Increased clonogenic potential of circulating endothelial progenitor cells in patients with type 1 diabetes and proliferative retinopathy

Specific Role of Impaired Glucose Metabolism and Diabetes Mellitus in Endothelial Progenitor Cell Characteristics and Function

“…[37][38][39] In contrast, a biphasic pattern in the change of EPCs has also been observed: a decreased number of EPCs seen in nonproliferative retinopathy 40,41 but an increased number and clonogenic potential in patients with DM with proliferative retinopathy. 40,42,43 In patients with type 1 DM and early nonproliferative diabetic retinopathy, only dysregulation of late EPCs with increased clonogenic potential but impairment of homing mechanism is observed. 44 Similarly, functional impairments of EPCs are observed in patients with type 1 40 and type 2 43 DM with proliferative retinopathy despite an increase in their number and clonogenic potential.…”

Correlation of Different Circulating Endothelial Progenitor Cells to Stages of Diabetic Retinopathy: First In Vivo Data

“…Thus far, in T1DM, only an augmented clonogenic potential of mixed precursor cells has been demonstrated in vitro. 27 Thus, an in vivo study of circulating progenitor cells (CPCs), EPCs, and mature EPCs was performed in patients with T1DM carefully investigated for different stages of DR.…”

Endothelial Progenitor Cells Dysfunction in Diabetes Mellitus

“…In contrast, development of insulin resistance, metabolic syndrome and type 2 DM has closely associated with weak ability of EPCs to mobbing, and the lowered level of circulating EPCs was determined [67]. In contrast, Asnaghi V et al (2006) [68] have reported that clonogenic potential of circulating EPCs in patients with type 1 DM may increase. Finally, heterogeneity of EPCs and the variable changes in the EPCs' phenotypes at the different stages of CV disease and development of DM are limiting factors to determine the predictive value of count and functionality of EPCs in CV risk calculation.…”