Increased Cord Blood Betatrophin Levels in the Offspring of Mothers with Gestational Diabetes

Xie, Xuemei; Gao, Hongjie; Wu, Shimin; Zhao, Yue; Du, Caiqi; Yuan, Guandou; Qin, Ning; McCormick, Kenneth; Luo, Xiaoping

doi:10.1371/journal.pone.0155646

Cited by 14 publications

(20 citation statements)

References 52 publications

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“…Similarly, Erol et al found the ANGPTL8 level was significantly higher in 45 pregnant women diagnosed with GDM compared with 45 healthy pregnant women matched for BMI and gestational age . Other studies have shown that ANGPTL8 level was increased in the cord blood from women with GDM compared with healthy women at delivery …”

Section: Angptl8 Role In Diabetesmentioning

confidence: 88%

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ANGPTL8 (betatrophin) role in diabetes and metabolic diseases

Abu‐Farha

Abubaker

Tuomilehto

2017

Diabetes Metabolism Res

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Diabetes is a major disease worldwide that is reaching epidemic levels. Its increased prevalence as well as its association with a high number of complications such as cardiovascular diseases, nephropathy, and retinopathy makes it an important disease for investigation. ANGPTL8 is a recently identified hormone that has been associated with two functionally important processes in the development of type 2 diabetes, insulin resistance as well as lipid metabolism. Initial work has shown that ANGPTL8 was expressed in liver, white adipose, and brown adipose tissues. ANGPTL8 regulates the activity of lipoprotein lipase, which is a key enzyme in lipoprotein lipolysis pathway through its direct interaction with ANGPTL3. It has been also reported that it regulates the replication of β-cells in response to insulin resistance. As a result, many recent studies have focused on the association of ANGPTL8 with diabetes and obesity as well as its association with various metabolic markers in order to better understand its physiological role in glucose homeostasis and lipid metabolism. In this review, we will highlight some of the key clinical findings, mainly from human studies, that investigated the role of ANGPTL8 in metabolic diseases such as diabetes, obesity, and the metabolic syndrome.

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Section: Angptl8 Role In Diabetesmentioning

confidence: 88%

“…has been found to be increased in women with gestational diabetes (GDM) either in blood circulation 57,[59][60][61] or cord blood 60,61 as summarized in Table 2. Consistently, ANGPTL8 has been initially shown to be increased during gestation in a mouse model.…”

Section: Angptl8 Role In Diabetesmentioning

confidence: 99%

ANGPTL8 (betatrophin) role in diabetes and metabolic diseases

Abu‐Farha

Abubaker

Tuomilehto

2017

Diabetes Metabolism Res

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“…As mentioned above, the impact of betatrophin on insulin resistance seems still far from clear. In recent years, a great deal of researches indicate that there is a positive correlation between this protein and insulin resistance in patients with T2DM, GDM, and other diseases [12][13][14][15][16][17][18][19]. However, many inconsistent findings are also reported in other studies [10,[20][21][22].…”

Section: The Correlation Between Circulating Betatrophin and Insulin mentioning

confidence: 99%

“…Of these studies included, 12 studies recruited patients with T2DM [8, 9, 12-14, 20, 22-27], of which one recruited patients undergoing CD [13], and 5 enrolled GDM [15,16,[28][29][30], 3 enrolled PCOS [17,21,31], 2 enrolled adult with different body weight (BW) [10,32], one enrolled Mets [18] and 2 enrolled NAFLD [19,33]. Twenty-two studies in all included studies were cross-sectional studies, 3 were case control studies.…”

Section: Description Of Included Studiesmentioning

confidence: 99%

The Correlation Between Circulating Betatrophin and Insulin Resistance in General Population: A Meta-Analysis

Lin

Zhou

et al. 2017

Horm Metab Res

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Many inconsistent findings are reported on the correlation between circulating betatrophin and insulin resistance in the different population. The aim of this analysis was to explore the correlation between the level of betatrophin and insulin resistance in the general population. The databases of PubMed, EMBASE, and the Cochrane Library (inception to October 26, 2016) were searched without language restrictions for publications that reported studies on associations between betatrophin and insulin resistance in adults. Subgroup analyses were performed to investigate potential sources of heterogeneity. The pooled effect size was calculated using a random-effects model. Twenty-five studies were included in this meta-analysis. Meta-analysis showed that betatrophin was positively and significantly correlated with insulin resistance (r=0.16, 95% CI: 0.08-0.25). When all participants were divided into DM, GDM, and Non-DM groups, this association was also significant in T2DM, GDM, and Non-DM participants (T2DM: r=0.09, 95% CI: 0.01-0.17; I =45.1%; GDM: r=0.39, 95% CI: 0.24-0.55; I=0.0%; non-DM: r=0.15, 95% CI: 0.04-0.26; I =89.3%), and it was obvious that heterogeneity existed in Non-DM group (I=89.3%, p<0.001). Subgroup analysis revealed that gender, serum sample and ELISA kits for full-length betatrophin had significant influence on the association between betatrophin and insulin resistance. In conclusion, the level of circulating betatrophin is positively associated with insulin resistance in the general population, especially in T2DM and GDM patients. Gender, serum sample, and ELISA kits for full-length betatrophin may affect this association. More large-scale studies are needed to determine whether improving insulin resistance concomitantly declines betatrophin levels in different diseases.

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“…Several studies revealed that GDM women showed higher levels of betatrophin than control subjects [13–18, 20], indicating that augmented insulin resistance and enhanced insulin demand in GDM may contribute to the upregulation of betatrophin levels. In addition, Natalia et al and Wang et al suggested that not only maternal but also cord blood betatrophin levels were increased in the patients with GDM [16, 18, 29]. Furthermore, the three studies mentioned above found an interesting phenomenon that betatrophin concentration in cord blood was higher than that in maternal serum, which might suggest its role in promoting β-cell proliferation during intrauterine life.…”

Section: Discussionmentioning

confidence: 99%

Circulating Betatrophin Levels and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

Kong

et al. 2017

PLoS ONE

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ObjectiveThe association between circulating betatrophin levels and gestational diabetes mellitus (GDM) is controversial. The aim of our study was to systematically review available literature linking betatrophin to GDM for a comprehensive understanding of the relationship between circulating betatrophin levels and GDM in human.MethodsPubMed, The Cochrane Library, Medline and CNKI were searched for studies published up to August 2016. Manual searches of references of the relevant original studies were conducted. Pooled estimates were measured using the fixed or random effect model. Overall effect was reported in a standard mean difference (SMD). All data were analyzed with Review Manager 5.3 and Stata 12.0.ResultsOf 25 references reviewed, 8 studies met our inclusion criteria and contributed to meta-analysis. All the studies were used to evaluate the relationship between betatrophin levels in blood and GDM. Betatrophin levels were significantly elevated in women with GDM compared with those without GDM (SMD = 1.05; 95% CI: 0.41–1.68, P = 0.001). This evidence was more consistent among women with betatrophin blood draw during the third trimester (SMD = 1.3, 95% CI: 1–1.61, P < 0.001) and for women BMI ≥ 28 kg/m2 (SMD = 1.53, 95% CI: 1.30–1.75, P < 0.001).ConclusionsThe evidences from this meta-analysis indicated that the levels of circulating betatrophin were significantly elevated among women with GDM compared with women with normal glucose tolerance, especially with BMI ≥ 28 kg/m2 and in the third trimester.

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Increased Cord Blood Betatrophin Levels in the Offspring of Mothers with Gestational Diabetes

Cited by 14 publications

References 52 publications

ANGPTL8 (betatrophin) role in diabetes and metabolic diseases

ANGPTL8 (betatrophin) role in diabetes and metabolic diseases

The Correlation Between Circulating Betatrophin and Insulin Resistance in General Population: A Meta-Analysis

Circulating Betatrophin Levels and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

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