Increased choroidal thickness: a new feature to monitor age-related macular degeneration recurrence

Bouteleux, V.; Kodjikian, Laurent; Mendes, Maud; Agard, Émilie; Machkour-Bentaleb, Zaïnab; El-Chehab, Hussam; Denis, Philippe; Mathis, Thibaud; Dot, Corinne

doi:10.1007/s00417-018-04216-8

Cited by 11 publications

(9 citation statements)

References 40 publications

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“…We therefore proposed CT as a new indicator of DME recurrence, that could help clinicians to better monitor treatments (Mathis et al 2020). The same observation was previously demonstrated in eyes with exudative AMD (Bouteleux et al 2019). Several hypothetic mechanisms could explain this finding such as the decreased vasodilation of the choroidal vessels due to a reduction of the VEGF‐induced nitric oxide synthesis or the decrease of the intrachoroidal exudation.…”

supporting

confidence: 87%

Variation of choroidal thickness in diabetic macular edema: friend or foe?

Mathis

Dot

Mauget‐Faÿsse

et al. 2020

Acta Ophthalmologica

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supporting

confidence: 87%

Variation of choroidal thickness in diabetic macular edema: friend or foe?

Mathis

Dot

Mauget‐Faÿsse

et al. 2020

Acta Ophthalmologica

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“…Interclass correlation coefficient was also calculated, to assess intergrader agreement through a two-way random-effects model (overall 0.90; range, 0.88-0.91; P , 0.001). All the quantitative data were normalized according to the axial length measured by a IOL Master 500 device (Zeiss, Germany) (mean axial length 23.1; axial length range, [22][23][24].…”

Section: Methodsmentioning

confidence: 99%

Baseline Sattler Layer–choriocapillaris Complex Thickness Cutoffs Associated With Age-Related Macular Degeneration Progression

Amato

Arrigo²,

Borghesan³

et al. 2022

Retina

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To assess the relationship between choroidal overall and sublayer thickness and age-related macular degeneration (AMD) stage progression.Methods: A prospective, observational case series was performed. Two hundred and sixty-two eyes of 262 patients with different stages of AMD were imaged by optical coherence tomography. Age-related macular degeneration stage, choroidal thickness, Sattler layer-choriocapillaris complex thickness (SLCCT), and Haller layer thickness were determined at the baseline visit, at a 1-year follow-up visit, at a 2-year follow up visit, and at a final visit (performed after a mean of 5 ± 1 year from the baseline visit).Results: Baseline AMD stages were distributed as follows: early AMD (30 eyes; 12%), intermediate AMD (97 eyes; 39%), and late AMD (126 eyes; 49%). At the final follow-up, AMD stages were so distributed: early AMD (14 eyes; 6%), intermediate AMD (83 eyes; 33%), and late AMD (156 eyes; 61%). Each group showed a statistically significant decrease in choroidal thickness values over the entire follow-up (P , 0.001), and SLCCT reduction was associated with AMD progression (P , 0.001). Moreover, SLCCT quantitative cutoffs of ,20.50 mm and ,10.5 mm were associated with a moderate and high probability of AMD progression, respectively, and SLCCT quantitative cutoffs of ,18.50 mm and ,8.50 mm implied a moderate and high probability of macular neovascularization onset, respectively.Conclusion: Progressive choroidal impairment contributes to AMD progression. Among choroidal layers, a reduced SLCCT is a promising biomarker of disease worsening, and its quantitative evaluation could help to identify patients at higher risk of stage advancement.

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“…The finding that macular CT is vulnerable to physiological changes identifies the need to find a new way to calibrate CT measurements. Moreover, it remains questionable whether these variations are predictors of macular diseases or whether they are associated with them ( 137 – 139 ), though macular CT measurement has provided new insights into the understanding of macular diseases.…”

Section: Discussionmentioning

confidence: 99%

Choroidal Thickness Profile in Chorioretinal Diseases: Beyond the Macula

Kim

2021

Front. Med.

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Enhanced depth imaging optical coherence tomography (EDI-OCT) and swept-source OCT (SS-OCT) have emerged as essential diagnostic tools in the study and management of various chorioretinal diseases. Evidence from early clinical studies using EDI-OCT and SS-OCT indicates that choroidal dysfunction plays a major role in the pathogenesis of chorioretinal diseases. Measurement of choroidal thickness (CT) has already become a major research and clinical method, and CT is considered as an indicator of choroidal status in a variety of ophthalmic diseases. Recently, CT measurement has also been proposed as a non-invasive marker for the early detection and monitoring of various systemic diseases. Among the several possible CT measurement locations, subfoveal CT has rapidly become a reliable parameter for measuring CT in healthy and diseased eyes. Moreover, recent advancements in OCT technology have enabled faster and wider imaging of the posterior part of the eye, allowing the various changes in CT as measured outside the macula to be shown accordingly. In this review, we first provide an overview of the results of clinical studies that have analyzed the healthy macular choroid and that in various chorioretinal diseases, and then summarize the current understanding of the choroid outside the macula. We also examine the CT profile as an index that encompasses both within and outside of the macula. Furthermore, we describe the clinical applications of ultrawide OCT, which enables visualization of the far periphery, and discuss the prospects for the development of more reliable choroidal parameters that can better reflect the choroid's characteristics.

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Increased choroidal thickness: a new feature to monitor age-related macular degeneration recurrence

Cited by 11 publications

References 40 publications

Variation of choroidal thickness in diabetic macular edema: friend or foe?

Variation of choroidal thickness in diabetic macular edema: friend or foe?

Baseline Sattler Layer–choriocapillaris Complex Thickness Cutoffs Associated With Age-Related Macular Degeneration Progression

Choroidal Thickness Profile in Chorioretinal Diseases: Beyond the Macula

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