Increased Consumption of Sulfur Amino Acids by Both Sows and Piglets Enhances the Ability of the Progeny to Adverse Effects Induced by Lipopolysaccharide

Zhang, Ying; Xu, Baoyang; Zhao, Liancheng; Zhu, Luoyi; Batonon-Alavo, Dolores I.; Jachacz, J.; Qi, Desheng; Zhang, Shujun; Ma, Libao; Sun, Luo

doi:10.3390/ani9121048

Cited by 10 publications

(18 citation statements)

References 43 publications

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“…At the end of the feeding trial and after 12 h of feed deprivation, 10 male pigs (1 pig/pen) from each treatment were selected according to the treatment average BW for the analysis of the carcass traits and meat quality. The backfat thickness of the pigs was measured 65 mm from the left side of the dorsal midline at the last rib level (P2) by an ultrasound (Renco B-07, Minneapolis, MN, USA), according to Zhang et al (2019) [ 22 ]. The selected pigs were weighed and sacrificed using electrical stunning (120 V, 200 Hz) and exsanguination.…”

Section: Methodsmentioning

confidence: 99%

A Multicarbohydrase and Phytase Complex Is Able to Compensate a Nutrient-Deficiency in Growing-Finishing Pigs

Huang

Zhao

Sun

et al. 2021

Animals

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The objective of this study was to evaluate the efficacy of supplementing a corn-wheat-soybean meal-based diet with a multicarbohydrase and phytase complex (MCPC) on growth performance, apparent total tract digestibility (ATTD) of nutrients, carcass traits, and meat quality in growing-finishing pigs. A total of 300 pigs (Duroc × Large White × Landrace; body weight = 25.3 ± 0.7 kg) were randomly allotted to three groups with 10 replicates of 10 pigs each. Pigs from three groups were fed positive control (PC) or negative control (NC), without or with MCPC diets, respectively. The MCPC supplied at least 1800, 1244, 6600, and 1000 units of xylanase, β-glucanase, α-arabinofuranosidase, and phytase per kilogram of diet, respectively. The NC diet was the PC diet but reduced in net energy (NE), digestible amino acids (dig. AA), digestible P (dig. P), and Ca by 74 kcal/kg, 7.0%, 0.134, and 0.119 percentage points, respectively. The diets were fed in 4 growth phases based on body weight (BW): phase 1: 25–50 kg, phase 2: 50–75 kg, phase 3: 75–100 kg, and phase 4: 100–135 kg. Compared to the PC, the NC diet decreased (p < 0.05) body weight gain, feed intake, and(or) feed to gain ratio during the growing/finishing phases 1, 2, 3, and 4. It also reduced (p < 0.05) the ATTD of crude protein, crude fat, P, and Ca of pigs. MCPC supplementation improved (p < 0.05) the body weight gain, feed intake, and(or) feed to gain ratio in phases 2, 3, and 4 and the ATTD of crude protein, crude fat, ash, P, and Ca for the NC diet. Additionally, dietary treatment had no effects on carcass traits and meat quality with the exception that the loin eye area in the NC plus MCPC diet was higher (p < 0.05) than the NC diet. In conclusion, the addition of MCPC to a corn-soybean meal-wheat-based diet reduced in energy and nutrients improved the growth performance and nutrient digestibility but had little effect on carcass traits and meat quality in growing-finishing pigs.

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Section: Methodsmentioning

confidence: 99%

A Multicarbohydrase and Phytase Complex Is Able to Compensate a Nutrient-Deficiency in Growing-Finishing Pigs

Huang

Zhao

Sun

et al. 2021

Animals

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“…Methionine plays a part in the main functions in the body, including ROS elimination and GSH precursors [ 37 ], and thus methionine is sensitive to oxidative modification [ 38 , 39 , 40 ]. The results of previous investigations pointed out that augmented dietary Met levels exerted antioxidant impacts in poultry.…”

Section: Discussionmentioning

confidence: 99%

Effects of Varying Dietary DL-Methionine Levels on Productive and Reproductive Performance, Egg Quality, and Blood Biochemical Parameters of Quail Breeders

Reda

Swelum

Hussein

et al. 2020

Animals

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The present study was carried out to study the effects of varying dietary DL-methionine (0, 0.5, 1.5, 2.5, and 3.5 g/kg) levels on the productive and reproductive performance, egg quality and blood biochemical parameters of quail breeders. In total, 150 mature Japanese quails at eight weeks of age were randomly allotted to five groups of 30 for each group. Each group included five replicates, each of six quails (four females and two males). The results showed that egg number, egg weight and egg mass were higher (p < 0.05) with the addition of all DL-methionine levels than that of the control group. Quails from the control group had a lower feed intake (p < 0.001) and a worse feed conversion ratio (FCR) than those from the DL-methionine-treated groups. Supplementation of DL-methionine up to 2.5 g/kg in quail diets increased fertility and hatchability percentages. Birds fed DL-methionine at 1.5 g/kg had the best egg production indices, better FCR and the highest values of fertility and hatchability. Egg weight, yolk %, Haugh unit, egg shape index and unit surface shell weight (USSW) were increased and eggshell % was decreased in quail supplemented with DL-methionine levels compared with the control quail (p < 0.05). Dietary DL-methionine levels did not affect (p > 0.05) the hemoglobin (Hb), red blood cells (RBCs), white blood cells (WBCs) and packed cell volume (PCV) of quails. DL-methionine levels (0.5 and 2.5 g/kg) augmented lymphocytes and basophile (p < 0.05). Low DL-methionine levels (0.5 or 1.5 g/kg) improved liver enzymes and kidney functions. Dietary DL-methionine levels (except 3.5 g/kg) declined serum lactate dehydrogenase (LDH) and decreased lipid profile parameters (except high-density lipoprotein—HDL). Supplementation of DL-methionine at 0.5 and 1.5 g/kg increased immunoglobulin (IgG, IgM and IgA) and superoxide dismutase (SOD), total antioxidant capacity (TAC), catalase (CAT) and reduced glutathione (GSH) (p < 0.001) compared with the control. In conclusion, dietary supplementation of DL-methionine (1.5 g/kg) can enhance the reproductive performance and egg quality of quail breeders. DL-methionine use at levels of 0.5 or 1.5 g/kg improved the liver and kidney functions, lipid profile, immunity and antioxidant parameters of Japanese quail.

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“…It is the second or third most limiting amino acid for pigs that are fed corn-soybean meal diets [ 2 , 3 ]; it is used for protein synthesis and is involved in the methylation reactions of DNA and choline metabolism [ 4 , 5 ]. Additionally, methionine acts as the precursor for glutathione and taurine and plays a critical role in antioxidant defense and regulates immune responses in various animal species [ 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…The bacterial endotoxin lipopolysaccharide (LPS) can induce inflammation and oxidative stress, which causes damage to different organs and leads to adverse effects on animal productivity [ 10 ]. Our previous study showed that an increased consumption of methionine by both maternal and neonatal pigs can improve the capability of the progeny to cope with the LPS-induced negative effects [ 8 ]. However, the underlining mechanisms in this regard remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Increased Ingestion of Hydroxy-Methionine by Both Sows and Piglets Improves the Ability of the Progeny to Counteract LPS-Induced Hepatic and Splenic Injury with Potential Regulation of TLR4 and NOD Signaling

Zhang

Cao

et al. 2022

Antioxidants

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Methionine, as an essential amino acid, play roles in antioxidant defense and the regulation of immune responses. This study was designed to determine the effects and mechanisms of increased consumption of methionine by sows and piglets on the capacity of the progeny to counteract lipopolysaccharide (LPS) challenge-induced injury in the liver and spleen of piglets. Primiparous sows (n = 10/diet) and their progeny were fed a diet that was adequate in sulfur amino acids (CON) or CON + 25% total sulfur amino acids as methionine from gestation day 85 to postnatal day 35. A total of ten male piglets were selected from each treatment and divided into 2 groups (n = 5/treatment) for a 2 × 2 factorial design [diets (CON, Methionine) and challenge (saline or LPS)] at 35 d old. After 24 h challenge, the piglets were euthanized to collect the liver and spleen for the histopathology, redox status, and gene expression analysis. The histopathological results showed that LPS challenge induced liver and spleen injury, while dietary methionine supplementation alleviated these damages that were induced by the LPS challenge. Furthermore, the LPS challenge also decreased the activities of GPX, SOD, and CAT and upregulated the mRNA and(or) protein expression of TLR4, MyD88, TRAF6, NOD1, NOD2, NF-kB, TNF-α, IL-8, p53, BCL2, and COX2 in the liver and (or) spleen. The alterations of GPX and SOD activities and the former nine genes were prevented or alleviated by the methionine supplementation. In conclusion, the maternal and neonatal dietary supplementation of methionine improved the ability of piglets to resist LPS challenge-induced liver and spleen injury, potentially through the increased antioxidant capacity and inhibition of TLR4 and NOD signaling pathway.

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Increased Consumption of Sulfur Amino Acids by Both Sows and Piglets Enhances the Ability of the Progeny to Adverse Effects Induced by Lipopolysaccharide

Cited by 10 publications

References 43 publications

A Multicarbohydrase and Phytase Complex Is Able to Compensate a Nutrient-Deficiency in Growing-Finishing Pigs

A Multicarbohydrase and Phytase Complex Is Able to Compensate a Nutrient-Deficiency in Growing-Finishing Pigs

Effects of Varying Dietary DL-Methionine Levels on Productive and Reproductive Performance, Egg Quality, and Blood Biochemical Parameters of Quail Breeders

Increased Ingestion of Hydroxy-Methionine by Both Sows and Piglets Improves the Ability of the Progeny to Counteract LPS-Induced Hepatic and Splenic Injury with Potential Regulation of TLR4 and NOD Signaling

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