2018
DOI: 10.1155/2018/2609767
|View full text |Cite
|
Sign up to set email alerts
|

Increased Cytokeratin 19 Fragment Levels Are Positively Correlated with Adenosine Deaminase Activity in Malignant Pleural Effusions from Adenocarcinomas

Abstract: Adenosine deaminase (ADA) and cytokeratin 19 (CK19) are known pleural biomarkers. Although ADA in humans functions mainly in the immune system, it also appears to be associated with the differentiation of epithelial cells. Keratin filaments are important structural stabilizers of epithelial cells and potent biomarkers in epithelial differentiation. This study aimed to investigate the simultaneous presence of the ADA enzyme and CK19 fragments to assess epithelial differentiation in malignant and benign pleural … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

0
9
0

Year Published

2019
2019
2024
2024

Publication Types

Select...
8

Relationship

1
7

Authors

Journals

citations
Cited by 10 publications
(9 citation statements)
references
References 27 publications
0
9
0
Order By: Relevance
“…Cytokeratin fragment 21-1 (CYFRA 21-1) is a soluble fragment of cytokeratin (CK) 19 that has been suggested to be a reliable biomarker due to its high expression in cancer fluids [15]. Several studies have demonstrated that the combination of FNAC and CYFRA 21-1 in body fluids such as lung cancer malignant pleural effusions [16,17] or axillary LN specimens of breast cancer present better diagnostic performance than FNAC alone [18].…”
Section: Introductionmentioning
confidence: 99%
“…Cytokeratin fragment 21-1 (CYFRA 21-1) is a soluble fragment of cytokeratin (CK) 19 that has been suggested to be a reliable biomarker due to its high expression in cancer fluids [15]. Several studies have demonstrated that the combination of FNAC and CYFRA 21-1 in body fluids such as lung cancer malignant pleural effusions [16,17] or axillary LN specimens of breast cancer present better diagnostic performance than FNAC alone [18].…”
Section: Introductionmentioning
confidence: 99%
“…Most studies applying highly discriminant values (55-175 ng/ml) obtained sensitivities between 24% and 70% and specificities above 95% (6, 10-13). However, in diseases such as tuberculosis, empyema and parapneumonic effusions, as well as in inflammatory processes of the surrounding tissues, high concentrations of this tumor marker can be found in the pleural fluid (11,14,15). Some biomarkers suggest a benign diagnosis: examples are adenosine deaminase (ADA) in tuberculosis and empyema, white blood cell count and the percentage of polymorphonuclear leukocytes (PN%) in empyema and complicated parapneumonic effusions, and C-reactive protein (CRP) in all three of the above conditions, and in the process of necrosis or inflammation of the surrounding tissues.…”
mentioning
confidence: 99%
“…The phenotype of hyperplasia and adenoma were differentially observed between groups ( Figure 5 b–d). Cytokeratin 19 (CK-19) was studied as a diagnostic marker of adenocarcinoma, which is known as a marker of endometrioid adenocarcinomas, pancreatic adenocarcinoma and head and neck cancer [ 19 ] ( Figure 5 d). Number of nodule was decreased about 53% in Kras LA2 ; Aldh1l1 −/− mice with phenformin treatment, while that was decreased about 9% in Kras LA2 ; Aldh1l1 −/− mice ( Figure 5 e).…”
Section: Resultsmentioning
confidence: 99%