Increased chronic pain in patients with ulcerative colitis is mostly associated to increased disease activity. A cross-sectional case-control study

Pettersson, Niclas; Kragsbjerg, Fredrik; Hamrin, A.; Bergman, Stefan; Forsblad-d’Elia, Helena; Karling, Pontus

doi:10.1080/00365521.2020.1820567

Cited by 2 publications

(1 citation statement)

References 33 publications

(37 reference statements)

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“…In addition, although the statistical analyses were adjusted for several chronic physical and psychiatric conditions, other disorders may be involved in the relationship between CLBP and incident TIA and stroke. For example, CLBP is a frequent symptom in osteomyelitis and inflammatory bowel diseases [38,39], and osteomyelitis and inflammatory bowel diseases are risk factors for TIA and stroke [40,41]. Moreover, adults with CLBP are less likely to be physically active than their counterparts without CLBP, and pain and disability may favor the lack of physical activity in the CLBP population [8].…”

Section: Interpretation Of Findingsmentioning

confidence: 99%

Chronic Low Back Pain and Incident Transient Ischemic Attack and Stroke in General Practices in Germany

et al. 2023

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The aim was to investigate the association between chronic low back pain (CLBP) and incident transient ischemic attack (TIA) and stroke in Germany. The present retrospective cohort study included adults aged ≥18 years who were diagnosed for the first time with CLBP in one of 1198 general practices in Germany in 2005–2019 (index date). Patients without CLBP were matched to those with CLBP (1:1) using a propensity score based on age, sex, the index year, the number of medical consultations per year during the follow-up, and the number of years of follow-up. In patients without CLBP, the index date was a randomly selected visit date. Both groups were followed for up to 10 years. There were 159,440 patients included in the study (mean (SD) age: 52.1 (16.5) years; 51.5% women). Within 10 years of the index date, 6.5% and 5.9% of patients with and without CLBP were diagnosed with TIA or stroke, respectively (log-rank p-value < 0.001). The Cox regression analysis corroborated these results, as there was a significant association between CLBP and incident TIA or stroke (HR = 1.28, 95% CI = 1.22–1.35). CLBP was positively and significantly associated with incident TIA and stroke in Germany. More research is warranted to better understand this relationship.

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Section: Interpretation Of Findingsmentioning

confidence: 99%

Chronic Low Back Pain and Incident Transient Ischemic Attack and Stroke in General Practices in Germany

et al. 2023

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Factors associated with chronic abdominal pain in patients with inflammatory bowel disease in remission: A pilot cross‐sectional study

Engelmann‐Kewitz,

Khwaja,

Takahashi

et al. 2024

Neurogastroenterology Motil

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BackgroundPatients (20%–50%) with inflammatory bowel disease (IBD) experience chronic abdominal pain during remission. The clinical features of IBD patients with abdominal pain during remission remain poorly characterized. This cross‐sectional pilot study aimed to assess patient recruitment, adherence, and feedback to optimize questionnaires for future use and to determine the clinical features that distinguish IBD patients in remission with and without abdominal pain.MethodsOnline validated questionnaires about disease activity, symptoms, and psychological factors were sent to participants of the UK National Institute for Health and Care Research (NIHR) IBD BioResource, which is a national research platform consisting of re‐callable IBD patients designed to expedite research into Crohn's and colitis. Inclusion/exclusion criteria of the IBD BioResource main cohort were applied. Descriptive and inferential statistics were applied to participants in remission. p‐values ≤0.01 were considered significant.Key resultsA total of 2050 patients were approached; 291 (14.2%) of these agreed to participate. In 35 patients, technical problems, length, and poor understanding of the relevance of some questionnaires affected completion as confirmed by feedback. In total, 244 patients were full responders with 122 (50%) in remission; 33 (27%) of these had chronic abdominal pain. Comparison of those with versus without (n = 89) chronic abdominal pain yielded higher scores in patients with pain for the following: somatization (p < 0.001); gastrointestinal symptoms rating scale score (p = <0.001); highly sensitive person scale (p = 0.007); catastrophizing score (p = 0.010). Trends were observed for azathioprine use (p = 0.021); coping resources inventory health in general (p = 0.046); neuroticism (p = 0.019); and poor sleep (p = 0.03).Conclusions & inferencesDifferences in symptoms and psychological characteristics exist between IBD patients in remission with and without abdominal pain. Confirmation of findings in larger studies may facilitate development of personalized chronic pain treatments for IBD patients.

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Increased chronic pain in patients with ulcerative colitis is mostly associated to increased disease activity. A cross-sectional case-control study

Cited by 2 publications

References 33 publications

Chronic Low Back Pain and Incident Transient Ischemic Attack and Stroke in General Practices in Germany

Chronic Low Back Pain and Incident Transient Ischemic Attack and Stroke in General Practices in Germany

Factors associated with chronic abdominal pain in patients with inflammatory bowel disease in remission: A pilot cross‐sectional study

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