Increased connectivity between sensorimotor and attentional areas in Parkinson’s disease

Onu, Mihaela; Badea, Liviu; Roceanu, Adina; Tivarus, Madalina E.; Băjenaru, Ovidiu

doi:10.1007/s00234-015-1556-y

Cited by 34 publications

(30 citation statements)

References 67 publications

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“…All our patients were on optimal l ‐dopa medication at the time of the MRI scan. For this reason, we cannot make any inferences on the acute effects of l ‐dopa on the underlying pathophysiology, as was demonstrated in other reports that compared changes in fcMRI before and after l ‐dopa administration . In contrast with most of these reports, our patients had advanced PD with severe motor fluctuations and, not infrequently, freezing of gait.…”

Section: Discussionmentioning

confidence: 58%

“…The pattern of fcMRI changes shown in our study is supported by findings from a recent study that looked at differences in “networks” identified on independent components analysis in 27 PD patients and 16 controls. A significant functional connectivity increase in patients between the sensorimotor network and the spatial attention network in the parietal cortex was found and was correlated with UPDRS‐III . Furthermore, l ‐dopa has been shown to restore fcMRI in the sensorimotor network, especially in the SMA, when administered to drug‐naive patients …”

Section: Discussionmentioning

confidence: 95%

“…The shared findings of studies that investigated the way fcMRI is influenced by l ‐dopa in PD point toward an abnormal fcMRI pattern that is relatively restored following l ‐dopa administration. We propose that the contrasting patterns of functional connectivity that we have observed in association with l ‐dopa responsiveness are a reflection of the relative degrees of normalization of functional connectivity with dopamine therapy.…”

Section: Discussionmentioning

confidence: 95%

“…To date, several fcMRI studies have examined the connectivity profile in patients with PD compared with healthy controls and the effect l ‐dopa therapy has on the connectivity pattern . All but one of these studies were on patients in the early stages of PD.…”

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confidence: 99%

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l-Dopa responsiveness is associated with distinctive connectivity patterns in advanced Parkinson's disease

Akram

Hyam

et al. 2017

Mov Disord.

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Our findings show characteristic basal ganglia resting-state functional connectivity patterns associated with different degrees of l-dopa responsiveness in patients with advanced Parkinson's disease. l-Dopa exerts a graduated influence on remapping connectivity in distinct motor control networks, potentially explaining some of the variance in treatment response. © 2017 International Parkinson and Movement Disorder Society.

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Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 95%

mentioning

confidence: 99%

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l-Dopa responsiveness is associated with distinctive connectivity patterns in advanced Parkinson's disease

Akram

Hyam

et al. 2017

Mov Disord.

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“…The aim of the present study was to further delineate functional abnormalities in DYT1 symptomatic and asymptomatic mutation carriers using resting‐state MRI with dual regression approach as well as between‐network relationship with the (as a toolbox of FSL, with Nets is referred to “networks”) (FSLNets) (http://fsl.fmrib.ox.ac.uk/fsl/fslwiki/FSLNets) package . By this novel approach to genetic dystonia, we evaluated the intrinsic network signature and symptom‐related changes in DYT1 mutation to explore (1) at‐rest functional brain networks alterations that characterized the different phases of DYT1 disease (considering asymptomatic DYT1 carriers [a DYT1 ] and dystonic patients bearing DYT1 mutation [d DYT1 ]) and (2) complex mutual association among brain functional networks involved in DYT1 disease.…”

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confidence: 99%

Functional Connectivity Networks in Asymptomatic and Symptomatic DYT1 Carriers

et al. 2016

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Background: DYT1 mutation is characterized by focal to generalized dystonia and incomplete penetrance. To explore the complex perturbations in the different neu-ral networks and the mutual interactions among them, we studied symptomatic and asymptomatic DTY1 mutation carriers by resting-state functional MRI. Methods: A total of 7 symptomatic DYT1, 10 asymp-tomatic DYT1, and 26 healthy controls were consid-ered. Resting-state functional MRI (Oxford Centre for Functional MRI of the Brain) [FMRIB] Software Library) (FSL) MELODIC, dual regression, (as a toolbox of FSL, with Nets is referred to "networks") (FSLNets) (http:// fsl.fmrib.ox.ac.uk/fsl/fslwiki/FSLNets) was performed on 9 resting-state neural networks. Results: DYT1 mutation signature (symptomatic DYT1 and asymptomatic DYT1) was characterized by increased connectivity in the dorsal attention network and in the left fronto-parietal network. Functional corre-lates of symptomatic DYT1 patients (symptomatic DYT1 vs healthy controls) showed increased connec-tivity in the sensorimotor network. Discussion: This study argues that DYT1 dystonia is a network disorder, with crucial nodes in sensorymotor integration of posterior parietal structures. A better characterization of cortical networks involved in dysto-nia is crucial for possible neurophysiological therapeu-tic interventions. V C 2016 International Parkinson and Movement Disorder Society

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Characterizing resting‐state networks in Parkinson’s disease: A multi‐aspect functional connectivity study

2021

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Purpose Resting‐state functional magnetic resonance imaging (Rs‐fMRI) can be used to investigate the alteration of resting‐state brain networks (RSNs) in patients with Parkinson's disease (PD) when compared with healthy controls (HCs). The aim of this study was to identify the differences between individual RSNs and reveal the most important discriminatory characteristic of RSNs between the HCs and PDs. Methods This study used Rs‐fMRI data of 23 patients with PD and 18 HCs. Group independent component analysis (ICA) was performed, and 23 components were extracted by spatially overlapping the components with a template RSN. The extracted components were used in the following three methods to compare RSNs of PD patients and HCs: (1) a subject‐specific score based on group RSNs and a dual‐regression approach (namely RSN scores); (2) voxel‐wise comparison of the RSNs in the PD patient and HC groups using a nonparametric permutation test; and (3) a hierarchical clustering analysis of RSNs in the PD patient and HC groups. Results The results of RSN scores showed a significant decrease in connectivity in seven ICs in patients with PD compared with HCs, and this decrease was particularly striking on the lateral and medial posterior occipital cortices. The results of hierarchical clustering of the RSNs revealed that the cluster of the default mode network breaks down into the three other clusters in PD patients. Conclusion We found various characteristics of the alteration of the RSNs in PD patients compared with HCs. Our results suggest that different characteristics of RSNs provide insights into the biological mechanism of PD.

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Increased connectivity between sensorimotor and attentional areas in Parkinson’s disease

Abstract: Our results show higher connectivity between sensorimotor and spatial attention areas in patients that may be related to the reduced movement automaticity in PD.

Cited by 34 publications

References 67 publications

l-Dopa responsiveness is associated with distinctive connectivity patterns in advanced Parkinson's disease

l-Dopa responsiveness is associated with distinctive connectivity patterns in advanced Parkinson's disease

Functional Connectivity Networks in Asymptomatic and Symptomatic DYT1 Carriers

Characterizing resting‐state networks in Parkinson’s disease: A multi‐aspect functional connectivity study

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