Increased brain 1H-MRS glutamate and lactate signals following maximal aerobic capacity exercise in young healthy males: an exploratory study

Świątkiewicz, Maciej; Gaździński, Stefan; Madeyski, Michał; Kossowski, Bartosz; Langfort, Józef; Bogorodzki, Piotr; Zawadzka-Bartczak, Ewelina; Sklinda, Katarzyna; Walecki, Jerzy; Grieb, Paweł

doi:10.5114/biolsport.2023.118335

Cited by 5 publications

(5 citation statements)

References 45 publications

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“…Lactate levels in the brain increase following systemic physiological changes, such as during intense exercise 82,83 , and elevated levels are found in pathologies like schizophrenia and depression [84][85][86][87] , which include motivational deficits as one of their core symptoms 53 .…”

Section: Discussionmentioning

confidence: 99%

“…Lactate’s contribution to HME and mental effort sensitivity (kEm) becomes evident in the multivariate context, with its high levels potentially reducing HME choices through mechanisms that extend beyond its traditional role as an energy substrate 81 . Lactate levels in the brain increase following systemic physiological changes, such as during intense exercise 82,83 , and elevated levels are found in pathologies like schizophrenia and depression 84–87 , which include motivational deficits as one of their core symptoms 53 .…”

Section: Discussionmentioning

confidence: 99%

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A neurometabolic signature in the frontal cortex explains individual differences in effort-based decision-making

Barakat,

Clairis,

Brochard

et al. 2024

Preprint

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Exploring why individuals vary in their willingness to exert effort in decision-making is fundamental for understanding human behavior. Our study focuses on the dorsomedial prefrontal cortex/dorsal anterior cingulate cortex (dmPFC/dACC), a crucial brain region in motivation and decision-making, to uncover the neurobiological factors influencing these individual differences. We utilized 7T proton magnetic resonance spectroscopy (1H-MRS) to analyze metabolite concentrations in the dmPFC/dACC and anterior insula (AI) of 75 participants, aiming to predict individual variability in effort-based decision-making. Employing computational modeling, we identified key motivational parameters and, using machine learning models, pinpointed glutamate, aspartate, and lactate as crucial metabolites predicting decision-making to exert high mental effort, signifying their role as potential biomarkers for mental effort decision-making. Additionally, we examined the relationships between plasma and brain metabolite concentrations. Our findings provide novel insights into the neurometabolic underpinnings of motivated behavior, offering new perspectives in the field of cognitive neuroscience and human behavior.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A neurometabolic signature in the frontal cortex explains individual differences in effort-based decision-making

Barakat,

Clairis,

Brochard

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Although cognitive benefits of acute exercise have been demonstrated [ 39 ], others have hypothesised that this effect increases with increasing intervention length [ 37 ], thus raising the possibility that longer intervention periods are necessary to reliably observe changes in Glx. In contrast, a recent study compared Glx levels between two groups: one group remained at rest and one group completed a single intense exercise session [ 40 ]. Interestingly, Glu:Cr and Glx:Cr concentrations were, respectively, 11.0% and 12.6% higher in the exercising group compared to the resting group.…”

Section: Discussionmentioning

confidence: 99%

Effects of acute physical activity on brain metabolites as measured by magnetic resonance spectroscopy (1H-MRS) in humans: A systematic review

Ryberg,

Boraxbekk,

Kjaer

et al. 2023

Heliyon

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“…At the CNS level, a plethora of changes in response to different types of exercise is particularly assigned to the lateral and dorsolateral prefrontal cortex, which takes part in regulating many human executive functions to prepare for situations demanding high levels of working memory, attention and cognitive flexibility (Arsten, 2011;Ludyga et al, 2016). This response can be attributed to the neural activation of dopaminergic, noradrenergic, glutaminergic systems and some neuropeptides (for example BDNF) which play a key role in activation of the prefrontal cortex and thereby cognitive function, as well as to periphery produced substances during exercise (for example lactate or ammonia) which can cross the blood-brain barrier (Arsten, 2011;Świątkiewicz et al, 2023;Zajac et al, 2015). *p < 0.05; *** p < 0.001.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Acute Mild Normobaric Hypoxia and a Single Bout of Exercise to Volitional Exhaustion on Cognitive Performance in Endurance and Strength-Trained Athletes: The role of BDNF, EP-1, Catecholamines and Lactate

Piotrowicz¹,

Czuba²,

Chalimoniuk³

et al. 2023

Journal of Human Kinetics

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The aim of the study was to examine whether a single bout of exercise to volitional exhaustion, performed under moderate normobaric hypoxia (H), would affect psychomotor performance (PP) in differently trained athletes. For this purpose, ten strength-trained (S) athletes, ten endurance-trained (E) athletes and ten healthy men leading a sedentary lifestyle as a control (C) group performed voluntarily two graded exercise tests until volitional exhaustion (EVE) under normoxia (N) and H (FiO2 = 14.7%). We measured the peripheral level of the brain derived neurotrophic factor (BDNF), choice reaction time (CRT) and the number of correct reactions (NCR) as indices of PP. Psychomotor tests were performed at rest, immediately after the EVE and 3 minutes after the EVE. Venous blood samples were collected at rest, immediately after cessation of each EVE, and 1 h after each EVE. The results showed that the EVE significantly (p < 0.05) impaired CRT under N and H, and NCR under H only in the E group. The higher WRmax in the E compared to the S and C groups was associated with a significant (p < 0.005) increase in adrenaline (A) and noradrenaline (NA). There were no significant differences between conditions (N vs. H) in the BDNF at rest and after exercise. The EVE impaired cognitive function only in the E group; higher involvement of the sympathetic nervous system, A and NA may also play a role in this phenomenon. Therefore, it can be concluded that exposure to H did not have a negative impact on CRT or NCR. Moreover, BDNF did not improve cognitive function.

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Increased brain 1H-MRS glutamate and lactate signals following maximal aerobic capacity exercise in young healthy males: an exploratory study

Cited by 5 publications

References 45 publications

A neurometabolic signature in the frontal cortex explains individual differences in effort-based decision-making

A neurometabolic signature in the frontal cortex explains individual differences in effort-based decision-making

Effects of acute physical activity on brain metabolites as measured by magnetic resonance spectroscopy (1H-MRS) in humans: A systematic review

The Impact of Acute Mild Normobaric Hypoxia and a Single Bout of Exercise to Volitional Exhaustion on Cognitive Performance in Endurance and Strength-Trained Athletes: The role of BDNF, EP-1, Catecholamines and Lactate

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