Increased collagen degradation predicts early ventricular remodelling following acute myocardial infarction

McGavigan, Andrew D.; Moncrieff, Joanne; Maxwell, Paul R.; Lindsay, Martin M.; Dunn, Francis G.

doi:10.1016/s0735-1097(02)81462-0

Cited by 3 publications

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We agree with Turhan and colleagues that the results from our clinical observational study are consistent with other works on collagen metabolism following infarction [1]. They highlight the importance of matrix metalloproteinase (MMP) activity in collagen homeostasis.

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confidence: 93%

Reply to “Ventricular remodelling following acute myocardial infarction: The role of altered collagen homeostasis"

McGavigan

2007

International Journal of Cardiology

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confidence: 93%

Reply to “Ventricular remodelling following acute myocardial infarction: The role of altered collagen homeostasis"

McGavigan

2007

International Journal of Cardiology

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“…Matrix metalloproteinase gene expression is upregulated within a few hours of infarction (21), and the results of the present study suggest that plasma levels of CITP mirror the changes occurring at a tissue level and reflect the early remodelling process. Given the rapid, exponential rise of plasma CITP levels within a short time period, coupled with the fact that admission CITP values predict the subsequent development of wall motion abnormalities in ST elevation myocardial infarction (13), the present study may support the use of early biochemical assessment as a means to identify those at risk of subsequent adverse ventricular remodelling.…”

Section: Discussionmentioning

confidence: 68%

“…This was due to the fact that elective diagnostic coronary angiography was performed as a day case and, therefore, a 16 h sample would have been impractical. In addition, it was observed in previous studies (11)(12)(13) that changes in plasma markers of collagen turnover are apparent within 6 h of the onset of ischemic symptoms.…”

Section: Blood Sampling and Biochemical Analysesmentioning

confidence: 83%

“…However, these are stable, chronic conditions with alterations occurring slowly over a period of time in contrast to the rapid changes seen in acute ischemic events (11,12). Although the study numbers are small, the study was designed to provide insight into the early temporal dynamics of these markers and additional information to our previously published work in the setting of acute myocardial infarction (11,13) and non-ST elevation acute coronary syndromes (12).…”

Section: Discussionmentioning

confidence: 99%

“…We have previously shown time-dependent changes in plasma levels of PICP and CITP following ST elevation myocardial infarction (11) and non-ST elevation acute coronary syndromes (12), and demonstrated that these plasma markers of collagen turnover may be useful in the noninvasive assessment of left ventricular remodelling (13).…”

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confidence: 99%

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Time course of early changes in plasma markers of collagen turnover following percutaneous transluminal coronary angioplasty

McGavigan

Maxwell

Dunn

2010

Canadian Journal of Cardiology

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Changes to the collagen framework of the heart occur following myocardial infarction, with as much as 25% net collagen loss within the first 24 h (1). These changes are associated with the development of ventricular remodelling (2,3), which is associated with an adverse prognosis (4-6).Type I collagen is the most abundant subtype within the heart (7). Its metabolism can be assessed biochemically by analysis of plasma levels of procollagen type I carboxyterminal propeptide (PICP) (8,9) as a marker of synthesis, and C-telopeptide for type I collagen (CITP) as a marker of breakdown (10).We have previously shown time-dependent changes in plasma levels of PICP and CITP following ST elevation myocardial infarction (11) and non-ST elevation acute coronary syndromes (12), and demonstrated that these plasma markers of collagen turnover may be useful in the noninvasive assessment of left ventricular remodelling (13).In these studies, the changes in plasma levels of CITP and PICP were apparent from admission, despite all patients being recruited within 6 h of the onset of symptoms, suggesting that collagen remodelling occurs within a few hours of the ischemic stimulus. As such, the remodelling process may be amenable to early biochemical assessment, but the exact early temporal dynamics of these plasma markers are unclear. To investigate this further, we examined the early time course of plasma levels of CITP and PICP in a human model of controlled acute coronary artery occlusion by recruitment of a cohort of patients undergoing percutaneous coronary intervention (PCI), and performed sequential blood sampling to assess temporal dynamics of plasma CITP and PICP. InTRoDuCTIon: Marked changes occur in the collagen framework of the heart following acute ischemia, which is associated with adverse ventricular remodelling. Plasma markers of collagen turnover are useful in the assessment of remodelling and have predictive value, but their exact temporal dynamics following ischemia are unclear. obJeCTIve: To characterize the early temporal dynamics of plasma markers of collagen turnover in a human model of coronary artery occlusion. MeThoDs: Fourteen patients undergoing elective percutaneous coronary intervention (PCI) to a single coronary artery were recruited in addition to a control group of eight patients undergoing elective diagnostic coronary arteriography. Sequential assessment of plasma levels of procollagen type I carboxyterminal propeptide and C-telopeptide for type I collagen (CITP) as markers of synthesis and degradation, respectively, was performed over a 16 h period. ResulTs: The ischemic burden in the PCI group was high, with 13 of the 14 patients demonstrating transient ST segment shift or positive troponin. Mean plasma levels of CITP on admission were 3.1 ng/mL and 3.0 ng/mL in the PCI and control groups, respectively (P value nonsignificant). There was a sequential increase in plasma CITP following PCI, peaking at 4.7 ng/mL at 16 h (P<0.01), with no change in the control group. There were no significant changes in...

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Serological evidence of early remodeling in high-risk non-ST elevation acute coronary syndromes

McGavigan

Maxwell

Dunn

2008

International Journal of Cardiology

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Increased collagen degradation predicts early ventricular remodelling following acute myocardial infarction

Cited by 3 publications

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Reply to “Ventricular remodelling following acute myocardial infarction: The role of altered collagen homeostasis"

Reply to “Ventricular remodelling following acute myocardial infarction: The role of altered collagen homeostasis"

Time course of early changes in plasma markers of collagen turnover following percutaneous transluminal coronary angioplasty

Serological evidence of early remodeling in high-risk non-ST elevation acute coronary syndromes

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