Increased Daytime Somnolence despite Normal Sleep Patterns in Patients Treated for Nonfunctioning Pituitary Macroadenoma

Klaauw, Agatha A. van der; Dekkers, Olaf M.; Pereira, Alberto M.; Kralingen, Klaas W. van; Romijn, Johannes A.

doi:10.1210/jc.2007-0944

Cited by 37 publications

(24 citation statements)

References 39 publications

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“…In addition, the daytime sleepiness scores in our patients were comparable to scores found in patients treated for other pituitary tumors or cerebral diseases such as nonfunctioning adenomas [16], craniopharyngeoma [23], hypothalamic tumors [23], subarachnoid haemorrhage [24], or traumatic brain injury [25], indicative for the relationship between cerebral disease in general and increased daytime sleepiness.…”

Section: Discussionsupporting

confidence: 78%

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Somatostatin analog treatment is associated with an increased sleep latency in patients with long-term biochemical remission of acromegaly

Klaauw

Pereira

Kralingen

et al. 2008

Growth Hormone & IGF Research

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Section: Discussionsupporting

confidence: 78%

“…Each patient was also asked to provide a healthy control person of comparable age and sex, who did not use any medication, to serve as a control group with a comparable socio-economic status. The control group was extended with controls derived from other studies in our center who were approached similarly [16].…”

Section: Protocolmentioning

confidence: 99%

Somatostatin analog treatment is associated with an increased sleep latency in patients with long-term biochemical remission of acromegaly

Klaauw

Pereira

Kralingen

et al. 2008

Growth Hormone & IGF Research

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“…[1] As more survivors live to adulthood, late effects of disease and treatment negatively impact quality of life. [2-5] Poor sleep quality, and its effects, such as daytime sleepiness, are often reported late effect of brain tumor survivors, [6-9] and may affect quality of life by decreasing participation in life events such as school, athletics, and/or social activities. A recent study by van der Klaauw et al reported that increased sleepiness (as measured by the Epworth Sleepiness Scale) in survivors of nonfunctioning pituitary adenomas was associated with 15 of 21 quality of life (QoL) subscores from four validated QoL questionnaires.…”

Section: Introductionmentioning

confidence: 99%

“…A recent study by van der Klaauw et al reported that increased sleepiness (as measured by the Epworth Sleepiness Scale) in survivors of nonfunctioning pituitary adenomas was associated with 15 of 21 quality of life (QoL) subscores from four validated QoL questionnaires. [9] Poor sleep quality and daytime sleepiness in childhood cancer survivors is also associated with neurocognitive deficits such as impaired task efficiency, diminished organization and impaired memory. [6] Clanton et al reported that the effect of sleepiness and poor sleep quality on neurocognitive outcomes is evident even after adjusting for cranial radiation therapy, steroids and antimetabolite chemotherapy, sex, and current age.…”

Section: Introductionmentioning

confidence: 99%

Sleep disturbances in adult survivors of childhood brain tumors

et al. 2012

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Purpose The aims of this study are to compare self-reported sleep quality in adult survivors of childhood brain tumors and a population-based comparison group, to identify treatment-related factors associated with sleep disturbances, and to identify the impact of post-treatment obesity and depression on sleep scores in adult survivors of childhood brain tumors. Methods Randomly selected adult survivors of childhood brain tumors (n = 78) and age, sex and zip code matched population-group members (n = 78) completed the Pittsburgh Sleep Quality Index and the Brief Symptom Inventory. Sleep quality and the effect of demographic, treatment, and post-treatment characteristics were evaluated with linear and logistic regression analyses. Results Brain tumor survivors were 2.7 (95% CI: 1.1, 6.0) times more likely than the comparison group to take greater than 30 minutes to fall asleep. Females in both groups reported worse sleep quality and impaired daytime functioning. Among survivors, post-treatment obesity was associated with daytime dysfunction. Conclusions These results agree with previous studies associating sleep, sex and obesity and identified longer sleep latency as being a problem among childhood brain tumor survivors. Further study identifying factors contributing to sleep latency, and its impact on quality of life among adult survivors of childhood brain tumors is needed.

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“…Each patient was asked to provide a control person of comparable sex and age. In addition, for every patient, one age- and sex-matched control subject was derived from a database containing results of similar questionnaires in healthy controls in our center [19]. The medical ethics committee of the Leiden University Medical Center approved the study protocol.…”

Section: Methodsmentioning

confidence: 99%

Head-and-neck paragangliomas are associated with sleep-related complaints, especially in the presence of carotid body tumors

et al. 2011

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ObjectivesThe carotid body functions as a chemoreceptor. We hypothesized that head-and-neck paragangliomas (HNP) may disturb the function of these peripheral chemoreceptors and play a role in sleep-disordered breathing.DesignThis is a case–control study.SettingThis study was conducted in a tertiary referral center.Participants and main outcome measuresWe assessed fatigue, sleep, and exercise capacity in 74 HNP patients using three questionnaires (Epworth Sleepiness Scale, St. George Respiratory Questionnaire, and a standard clinical sleep assessment questionnaire). Outcomes were compared to those of age- and sex-matched controls.Results and conclusionsActivity, disturbance of psychosocial function, and total score were worse compared to controls (15.4 ± 18.5 vs. 7.2 ± 9.9, P = 0.007; 5.3 ± 10.5 vs. 1.2 ± 2.6, P = 0.008; and 10.4 ± 12.9 vs. 5.0 ± 4.8, P = 0.006, respectively). Patients reported more daytime fatigue, concentration difficulties, and depression (51% vs. 24%, P = 0.006; 31% vs. 10%, P = 0.010; and 19% vs. 2%, P = 0.012). Waking up was reported to be less refreshing in HNP patients (53% vs. 73%, P = 0.038). Dysphonia was a predictor of symptoms, activity, disturbance of psychosocial function, and total scores. Remarkably, the presence of a carotid body tumor was an independent predictor of increased daytime sleepiness (β = 0.287, P = 0.029). In conclusion, patients with HNP have remarkable sleep-related complaints. Especially the presence of carotid body tumors appears to be associated with increased daytime somnolence.

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Increased Daytime Somnolence despite Normal Sleep Patterns in Patients Treated for Nonfunctioning Pituitary Macroadenoma

Abstract: Daytime sleepiness is increased despite normal sleep patterns in patients treated for NFMA.

Cited by 37 publications

References 39 publications

Somatostatin analog treatment is associated with an increased sleep latency in patients with long-term biochemical remission of acromegaly

Somatostatin analog treatment is associated with an increased sleep latency in patients with long-term biochemical remission of acromegaly

Sleep disturbances in adult survivors of childhood brain tumors

Head-and-neck paragangliomas are associated with sleep-related complaints, especially in the presence of carotid body tumors

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