Increased Density of &lt;b&gt;&lt;i&gt;Demodex folliculorum&lt;/i&gt;&lt;/b&gt; Mites in Pregnancies with Gestational Diabetes

Kurt, Raziye Keskin; Kaya, Özlem Aycan; Karateke, Atilla; Şilfeler, Dilek Benk; Karapınar, Oya Soylu; Akkoca, Ayşe Neslin; Hakverdi, Ali Ulvi

doi:10.1159/000363244

Cited by 29 publications

(23 citation statements)

References 20 publications

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“…The delicate host/ Demodex equilibrium may be tipped in favor of mite proliferation by various factors, including immunosuppression [ 61 – 88 ], diabetes [ 89 – 92 ]), vasodilatory-related factors [ 8 , 10 , 25 , 27 , 31 , 57 , 93 – 97 ], and/or sebaceous hyperplasia [ 8 , 10 , 51 , 98 ]. Initially, overproliferation of the mite is not clinically visible, giving rise to what could be called subclinical demodicosis, which can be observed in many skin conditions (including apparently healthy skin and any facial dermatosis), but is commonly encountered in ETR [ 97 ] (Fig.…”

Section: Demodex and Demodicosismentioning

confidence: 99%

The Pathogenic Role of Demodex Mites in Rosacea: A Potential Therapeutic Target Already in Erythematotelangiectatic Rosacea?

Forton¹

2020

Dermatol Ther (Heidelb)

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Rosacea is an inflammatory continuum, with all characteristics being already present from the onset of the disease, even if not clinically visible. Demodex proliferation also appears to be a continuum process in rosacea, and high Demodex density is beginning to be accepted as an important trigger of the inflammatory cascade and as a marker of rosacea: moreover, papulopustules of rosacea can be treated using acaricides. Immunological studies are providing new hypotheses according to which Demodex may induce tolerogenic dendritic cells and collaborate with VEGF to induce T cell exhaustion favoring its own proliferation. This proliferation may not be clinically visible initially. The interactions among VEGF, Demodex, and immunity need to be explored, and the nosology of rosacea definitions adapted accordingly. The effectiveness of treating any patient who only has visible vascular symptoms with an acaricidal cream needs to be confirmed in prospective controlled clinical trials with long-term follow-up, but it is already important to detect patients with pityriasis folliculorum among those with only vascular symptoms of rosacea in order to treat at least these patients with an acaricidal cream. DIGITAL FEATURES This article is published with digital features to facilitate understanding of the article. You can access the digital features on the article's associated Figshare page. To view digital features for this article go to

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Section: Demodex and Demodicosismentioning

confidence: 99%

The Pathogenic Role of Demodex Mites in Rosacea: A Potential Therapeutic Target Already in Erythematotelangiectatic Rosacea?

Forton¹

2020

Dermatol Ther (Heidelb)

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“…Another study concludes that there was an increased Demodex density in gestational diabetes patients. This study stated that the reason for this result might be insufficient glucose regulation 30 …”

Section: Discussionmentioning

confidence: 80%

Association between Demodex folliculorum and Metabolic Syndrome

Özer¹,

Akyürek

Durmaz³

2020

J of Cosmetic Dermatology

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Background Demodex folliculorum mite infestation is associated with many diseases such as rosacea, pityriasis found with acne vulgaris, and blepharitis. Aim In this research, the aim of this study was to investigate an association between patients who have metabolic syndrome and presence of Demodex folliculorum. Patients/Methods This research was planned prospectively as a case‐control study. Fifty cases who have metabolic syndrome and 50 control subjects in good health were included. Metabolic syndrome was diagnosed according to the NCEP Adult Treatment Panel III criteria. Standard superficial skin biopsy was performed for the presence of Demodex folliculorum mite infestation. Results It was detected that number of Demodex affected from the glucose level and each increase in glucose level cause an increase on Demodex as 0.190 (P = .00, t = 4.746, B = 0.190, r = 0.57, Durbin‐Watson = 1.801, confidence interval = 0.110 to 0.271 (for glucose)). Conclusion In this study, the presence of Demodex folliculorum was found to be higher in the cases who have metabolic syndrome compared to the healthy group. These results show that in cases with metabolic syndrome, high blood sugar levels make them more susceptible to infestation of Demodex folliculorum.

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“…In a study that evaluated 42 patients with type 2 DM, DF was observed at a higher rate in the cases with diabetes (54.8%) (13). In a study of patients with gestational diabetes, the prevalence of DF was statistically significantly higher in the patients with gestational diabetes than in the normal pregnancies (24.2% vs 3.3%) (14). In our study, DF positivity was determined as 43.7% in DM patients.…”

Section: Discussionmentioning

confidence: 95%

The Incidence of Demodex folliculorum in the Combination of Allergic Rhinitis and Diabetes Mellitus

Arlı

Özsan

Gürkan

et al. 2019

IJPA

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Background: Demodex mites are permanent ectoparasites of human pilosebaceous unit. They mainly infect skin of the face and scalp. Many studies have shown higher density of the ectoparasites in diseased inflammatory skin than in normal skin. The aim of this study was to determine the frequency of Demodex folliculorum (DF) in treatment-resistant patients with the combination of allergic rhinitis (AR) and diabetes mellitus (DM). Method: This study was conducted in 2014-2017. It included 92 patients aged 18-70 years who presented at the Ear, Nose and Throat (ENT) and Endocrinology Polyclinics of Mustafa Kemal University Medical Faculty Hospital, Turkey. An age and gender matched control group was formed of 30 healthy individuals. To determine the presence of DF, a few eyelashes were taken from eyelids in both groups. Then samples were examined under a light microscope. Results: DF positivity was determined in 44 (47.8%) of the 92 patients and in 1 (3.3%) of the 30 control group subjects. In the patient group, DF positivity was evaluated as present in 14 (43.7%) of the DM patients, in 12 (40%) of the AR patients and in 18 (60%) of the AR+DM patients. Statistically significant DF incidence was found in all three patient groups compared to the control group (P=0.001). The incidence in AR + DM group was not different from other patient groups. Conclusion: DM, AR, advanced age and obesity had prepared the environment for Demodex infestations. This issue should be considered especially in treatment of patients with AR+DM.

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Increased Density of <b><i>Demodex folliculorum</i></b> Mites in Pregnancies with Gestational Diabetes

Cited by 29 publications

References 20 publications

The Pathogenic Role of Demodex Mites in Rosacea: A Potential Therapeutic Target Already in Erythematotelangiectatic Rosacea?

The Pathogenic Role of Demodex Mites in Rosacea: A Potential Therapeutic Target Already in Erythematotelangiectatic Rosacea?

Association between Demodex folliculorum and Metabolic Syndrome

The Incidence of Demodex folliculorum in the Combination of Allergic Rhinitis and Diabetes Mellitus

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