a young age compared to the Spontaneously Diabetic Torii (SDT-+/+) rat; however, bone abnormalities in the SDT-fa/fa rat have not been investigated. The objective of the present study was to investigate the effects of obese type 2 diabetes on bone turnover, bone mass, and bone strength in the SDT-fa/fa rat. Sprague-Dawley rats were used as control animals, and SDT-+/+ rats were used as non-obese type 2 diabetic rats. Serum osteocalcin and urine deoxypyridinoline levels were decreased in SDT-fa/fa rats compared to control rats at a young age. SDT-fa/fa rats showed decreases in bone mineral density and bone mineral content of the whole tibia, and shortening of the tibia and femur compared to control and SDT-+/+ rats. Deterioration in bone geometrical properties of the femur midshaft such as cortical thickness and minimum moment of inertia, was observed in SDT-fa/fa rats compared to control and SDT-+/+ rats. Furthermore, trabecular bone volume of the distal femur was decreased in SDT-fa/fa rats compared to control rats. These negative effects on bone in SDT-fa/fa rats caused severe decreases in maximum load, stiffness, and energy absorption of the femur. In addition, serum levels of homocysteine, a candidate for bone fragility markers, were elevated in SDT-fa/fa rats compared to control and SDT-+/+ rats. In conclusion, the SDT-fa/fa rat may be a useful model to investigate bone abnormalities in obese type 2 diabetes.

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“…Possible risk factors of osteoporosis are height, weight, body mass index (BMI), a medical history, a family history at mother's side, smoking, an alcohol, and an exercise etc; these are widely analyzed. [7-12]…”

Section: Introductionmentioning

confidence: 99%

Relationship between Weight, Body Mass Index and Bone Mineral Density of Lumbar Spine in Women

Yang¹,

Cho

Park

2012

J Bone Metab

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ObjectivesThis study aims to identify a relationship between bone mineral density (BMD) of lumbar spine, and the weight and body mass index (BMI) in women.MethodsThe subjects were 1,143 females who visited the public health center. BMD (T-score), height and weight were measured and age, menopause, diabetes and hypertension, exercising status and smoking status were inquired by interview.ResultsAmong the subjects, 362 (31.7%) were in the normal group and 781 (68.3%) were in the abnormal group. As the result of the logistic regression analysis with BMI (Model I), the odds ratio of getting into the abnormal BMD group as age increases by 1 year marked 1.044 (95% CI = 1.009-1.080). The odds ratio of getting into the abnormal BMD group due to menopause was 2.663 (1.516-4.679) and the odds ratio according to lack of walking exercise was 2.597 (1.878-3.591). The odds ratio with 1 kg/m2 of BMI increase was 0.909 (0.862-0.959). In the logistic regression analysis with weight (Model II), the odds ratio of getting into the abnormal BMD group as age increases by 1 year marked 1.044 (1.009-1.080). The odds ratio of getting into the abnormal bone density group due to menopause was 2.575 (1.472-4.507) and the odds ratio according to lack of walking exercise was 2.598 (1.881-3.587). The odds ratio with 1 kg of weight increase was 0.963 (0.942-0.984). The Akaike's information criterion (AIC) values of Model I and Model II were 1196.18 and 1197.14 respectively, indicating Model I has the better compatibility of regression analysis model.ConclusionWeight, BMI and BMD had a positive correlation. However, the coefficient of correlation between weight and BMD was higher than the coefficient between BMI and BMD, which means low weight is much more likely to be related to osteoporosis with no other factor considered. On the other hand, under the condition considering age, height, menopause and walking exercise smoking status, low BMI is much more compatible as a risk factor for osteoporosis.

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Increased bone mineral density in postmenopausal women with type 2 diabetes mellitus

Cited by 11 publications

References 8 publications

Association between bone mineral density and type 2 diabetes mellitus: a meta-analysis of observational studies

Association between bone mineral density and type 2 diabetes mellitus: a meta-analysis of observational studies

Characteristics of bone turnover, bone mass and bone strength in Spontaneously Diabetic Torii-Lepr fa rats

Relationship between Weight, Body Mass Index and Bone Mineral Density of Lumbar Spine in Women

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