Increased cardiovascular disease risk after exposure to low dose radiation

Auvinen, Anssi

doi:10.1136/bmj-2022-074589

Cited by 3 publications

(3 citation statements)

References 12 publications

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“…A newly published meta-analysis of updated epidemiological data has emphasized more than before the close association between chronic low-dose radiation exposure and CVD [ 7 ]. The analysis showed that low dose radiation and/or low dose rate exposures are associated with an increased risk of CVD per unit dose [ 8 ]. However, underlying molecular mechanisms of CVD caused by chronic low dose rate exposure are not fully known.…”

Section: Discussionmentioning

confidence: 99%

“…The association between CVD and chronic low-dose exposure has been further corroborated by a new comprehensive meta-analysis performed on more recent epidemiological data [ 7 ]. The analysis suggested a higher relative risk per dose unit at low doses and low dose rates [ 7 , 8 ]. However, unlike exposures to high doses, little is known about the biological mechanisms of CVD caused by chronic low doses and low dose rates, such as occupational exposure.…”

Section: Introductionmentioning

confidence: 99%

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Late Effects of Chronic Low Dose Rate Total Body Irradiation on the Heart Proteome of ApoE−/− Mice Resemble Premature Cardiac Ageing

Azimzadeh,

Merl-Pham,

Subramanian

et al. 2023

Cancers

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Recent epidemiologic studies support an association between chronic low-dose radiation exposure and the development of cardiovascular disease (CVD). The molecular mechanisms underlying the adverse effect of chronic low dose exposure are not fully understood. To address this issue, we have investigated changes in the heart proteome of ApoE deficient (ApoE−/−) C57Bl/6 female mice chronically irradiated for 300 days at a very low dose rate (1 mGy/day) or at a low dose rate (20 mGy/day), resulting in cumulative whole-body doses of 0.3 Gy or 6.0 Gy, respectively. The heart proteomes were compared to those of age-matched sham-irradiated ApoE−/− mice using label-free quantitative proteomics. Radiation-induced proteome changes were further validated using immunoblotting, enzyme activity assays, immunohistochemistry or targeted transcriptomics. The analyses showed persistent alterations in the cardiac proteome at both dose rates; however, the effect was more pronounced following higher dose rates. The altered proteins were involved in cardiac energy metabolism, ECM remodelling, oxidative stress, and ageing signalling pathways. The changes in PPARα, SIRT, AMPK, and mTOR signalling pathways were found at both dose rates and in a dose-dependent manner, whereas more changes in glycolysis and ECM remodelling were detected at the lower dose rate. These data provide strong evidence for the possible risk of cardiac injury following chronic low dose irradiation and show that several affected pathways following chronic irradiation overlap with those of ageing-associated heart pathology.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Late Effects of Chronic Low Dose Rate Total Body Irradiation on the Heart Proteome of ApoE−/− Mice Resemble Premature Cardiac Ageing

Azimzadeh,

Merl-Pham,

Subramanian

et al. 2023

Cancers

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“…Currently, it is well-established that high doses of IR, such as those used for radiotherapy can produce direct damage to the heart and arteries, leading to an increased risk of CVD [5][6][7]. However, evidence is emerging that IR exposure may also increase the long-term risk of cardiovascular effects even at low levels of doses less than 0.1 Gray (Gy) or 0.1 sievert (Sv; 1 Sv is equivalent to Gy in medical imaging because the radiation weighting factor for X-rays and gamma rays is 1.0), which are characteristic of doses from medical diagnostic exposures [8,9]. Indeed, the association between CVDs and low-dose exposure has been recently confirmed by a large comprehensive meta-analysis performed on 93 cohort studies, including individuals who had been exposed to radiation in various settings (mostly radiotherapy and occupational exposures, but also diagnostic radiology and environmental exposures).…”

Section: Low-dose Ionizing Radiation and Cardiovascular Diseasementioning

confidence: 99%

Low-doses ionizing radiation exposure: an emerging causal risk factor for cardiovascular disease

Andreassi

2023

Explor Cardiol

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Revisiting an Inverse Dose-Fractionation Effect of Ionizing Radiation Exposure for Ischemic Heart Disease: Insights from Recent Studies

Zablotska,

Little,

Hamada

2024

Radiation Research

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Over the last two decades, there has been emerging evidence suggesting that ionizing radiation exposures could be associated with elevated risks of cardiovascular disease (CVD), particularly ischemic heart disease (IHD). Excess CVD risks have been observed in a number of exposed groups, with generally similar risk estimates at both at low and high radiation doses and dose rates. In 2014, in this journal we reported for the first time significantly higher risks of IHD mortality when radiation doses were delivered over a protracted period of time (an inverse dose-fractionation effect) in the Canadian Fluoroscopy Cohort Study. Here we review the current evidence on the dose-fractionation effect of radiation exposure, discuss potential implication for radiation protection policies and suggest further directions for research in this area.

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Increased cardiovascular disease risk after exposure to low dose radiation

Abstract: These risks should now be considered in radiation protection measures and policies

Cited by 3 publications

References 12 publications

Late Effects of Chronic Low Dose Rate Total Body Irradiation on the Heart Proteome of ApoE−/− Mice Resemble Premature Cardiac Ageing

Late Effects of Chronic Low Dose Rate Total Body Irradiation on the Heart Proteome of ApoE−/− Mice Resemble Premature Cardiac Ageing

Low-doses ionizing radiation exposure: an emerging causal risk factor for cardiovascular disease

Revisiting an Inverse Dose-Fractionation Effect of Ionizing Radiation Exposure for Ischemic Heart Disease: Insights from Recent Studies

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