Increased defibrillator therapies during influenza season in patients without influenza vaccines

Singh, Sheldon M.; Souza, Russell J. de; Kumareswaran, Ramanan

doi:10.1016/j.joa.2014.12.006

Cited by 4 publications

(10 citation statements)

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“…The electronic database search yielded 414 references. After removal of duplicates, screening of title and abstract and evaluation for full-text eligibility, eight studies remained for inclusion in the qualitative synthesis,9 22–28 and seven studies in the meta-analysis9 22 23 25–28 (figure 1) (online supplementary table 1). The remaining studies 24 were not included in the meta-analysis because they only reported surrogate outcomes.…”

Section: Resultsmentioning

confidence: 99%

“…Two secondary outcomes were evaluated by two studies: CV mortality26 28 and all-cause hospitalisation 9 27. Ventricular arrhythmias were evaluated in a study by Modin et al and by surrogate outcomes in a study by Singh et al which reported all implantable cardioverter defibrillator (ICD) therapies and ventricular arrhythmias/appropriate ICD shocks 24. HF-related hospitalisations and recurrent HF-related hospitalisations (HF-related hospitalisations on more than one occasion during follow-up) were only evaluated in one study 26.…”

Section: Resultsmentioning

confidence: 99%

“…Ventricular arrhythmias are of particular prognostic relevance in patients with HF, where sudden death is one of the main causes of death,1 and there were informative data from two studies: Singh et al : (surrogates of ventricular arrhythmias in a subgroup analysis) and Modin et al (ventricular arrhythmias) 24 28. In the study by Singh et al , vaccinated patients had significantly less appropriated ICD shocks (p<0.002) than non-vaccinated patients 24. In the study by Modin et al there was no association between influenza vaccination and significantly lower risk of ventricular arrhythmias 28…”

Section: Discussionmentioning

confidence: 99%

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Influenza vaccination in patients with heart failure: a systematic review and meta-analysis of observational studies

Rodrigues

David

Costa

et al. 2019

Heart

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ObjectiveDespite the progression of treatments over decades, heart failure (HF) is a disease with high morbidity, mortality and economic burden. Influenza infection is an important trigger for cardiovascular (CV) events, including HF. Influenza vaccination has been seen to reduce the risk of CV mortality in patients with coronary disease, but the effect in patients with HF is still unclear. Therefore, we conducted a systematic review to evaluate the effect of influenza vaccination in the morbimortality of patients with HF.MethodsMEDLINE, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Health Technology Assessment and PsycINFO databases (December 2018) were searched for longitudinal studies evaluating influenza vaccination compared with a non-vaccination control group in patients with HF. The risk of bias was assessed according to the ROBINS-I tool. We performed a random-effects meta-analysis to estimate the pooled HRs with 95% CIs, and heterogeneity was evaluated using the I2 statistics.ResultsSix cohort studies evaluating 179 158 patients with HF were included in the meta-analysis. Influenza vaccination was associated with a lower risk of all-cause mortality (HR=0.83; 95% CI 0.76 to 0.91; I2=75%). The effect of the influenza vaccination was not statistically significant in a pooled analysis of CV mortality (HR=0.92, 95% CI 0.73 to 1.15; 2 studies) and of all-cause hospitalisations (HR=1.01, 95% CI 0.92 to 1.11; 2 studies). The majority of outcomes in the included studies had a serious risk of bias and almost all evaluated outcomes had very low Grading of Recommendation, Assessment, Development and Evaluation (GRADE) evidence.ConclusionsInfluenza vaccination was associated with a significant decrease in all-cause mortality risk in patients with HF.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Influenza vaccination in patients with heart failure: a systematic review and meta-analysis of observational studies

Rodrigues

David

Costa

et al. 2019

Heart

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“…Increasing risk of ventricular arrhythmia during wintertime had been reported before ( 43 ). Moreover, increasing implantable cardiac defibrillator therapies was also observed during influenza season ( 44 ). However, the risk of myocardial infarction could increase even in hot weather ( 45 ).…”

Section: Discussionmentioning

confidence: 99%

Influenza Vaccination and the Risk of Ventricular Arrhythmias in Patients With Chronic Obstructive Pulmonary Disease: A Population-Based Longitudinal Study

Chen

Lin

Hao

et al. 2021

Front. Cardiovasc. Med.

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Backgrounds: Influenza vaccination could decrease the risk of major cardiac events in patients with chronic obstructive pulmonary disease (COPD). However, the effects of the vaccine on decreasing the risk of ventricular arrhythmia (VA) development in such patients remain unclear.Methods: We retrospectively analyzed the data of 18,658 patients with COPD (≥55 years old) from the National Health Insurance Research Database from January 1, 2001, to December 31, 2012. After a 1:1 propensity score matching by the year of diagnosis, we divided the patients into vaccinated and unvaccinated groups. Time-varying Cox proportional hazards regression was applied to assess the time to event hazards of influenza vaccination exposure.Results: The risk of VA occurrence was significantly lower in the vaccinated group during influenza season and all seasons [adjusted hazard ratio (aHR): 0.62, 95% CI: 0.41–0.95; aHR: 0.69, 95% CI: 0.44–1.08; and aHR: 0.65, 95% CI: 0.48–0.89, in the influenza season, non-influenza season, and all seasons, respectively]. Among patients with CHA2DS2-VASc scores (conditions and characteristics included congestive heart failure, hypertension, diabetes, stroke, vascular disease, age, and sex) of 2–3, receiving one time and two to three times of influenza vaccination were associated with lower risk of VA occurrence in all seasons (aHR: 0.28, 95% CI: 0.10–0.80; aHR: 0.27, 95% CI: 0.10–0.68, respectively). Among patients without stroke, peripheral vascular disease, and diabetes, a lower risk of VA occurrence after receiving one and two to three times vaccination was observed in all seasons. Among patients with a history of asthma and patients without a history of heart failure, ischemic heart disease, angina hypertension, or renal failure, a significantly lower risk of VA occurrence was observed after the first time of vaccination in all seasons.Conclusions: Influenza vaccination may be associated with lower risks of VA among patients with COPD aged 55–74. Further investigation is still needed to resolve this clinical question.

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“…A systematic search of online databases revealed 360 articles (PubMed = 77, EMBASE = 260, Cochrane Library = 23). After excluding duplicates and screening the titles/abstracts, 24 articles were subjected to a more detailed full-text assessment, after which seven articles with 3,169,977 patients were included in the analysis (12)(13)(14)(17)(18)(19)(20) (Figure 1). The excluded studies and the reasons for their exclusion are listed in Supplementary Table 2.…”

Section: Study Selectionmentioning

confidence: 99%

Influenza vaccination is associated with a decreased risk of atrial fibrillation: A systematic review and meta-analysis

Liu

Lin

Song

et al. 2022

Front. Cardiovasc. Med.

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BackgroundEvidence from longitudinal studies has shown that influenza infection is linked to an increased risk of arrhythmia. Therefore, we aimed to assess the role of influenza vaccination in arrhythmia prevention.Materials and methodsThe PubMed, Embase, and Cochrane Library databases were searched to identify studies that investigated the potential effects of the influenza vaccine on arrhythmia risk published until October 25th, 2021. The study was registered with PROSPERO (CRD42022300815).ResultsOne RCT with 2,532 patients and six observational studies with 3,167,445 patients were included. One RCT demonstrated a non-significant benefit of the influenza vaccine against arrhythmias [odds ratio (OR) = 0.43, 95% confidence interval (CI): 0.11–1.64; P = 0.20] in patients after myocardial infarction or those with high-risk stable coronary heart disease. A meta-analysis based on observational studies showed that vaccination was associated with a significantly lower risk of arrhythmia (OR: 0.82, 95% CI: 0.70–0.97; P = 0.02; I2 = 76%). Additionally, subgroup analysis showed a decreased risk of atrial fibrillation (AF) (OR: 0.94, 95% CI: 0.90–0.98; P = 0.006; I2 = 0%) and a non-significant but positive trend concerning ventricular arrhythmias (VAs) (OR: 0.68, 95% CI: 0.42–1.11; P = 0.12; I2 = 85%) after influenza vaccination.ConclusionBased on the current evidence, influenza vaccination may be associated with a reduced risk of arrhythmia, especially AF. Influenza vaccination may be an effective tool for the prevention of arrhythmias. The effect of influenza vaccination on the risk of VAs and arrhythmias in patients at low risk for cardiovascular diseases should be further studied.Systematic review registration[https://www.crd.york.ac.uk/PROSPERO/], identifier [CRD42022300815].

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Increased defibrillator therapies during influenza season in patients without influenza vaccines

Cited by 4 publications

References 14 publications

Influenza vaccination in patients with heart failure: a systematic review and meta-analysis of observational studies

Influenza vaccination in patients with heart failure: a systematic review and meta-analysis of observational studies

Influenza Vaccination and the Risk of Ventricular Arrhythmias in Patients With Chronic Obstructive Pulmonary Disease: A Population-Based Longitudinal Study

Influenza vaccination is associated with a decreased risk of atrial fibrillation: A systematic review and meta-analysis

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