Increased cytokines in cystic fibrosis patients’ upper airways during a new <i>P. aeruginosa</i> colonization

Jaudszus, Anke; Arnold, Christin; Hentschel, Julia; Hünniger, Kerstin; Baier, Michael; Mainz, Jochen G.

doi:10.1002/ppul.24004

Cited by 8 publications

(7 citation statements)

References 35 publications

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“…Our results show a significant increase in the inflammatory activity in the upper airways of patients with CF. The measured levels for the individual inflammatory parameters are, in principle, consistent with the results of previous studies measuring inflammatory markers in nasal lavages [26,27,[38][39][40]. Nevertheless, our values for cytokines seem to be somewhat lower compared to others.…”

Section: Inflammation and Infection Of The Upper Airwayssupporting

confidence: 91%

Increased Inflammatory Markers Detected in Nasal Lavage Correlate with Paranasal Sinus Abnormalities at MRI in Adolescent Patients with Cystic Fibrosis

et al. 2021

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Chronic rhinosinusitis (CRS) is a characteristic feature of cystic fibrosis (CF) multiorgan disease and develops early in the life of patients with CF. The study aimed to correlate the inflammatory markers and the presence of structural abnormalities detected by MRI in the paranasal sinuses of patients with CF. Methods: Nasal lavage and MRI of the paranasal sinuses was performed in a cohort of 30 CF patients (median age 14 y; range 7–20 y). Morphological abnormalities characteristic of CF were evaluated with a dedicated CRS MRI scoring system and correlated with different inflammation parameters measured in nasal lavage. Inflammation of the paranasal sinuses was positively associated with structural abnormalities in MRI. The concentration of the pro-inflammatory markers neutrophil elastase (NE) and the neutrophil elastase/alpha1-antitrypsin (NE/A1AT) complex correlated significantly with CRS-MRI sum score (p < 0.05, r = 0.416 and p < 0.05, r = 0.366, respectively). S. aureus infection was associated with the increased pro-inflammatory cytokine activity of IL-6 and IL-8, and increased levels of NE/A1AT complex in our patients (p < 0.05, respectively). CRS-MRI sum score and individual sinus MRI scores were positively associated with inflammatory activity as a sign of CRS pathology present in CF.

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Section: Inflammation and Infection Of The Upper Airwayssupporting

confidence: 91%

Increased Inflammatory Markers Detected in Nasal Lavage Correlate with Paranasal Sinus Abnormalities at MRI in Adolescent Patients with Cystic Fibrosis

et al. 2021

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“…In other studies of our group, concentrations of the proinflammatory cytokines IL‐1β, IL‐6, and IL‐8 in NL taken before new detection of P. aeruginosa in the LAW were comparable with those of patients who were free of P. aeruginosa infection. Most interestingly, at the time of P. aeruginosa detection, irrespective of whether P. aeruginosa occurred in the UAW or LAW, IL‐8 concentrations doubled, and IL‐6 concentrations tended to increase in NL 29 . Thus, early UAW assessment may be a window into LAW inflammation.…”

Section: Discussionmentioning

confidence: 98%

“…Most interestingly, at the time of P. aeruginosa detection, irrespective of whether P. aeruginosa occurred in the UAW or LAW, IL-8 concentrations doubled, and IL-6 concentrations tended to increase in NL. 29 Thus, early UAW assessment may be a window into LAW inflammation. Likewise, a longitudinal analysis with a higher number of patients is necessary to evaluate the diagnostic and prognostic utility of IgA measurement in NL and IS.…”

Section: Discussionmentioning

confidence: 99%

Antibody response against Pseudomonas aeruginosa and its relationship with immune mediators in the upper and lower airways of cystic fibrosis patients

Mauch

Hentschel

Aanæs

et al. 2020

Pediatric Pulmonology

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Background The upper airways (UAW) are a niche and a reservoir of Pseudomonas aeruginosa strains that cause chronic infection of the lower airways (LAW) in cystic fibrosis (CF). Here, we assessed the role of anti‐P. aeruginosa immunoglobulin A (IgA) and IgG antibodies in upper and lower airway infections in cystic fibrosis patients. Methods Nasal lavage fluid and induced sputum samples of 40 CF patients were microbiologically cultured. We searched for correlations between anti‐P. aeruginosa IgA and IgG levels, measured by enzyme‐linked immunosorbent assay (optical density), and unspecific immune mediators in both specimens. Results Anti‐P. aeruginosa IgA (median optical density: 0.953 vs 0.298) and IgG (0.120 vs 0.059) were significantly higher in nasal lavage than in sputum, but not significantly different between patients with and without chronic P. aeruginosa infection in UAW. Matrix metallopeptidase‐9 (MMP‐9) in nasal lavage and neutrophil elastase (NE) in sputum were predictors of IgA in nasal lavage and IgA in sputum, respectively. IgA was a predictor of myeloperoxidase (MPO) in nasal lavage. Tissue inhibitor of metalloproteinases‐1 (TIMP‐1) was a predictor of IgG in sputum. IgG, TIMP‐1, and NE in sputum were predictors of IgG in nasal lavage. Conclusion The anti‐P. aeruginosa IgA response was more prominent in CF patients' UAW, indicating a lower degree of inflammatory responses. Proteases may play a role in the anti‐P. aeruginosa humoral response in the upper and LAW, and anti‐P. aeruginosa IgG may be involved in the crosstalk between upper and lower airways in cystic fibrosis patients.

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“…The inflammatory response to airway PA infection has been described, but upper airway (UAW) inflammation has been studied less frequently. Nasal lavage (NL) cytokine concentrations were evaluated in 149 samples from 34 patients with CF, including before and at the time of de novo PA detection in UAW or lower airway (LAW) cultures, during a subsequent PA‐free period after a positive culture, and in PA‐free and chronically PA infected subjects . Before PA detection, concentrations of IL‐1β, IL‐6, and IL‐8 levels were similar to those in PA‐free patients.…”

Section: Infection Detection and Epidemiologymentioning

confidence: 99%

Cystic fibrosis year in review 2018, part 1

Savant

McColley

2019

Pediatric Pulmonology

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Increased cytokines in cystic fibrosis patients’ upper airways during a new P. aeruginosa colonization

Abstract: Monitoring cytokine dynamics in the UAW by serial NL sampling may be valuable in the early phase of PsA acquisition and, thus, increase the chance to adjust treatment options early and more specifically.

Cited by 8 publications

References 35 publications

Increased Inflammatory Markers Detected in Nasal Lavage Correlate with Paranasal Sinus Abnormalities at MRI in Adolescent Patients with Cystic Fibrosis

Increased Inflammatory Markers Detected in Nasal Lavage Correlate with Paranasal Sinus Abnormalities at MRI in Adolescent Patients with Cystic Fibrosis

Antibody response against Pseudomonas aeruginosa and its relationship with immune mediators in the upper and lower airways of cystic fibrosis patients

Cystic fibrosis year in review 2018, part 1

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