Increased circulating leukocyte-derived microparticles in ischemic cerebrovascular disease

He, Zhangping; Tang, Yanyan; Qin, Chao

doi:10.1016/j.thromres.2017.03.025

Cited by 37 publications

(25 citation statements)

References 38 publications

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“…LMVs originate from mature leukocytes, including monocyte, lymphocyte, and granulocytes . It is suggested that LMVs are involved in the vascular inflammation in cardiovascular diseases and cerebrovascular diseases including stroke . LMVs can increase the production of TNF‐α, IL‐6, IF‐8, activated protein C, and IF‐1β and induce the translocation of NF‐kβ into the nucleus, leading to increased production of IL‐8 and monocyte chemoattractant protein 1(MCP1), both of which can promote the inflammatory response, leading to vascular endothelial cell dysfunction and vascular permeability.…”

Section: Other Released Signaling From Peripheral Immune Cells That Mmentioning

confidence: 99%

“…It is suggested that LMVs are involved in the vascular inflammation in cardiovascular diseases and cerebrovascular diseases including stroke . LMVs can increase the production of TNF‐α, IL‐6, IF‐8, activated protein C, and IF‐1β and induce the translocation of NF‐kβ into the nucleus, leading to increased production of IL‐8 and monocyte chemoattractant protein 1(MCP1), both of which can promote the inflammatory response, leading to vascular endothelial cell dysfunction and vascular permeability. During cerebral ischemia, circulating MVs increase significantly and cause a large increase in barrier permeability and reduce trans‐epithelial electrical resistance (TEER) in in vitro endothelial barriers .…”

Section: Other Released Signaling From Peripheral Immune Cells That Mmentioning

confidence: 99%

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The peripheral immune response after stroke—A double edge sword for blood‐brain barrier integrity

Zhu

Huang

et al. 2018

CNS Neurosci Ther

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Summary The blood‐brain barrier (BBB) is a highly regulated interface that separates the peripheral circulation and the brain. It plays a vital role in regulating the trafficking of solutes, fluid, and cells at the blood‐brain interface and maintaining the homeostasis of brain microenvironment for normal neuronal activity. Growing evidence has led to the realization that ischemic stroke elicits profound immune responses in the circulation and the activation of multiple subsets of immune cells, which in turn affect both the early disruption and the later repair of the BBB after stroke. Distinct phenotypes or subsets of peripheral immune cells along with diverse intracellular mechanisms contribute to the dynamic changes of BBB integrity after stroke. This review focuses on the interaction between the peripheral immune cells and the BBB after ischemic stroke. Understanding their reciprocal interaction may generate new directions for stroke research and may also drive the innovation of easy accessible immune modulatory treatment strategies targeting BBB in the pursuit of better stroke recovery.

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Section: Other Released Signaling From Peripheral Immune Cells That Mmentioning

confidence: 99%

Section: Other Released Signaling From Peripheral Immune Cells That Mmentioning

confidence: 99%

The peripheral immune response after stroke—A double edge sword for blood‐brain barrier integrity

Zhu

Huang

et al. 2018

CNS Neurosci Ther

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“…Since the refractive index of polystyrene beads is higher than that of MPs, size determination may be affected. Common MP phenotypes measured in plasma are platelet MPs (CD41, CD42a), endothelial‐MPs (CD146, CD144, CD62E) and leucocyte‐MPs (CD45, CD14, CD15, CD4) …”

Section: Assay Of Microparticlesmentioning

confidence: 99%

“…Common MP phenotypes measured in plasma are platelet MPs (CD41, CD42a), 51 endothelial-MPs (CD146, CD144, CD62E) 52 and leucocyte-MPs (CD45, CD14, CD15, CD4). 53 In the assay of MPs, the presence of surface PS is often used to identify particles by staining with annexin V or lactadherin ( Figure 2). Ordinarily, PS resides on the inner surface of the cell membrane but changes caused by influx of calcium during activation and/or apoptosis can lead to its exteriorization on both the cell and the released particles.…”

Section: Assay Of Microparticlesmentioning

confidence: 99%

Microparticles as autoantigens in systemic lupus erythematosus

Mobarrez

Svenungsson

Pisetsky

2018

Eur J Clin Investigation

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Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by the production of antibodies to components of the cell nucleus (antinuclear antibodies or ANAs) and the formation of immune complexes with nuclear antigens. These complexes can drive pathogenesis by depositing in the tissue to incite inflammation or induce cytokine production by cells of the innate immune system. While ANAs can bind to purified nuclear molecules, nuclear autoantigens in vivo most likely exist attached to other molecules or embedded in larger structures. Among these structures, microparticles (MPs) are membrane bound vesicles that are released from dead and dying cells by a blebbing process; MPs can also be released during activation of platelets. The presence of MPs in the blood or tissue culture media can be assayed by flow cytometry on the basis of light scattering as well as binding of marker antibodies to identify the cell of origin. As shown by biochemical analyses, MPs contain an ensemble of intracellular components including nuclear, cytoplasmic and membrane molecules. Because of the display of these molecules on the particle surface or in an otherwise accessible form, ANAs, including anti-DNA, can bind to particles. Levels of MPs are increased in the blood of patients with SLE, with flow cytometry demonstrating the presence of IgG-containing particles. In addition to forming immune complexes, MPs can directly stimulate immune responses. Together, these findings suggest an important role of particles in the pathogenesis of SLE and their utility as biomarkers.

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“…LMVs are increased in states of acute vascular injury such as severe systemic infections and ischemic stroke, as well as after acute exposure to combustible air pollution [154][155][156]. Chronic vascular injury also results in increased levels of LMVs, for example in patients with hyperlipidemia and subclinical atherosclerosis [157,158].…”

Section: Leukocyte Derived Microvesiclesmentioning

confidence: 99%

Electronic cigarettes increase endothelial progenitor cells in the blood of healthy volunteers

et al. 2016

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Increased circulating leukocyte-derived microparticles in ischemic cerebrovascular disease

Cited by 37 publications

References 38 publications

The peripheral immune response after stroke—A double edge sword for blood‐brain barrier integrity

The peripheral immune response after stroke—A double edge sword for blood‐brain barrier integrity

Microparticles as autoantigens in systemic lupus erythematosus

Electronic cigarettes increase endothelial progenitor cells in the blood of healthy volunteers

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