Increased Cumulative Incidence of Prostate Malignancies in Colorectal Cancer Patients

Ozden, Nuri; Saruç, Murat; Smith, Lynette M.; Sanjeevi, Arthi; Roy, Hemant K.

doi:10.1385/ijgc:34:1:49

Cited by 6 publications

(5 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…First, an excess risk of CCa has been reported in families ascertained for PCa6,18 and conversely, an excess of PCa (RR=1.3, 95% CI 1.1–1.4) has been observed in families ascertained for CCa19. Second, a study by Ozden and colleagues (2003) found a 10.7% 10-year cumulative incidence of PCa in men with a history of CCa compared to 3.8% in men without CCa39. Third, mutations in two of the mismatch repair genes ( MLH1 , MSH3 ) that are associated with predisposition to hereditary nonpolyposis colon cancer (HNPCC), have been associated with an increased relative risk of PCa40,41.…”

Section: Discussionmentioning

confidence: 99%

Genome-wide linkage analyses of hereditary prostate cancer families with colon cancer provide further evidence for a susceptibility locus on 15q11–q14

et al. 2010

View full text Add to dashboard Cite

The search for susceptibility loci in hereditary prostate cancer (HPC) is challenging due to locus and disease heterogeneity. One approach to reduce disease heterogeneity is to stratify families based on the occurrence of multiple cancer types. This method may increase power for detecting susceptibility loci, including those with pleiotropic effects. We have completed a genome-wide SNP linkage analysis of 96 HPC families, each of which has one or more first-degree relatives with colon cancer (CCa), and further analyzed the subset of families with two or more CCa cases (n=27). When only a prostate cancer (PCa) phenotype was considered affected, we observed suggestive evidence for linkage (LOD≥1.86) at 15q14, 18q21 and 19q13 in all families, and at 1p32 and 15q11-q14 in families with two or more CCa cases. When both the PCa and CCa phenotypes were considered affected, suggestive evidence for linkage was observed at 11q25, 15q14 and 18q21 in all families, and at 1q31, 11q14, and 15q11-14 in families with two or more CCa cases. The strongest linkage signal was identified at 15q14 when both the PCa and CCa phenotypes were considered affected in families with two or more CCa cases (recessive HLOD=3.88). These results provide further support for the presence of HPC susceptibility loci on chromosomes 11q14, 15q11-q14 and 19q13 and highlight loci at 1q31, 11q, 15q14 and 18q21 as having possible pleiotropic effects. This study demonstrates the benefit of utilizing a comprehensive family cancer history to create more genetically homogenous subsets of HPC families for linkage analyses.

show abstract

Section: Discussionmentioning

confidence: 99%

Genome-wide linkage analyses of hereditary prostate cancer families with colon cancer provide further evidence for a susceptibility locus on 15q11–q14

et al. 2010

View full text Add to dashboard Cite

show abstract

“…It has been reported that there was 10.7 % risk of prostate cancer in colorectal cancer patients as compared with 3.8 % in the controls (age-matched male patients with a negative colonoscopy). [50] On the other hand, some have reported that prostate cancer survivors had a 40 % lower risk of developing a second primary cancer [16]. The other possible reason was that RT of rectal cancer could cure occult prostate cancer.…”

Section: Rectal Cancermentioning

confidence: 99%

Secondary Cancers After Radiation Therapy for Primary Prostate or Rectal Cancer

Lee

Hsieh

et al. 2015

World j. surg.

View full text Add to dashboard Cite

Literature about the risk of secondary cancer after radiation therapy (RT) of prostate and rectal cancer reveals contradictory results. We conducted a meta-analysis to examine whether the RT induces secondary rectal or prostate cancer in patients, respectively, with prostate or rectal cancer. All studies published in Medline or Pubmed up to March 3, 2015, containing RT of primary rectal or prostate cancer, and providing risk estimates of secondary prostate or rectal cancer were considered as eligible. Relative risk (RR) and standardized incidence ratios (SIR) were calculated using the random-effects model. Twenty studies met the inclusion criteria. 12 of them were from the Surveillance, Epidemiology, and End Results (SEER) database. For prostate cancer patients, pooled adjusted RRs or SIRs did not show an effect on the risk of secondary rectal cancer. However, notwithstanding the limitations of SEER-based studies, the subgroup of prostate cancer patients receiving external beam radiation therapy (EBRT) showed an increased risk of rectal cancer. For rectal cancer patients, pooled adjusted RR of prostate cancer was 1.12 (95 % CI, 0.44-2.8) and SIR was 0.40 (95 % CI, 0.29-0.55). All studies included in the SIR analysis of rectal cancer were derived from the SEER data source. Based on current evidence, RT for prostate cancer patients had no effect on rectal cancer incidence, except for patients who received EBRT therapy. However, compared with the general population, RT for rectal cancer is associated with a decreased prostate cancer risk as found in SEER-based studies.

show abstract

“…Some studies showed an increased risk of prostate cancer after colorectal cancer (15)(16)(17)(18), whereas others found no association (19)(20)(21). We found that men with rectal cancer who received radiation therapy had a decreased incidence rate of subsequent prostate cancer compared with the general population (22).…”

Section: Introductionmentioning

confidence: 99%

Association of Colorectal Cancer and Prostate Cancer and Impact of Radiation Therapy

Huo

Hetzel²,

Roy³

et al. 2009

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

To quantify the risk of prostate cancer after colorectal cancer and the risk of colorectal cancer after prostate cancer and to examine the impact of radiation therapy on subsequent cancer risk, we conducted retrospective cohort studies using data from the Surveillance, Epidemiology and End Results program from 1973 to 2005. Standardized incidence ratios (SIR) and 95% confidence intervals (95% CI) were calculated, adjusting for age, ethnicity, and calendar year. The subsequent risk of developing a prostate cancer was significantly elevated in patients diagnosed with colon cancer before age 50 years (SIR, 1.38; 95% CI, 1.18-1.60). The risk of subsequent prostate cancer was decreased for men with rectal cancer who received radiation therapy (SIR, 0.57; 95% CI, 0.52-0.63). Interestingly, this beneficial effect of radiation therapy was only observed in the prostatespecific antigen (PSA) era (1988+). In addition, the prostate cancer cases developed in the radiation therapy group tended to have higher-grade, laterstage tumors, higher PSA levels, and worse survival than those developed in the nonradiation therapy group. In the cohort of prostate cancer patients, the risk of colon cancer was elevated in patients diagnosed with prostate cancer before age 50 years (SIR, 1.51; 95% CI, 1.03-2.20). In conclusion, a diagnosis of colon or prostate cancer in men of younger ages may be an indication for screening of prostate or colon cancer, respectively. The decreased prostate cancer risk in men who received radiation therapy for rectal cancer may be related to the use of PSA for prostate cancer screening or the cure of occult prostate cancer. (Cancer Epidemiol Biomarkers Prev 2009;18(7):1979 -85)

show abstract

Increased Cumulative Incidence of Prostate Malignancies in Colorectal Cancer Patients

Abstract: This preliminary report suggests that there is an association between CRC and prostate cancer. If replicated in other populations, this may have important implications for cancer screening strategies.

Cited by 6 publications

References 19 publications

Genome-wide linkage analyses of hereditary prostate cancer families with colon cancer provide further evidence for a susceptibility locus on 15q11–q14

Genome-wide linkage analyses of hereditary prostate cancer families with colon cancer provide further evidence for a susceptibility locus on 15q11–q14

Secondary Cancers After Radiation Therapy for Primary Prostate or Rectal Cancer

Association of Colorectal Cancer and Prostate Cancer and Impact of Radiation Therapy

Contact Info

Product

Resources

About