Increased circulating levels of angiotensin-(1–7) in severely ill COVID-19 patients

Martins, Ana Luiza Valle; Silva, Filipe Alex da; Bolais-Ramos, Lucas; Oliveira, Gisele Capanema de; Ribeiro, Renata Cunha; Pereira, Danilo Augusto Alves; Annoni, Filippo; Diniz, Mirella Monique Lana; Silva, Thuanny Granato Fonseca; Zivianni, Bruna; Cardoso, Alexandre Carvalho; Martins, Juliana Carvalho; Motta‐Santos, Daisy; Campagnole‐Santos, Maria José; Taccone, Fabio Silvio; Verano‐Braga, Thiago; Santos, Robson Augusto Souza

doi:10.1183/23120541.00114-2021

Cited by 46 publications

(28 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An investigation found significantly lower activity in COVID-19 patients with respect to controls [79], while other studies found opposite trends [90] or no differences [93]. Opposite results were also observed for the levels of circulating Ang- (1)(2)(3)(4)(5) in two studies: a reduction of about 80% in the COVID-19 class with respect to controls [86], or a 100% increase [82] (see Supplementary Table S1). S1).…”

Section: Meta-analysis On Ras Components In Covid-19mentioning

confidence: 89%

“…The meta-analysis that we carried out in the previous section has shed some light on these questions to a certain extent, but many points remain obscure. Indeed, the experimental and clinical data that we collected from the literature about e.g., the levels of proteins and peptides involved in RAS and the activity of the enzymes, partially disagree [79][80][81][82][83][84][85][86][87][88][89][90][91][92][93][94].…”

Section: Discussionmentioning

confidence: 99%

“…The data collected shows a slightly increased average level of AngII in COVID-19 patients with respect to controls (Table 1). More precisely, roughly half of the studies observe a decrease in AngII levels [82,86,87] and the others, an increase [83,84,89] (Figure 3b). Instead, one would naively expect a general decrease of AngII level, given that ACE2 shows upregulated activity and cleaves AngII.…”

Section: Meta-analysis On Ras Components In Covid-19mentioning

confidence: 92%

“…We review here recent data about measurements of RAS components in COVID-19. For that purpose, we manually collected and screened a series of clinical and experimental results from [79][80][81][82][83][84][85][86][87][88][89][90][91][92][93][94], listed in Supplementary Table S1. The individuals enrolled in these studies were classified into two or three classes: COVID-19 patients or severe and moderate COVID-19 patients, and controls or asymptomatic patients.…”

Section: Meta-analysis On Ras Components In Covid-19mentioning

confidence: 99%

See 3 more Smart Citations

Quantifying Renin-Angiotensin-System Alterations in COVID-19

Pucci

Annoni

Santos

et al. 2021

Cells

Self Cite

View full text Add to dashboard Cite

The renin-angiotensin system (RAS) plays a pivotal role in a wide series of physiological processes, among which inflammation and blood pressure regulation. One of its key components, the angiotensin-converting enzyme 2, has been identified as the entry point of the SARS-CoV-2 virus into the host cells, and therefore a lot of research has been devoted to study RAS dysregulation in COVID-19. Here we discuss the alterations of the regulatory RAS axes due to SARS-CoV-2 infection on the basis of a series of recent clinical investigations and experimental analyzes quantifying, e.g., the levels and activity of RAS components. We performed a comprehensive meta-analysis of these data in view of disentangling the links between the impaired RAS functioning and the pathophysiological characteristics of COVID-19. We also review the effects of several RAS-targeting drugs and how they could potentially help restore the normal RAS functionality and minimize the COVID-19 severity. Finally, we discuss the conflicting evidence found in the literature and the open questions on RAS dysregulation in SARS-CoV-2 infection whose resolution would improve our understanding of COVID-19.

show abstract

Section: Meta-analysis On Ras Components In Covid-19mentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Meta-analysis On Ras Components In Covid-19mentioning

confidence: 92%

Section: Meta-analysis On Ras Components In Covid-19mentioning

confidence: 99%

See 2 more Smart Citations

Quantifying Renin-Angiotensin-System Alterations in COVID-19

Pucci

Annoni

Santos

et al. 2021

Cells

Self Cite

View full text Add to dashboard Cite

show abstract

“…Ang-(1-7) might protect against COVID-19. Specifically, increases in the circulating levels of ACE2 [ 36 ] and Ang-(1-7) [ 37 ] among COVID-19 patients could be a protective mechanism. This notion is supported by Wang et al, who showed that a high Ang-(1-7)/Ang II ratio predicts favorable outcomes in patients with heart failure [ 38 ].…”

Section: Angiotensin 1-7mentioning

confidence: 99%

Alamandine: Potential Protective Effects in SARS-CoV-2 Patients

Hekmat

Javanmardi

2021

J Renin Angiotensin Aldosterone Syst

View full text Add to dashboard Cite

Coronavirus disease 2019 (COVID-19) can occur due to contracting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 has no confined treatment and, consequently, has high hospitalization and mortality rates. Moreover, people who contract COVID-19 present systemic inflammatory spillover. It is now known that COVID-19 pathogenesis is linked to the renin-angiotensin system (RAS). COVID-19 invades host cells via the angiotensin-converting enzyme 2 (ACE2) receptor—as such, an individual’s susceptibility to COVID-19 increases alongside the upregulation of this receptor. COVID-19 has also been associated with interstitial pulmonary fibrosis, which leads to acute respiratory distress, cardiomyopathy, and shock. These outcomes are thought to result from imbalances in angiotensin (Ang) II and Ang-(1-7)/alamandine activity. ACE2, Ang-(1-7), and alamandine have potent anti-inflammatory properties, and some SARS-CoV-2 patients exhibit high levels of ACE2 and Ang-(1-7). This phenomenon could indicate a failing physiological response to prevent or reduce the severity of inflammation-mediated pulmonary injuries. Alamandine, which is another protective component of the RAS, has several health benefits owing to its antithrombogenic, anti-inflammatory, and antifibrotic characteristics. Alamandine alleviates pulmonary fibrosis via the Mas-related G protein-coupled receptor D (MrgD). Thus, a better understanding of this pathway could uncover novel pharmacological strategies for altering proinflammatory environments within the body. Following such strategies could inhibit fibrosis after SARS-CoV-2 infection and, consequently, prevent COVID-19.

show abstract

Patients with severe COVID‐19 have reduced circulating levels of angiotensin‐(1–7): A cohort study

Seyedmehdi

Imanparast

Mohaghegh

et al. 2022

Health Science Reports

View full text Add to dashboard Cite

Background and Aims Angiotensin‐converting enzyme 2 (ACE2) acts as a functional receptor for the entry of severe acute respiratory syndrome coronavirus 2 into host cells. Angiotensin (1–7) (Ang (1–7)) obtained from the function of ACE2 improves heart and lung function. We investigated the relationship between Ang (1–7) level and disease severity in patients with coronavirus disease 2019 (COVID‐19). Methods This cohort study was carried out at Masih Daneshvari Hospital in Tehran, Iran from September 2020 to October 2020. To do so, the Ang (1–7) levels of 331 hospitalized COVID‐19 patients with and without underlying disease were measured by ELISA kit. The need for oxygen, intubation, and mechanical ventilation were recorded for all the patients. Results Results showed a significant inverse relationship between the levels of Ang 1–7 and the severity of the disease (needed oxygen, intubation, and mechanical ventilation). According to the results, median (interquartile range) of Ang (1–7) levels was significantly lower in patients who needed oxygen versus those who needed no oxygen (44.50 (91) vs. 82.25 (68), p = 0.002), patients who needed intubation and mechanical ventilation versus those who did not (9.80 (62) vs. 68.70 (102), p < 0.000) and patients hospitalized in an intensive care unit (ICU) than people hospitalized in other wards. We also found that the older patients were more in need of ICU and mechanical ventilation than younger patients. Conclusions Higher levels of Ang (1–7) have been associated with decreased disease severity. Besides this, we perceived that synthetic Ang 1–7 peptides may be useful to treat and reduce the complications of COVID‐19.

show abstract

Increased circulating levels of angiotensin-(1–7) in severely ill COVID-19 patients

Cited by 46 publications

References 14 publications

Quantifying Renin-Angiotensin-System Alterations in COVID-19

Quantifying Renin-Angiotensin-System Alterations in COVID-19

Alamandine: Potential Protective Effects in SARS-CoV-2 Patients

Patients with severe COVID‐19 have reduced circulating levels of angiotensin‐(1–7): A cohort study

Contact Info

Product

Resources

About