Increased concentrations of octachlorodibenzo-p-dioxin in cases with breast cancer — results from a case—control study

Hardell, Lennart; Lindström, Gunilla; Liljegren, G; Dahl, Per Erling; Magnuson, Anders

doi:10.1097/00008469-199610000-00007

Cited by 29 publications

(18 citation statements)

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“…No difference was found between cases and controls for most isomers of the dioxins, PCDDs and PCDFs. However, in one study, contrary to expectation, the levels of octachlorinated dibenzo-p-dioxin (OCDD) were slightly elevated in the cases (45).…”

Section: Population-based Case-control Studiesmentioning

confidence: 68%

Environmental Risk Factors and Female Breast Cancer

Laden

Hunter

1998

Annu. Rev. Public Health

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The increasing incidence of breast cancer in the United States and the international variation in risk have led to speculation that environmental risk factors are an important cause of breast cancer. We review the epidemiologic evidence on the breast cancer risk associated with ambient environmental exposures experienced passively by the US population, and discuss the difficulties associated with measurement of specific exposures in environmental studies. We review geographic variation of breast cancer rates in the United States, and exposure to organochlorines, ionizing and electromagnetic radiation, and passive smoking. Results are inconclusive but do not support a major role of environmental risk factors in the etiology of breast cancer.

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Section: Population-based Case-control Studiesmentioning

confidence: 68%

Environmental Risk Factors and Female Breast Cancer

Laden

Hunter

1998

Annu. Rev. Public Health

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“…Detection levels for dioxins are in the low pg/g range and for P,CBS and OCPS in the low rig/g range. Our techniques permitted measurements of the target chemicals at levels well below those reported in the literature for the general population (Dewailly et al, 1994;Harden et al, 1996). Lipid content was determined by the gravimetric method in an aliquot of the extract.…”

Section: Lbnl43755mentioning

confidence: 99%

Comparison of organochlorine chemical body burdens of female breast cancer cases with cancer free women in Rio Grande do Sul, Brazil--Pilot Study

Erdmann¹,

Petreas²,

Caleffi³

et al. 1999

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“…However, a hospital-based breast cancer case-control study found no difference in breast tissue concentration of TCDD between women with breast cancer and women with benign breast disease, but the level of exposure was low (1.0-7.9 ppt, lipid-adjusted) (10). On 10 July 1976, an explosion at a trichlorophenol manufacturing plant near Seveso, Italy, resulted in the highest TCDD levels known in human residential populations (11).…”

mentioning

confidence: 99%

Serum dioxin concentrations and breast cancer risk in the Seveso Women's Health Study.

Warner

Eskenazi

Mocarelli

et al. 2002

Environ Health Perspect

209

109

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2,3,7,8-Tetrachlorodibenzo-(italic)p(/italic)-dioxin (TCDD or dioxin), a widespread environmental contaminant, has been shown to disrupt multiple endocrine pathways. The International Agency for Research on Cancer classified TCDD as a known human carcinogen, primarily based on occupational studies of increased mortality from all cancers combined. Using data from the Seveso Women's Health Study (SWHS), we examined the association between individual serum TCDD levels and breast cancer risk in women residing around Seveso, Italy, in 1976, at the time of an industrial explosion that resulted in the highest known population exposure to TCDD. The SWHS cohort comprises 981 women who were infants to 40 years old in 1976, resided in the most contaminated areas at the time of the explosion, and had archived sera that was collected soon after the explosion. For each woman, serum TCDD exposure was measured by high-resolution mass spectrometry. Cancer cases were identified during interview and confirmed by medical record. At interview, 15 women (1.5%) had been diagnosed with breast cancer and serum TCDD levels for cases ranged from 13 to 1,960 ppt. Cox proportional hazards modeling showed that the hazard ratio for breast cancer associated with a 10-fold increase in serum TCDD levels (log(subscript)10(/subscript) TCDD) was significantly increased to 2.1 (95% confidence interval, 1.0-4.6). Covariate-adjusted results were not different. Individual serum TCDD is significantly related with breast cancer incidence among women in the SWHS cohort. Continued follow-up of the cohort will help shed light on the possible role of TCDD in the pathogenesis of breast cancer.

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Increased concentrations of octachlorodibenzo-p-dioxin in cases with breast cancer — results from a case—control study

Cited by 29 publications

References 0 publications

Environmental Risk Factors and Female Breast Cancer

Environmental Risk Factors and Female Breast Cancer

Comparison of organochlorine chemical body burdens of female breast cancer cases with cancer free women in Rio Grande do Sul, Brazil--Pilot Study

Serum dioxin concentrations and breast cancer risk in the Seveso Women's Health Study.

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