Increased Dependence of Action Selection on Recent Motor History in Parkinson's Disease

Helmich, Rick C.; Aarts, Esther; Lange, Floris P. de; Bloem, Bastiaan R.; Toni, Ivan

doi:10.1523/jneurosci.0704-09.2009

Cited by 72 publications

(69 citation statements)

References 61 publications

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“…The identified areas would likewise belong to components of the salience network considered responsible for switching between activation and deactivation of large-scale brain networks so as to support different general functional states of the brain (Sridharan et al, 2008). The involvement of the putamen and the ventral striatopallidum corroborates the view that basal ganglia and frontostriatal circuits are of importance for switching between task sets rather than resolving control issues within task sets or particular movements (Cools et al, 1984;Mink, 1996;Redgrave et al, 1999;Rushworth et al, 2002;Helmich et al, 2009).…”

Section: Task Set Switchingsupporting

confidence: 57%

Selection of Prime Actor in Humans during Bimanual Object Manipulation

Theorin¹,

Johansson²

2010

J. Neurosci.

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In bimanual object manipulation tasks, people flexibly assign one hand as a prime actor while the other assists. Little is known, however, about the neural mechanisms deciding the role assignment. We addressed this issue in a task in which participants moved a cursor to hit targets on a screen by applying precisely coupled symmetrical opposing linear and twist forces on a tool held freely between the hands. In trials presented in an unpredictable order, the action of either the left or the right hand was spatially congruent with the cursor movements, which automatically rendered the left or right hand the dominant actor, respectively. Functional magnetic resonance imaging indicated that the hand-selection process engaged prefrontal cortical areas belonging to an executive control network presumed critical for judgment and decision-making and to a salience network attributed to evaluation of utility of actions. Task initiation, which involved switching between task sets, had a superordinate role with reference to hand selection. Behavioral and brain imaging data indicated that participants initially expressed two competing action representations, matching either mapping rule, before selecting the appropriate one based on the consequences of the initial manual actions. We conclude that implicit processes engaging the prefrontal cortex reconcile selections among action representations that compete for the establishment of a dominant actor in bimanual object manipulation tasks. The representation selected is the one that optimizes performance by relying on the superior capacity of the brain to process spatial congruent, as opposed to noncongruent, mappings between manual actions and desired movement goals.

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Section: Task Set Switchingsupporting

confidence: 57%

Selection of Prime Actor in Humans during Bimanual Object Manipulation

Theorin¹,

Johansson²

2010

J. Neurosci.

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“…Such task-related FC is not as commonly studied as resting-state FC, though several groups have published measures of effective connectivity (EC) during a task (Helmich et al, 2009;Palmer et al, 2009Palmer et al, , 2010Wu et al, 2010Wu et al, , 2011b. EC differs from FC in that it is measured during a traditional fMRI scan (i.e., with alternating task blocks), rather than in what we refer to as an fcMRI scan, in which the subject is in a constant state throughout the entire scan.…”

Section: Discussionmentioning

confidence: 99%

Exercise Therapy for Parkinson's Disease: Pedaling Rate Is Related to Changes in Motor Connectivity

et al. 2016

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Forced-rate lower-extremity exercise has recently emerged as a potential safe and low-cost therapy for Parkinson's disease (PD). The efficacy is believed to be dependent on pedaling rate, with rates above the subjects' voluntary exercise rates being most beneficial. In this study, we use functional connectivity magnetic resonance imaging (MRI) to further elucidate the mechanism underlying this effect. Twenty-seven PD patients were randomized to complete 8 weeks of forced-rate exercise (FE) or voluntary-rate exercise (VE). Exercise was delivered using a specialized stationary bicycle, which can augment patients' voluntary exercise rates. The FE group received assistance from the cycle. Imaging was conducted at baseline, end of therapy, and after 4 weeks of follow-up. Functional connectivity (FC) was determined via seed-based correlation analysis, using activationbased seeds in the primary motor cortex (M1). The change in FC after exercise was compared using linear correlation with pedaling rate. Results of the correlation analysis showed a strong positive correlation between pedaling rate and change in FC from the most affected M1 to the ipsilateral thalamus. This effect persisted after 4 weeks of follow-up. These results indicate that a plausible mechanism for the therapeutic efficacy of high-rate exercise in PD is that it improves thalamo-cortical connectivity.

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“…We characterize functional and structural markers of cortical changes associated with the LRRK2 G2019S mutation, comparing asymptomatic LRRK2 carriers with non-mutation carriers. We assess a core deficit of Parkinson's disease: the internal selection of motor representations (Brown and Marsden, 1988;Helmich et al, 2009). To identify these markers, we use a validated motor imagery task in which subjects are asked to make laterality judgements (left or right) of hand pictures (de Lange et al, 2005;Helmich et al, 2009) while measuring behavioural performance (reaction times) and cerebral activity (using functional MRI).…”

Section: Introductionmentioning

confidence: 99%

“…We assess a core deficit of Parkinson's disease: the internal selection of motor representations (Brown and Marsden, 1988;Helmich et al, 2009). To identify these markers, we use a validated motor imagery task in which subjects are asked to make laterality judgements (left or right) of hand pictures (de Lange et al, 2005;Helmich et al, 2009) while measuring behavioural performance (reaction times) and cerebral activity (using functional MRI). Previous studies have shown that subjects solve this task by mentally moving their own hand from its current position into the stimulus orientation for comparison (Parsons, 1987;de Lange et al, 2008a).…”

Section: Introductionmentioning

confidence: 99%

Cerebral pathological and compensatory mechanisms in the premotor phase of leucine-rich repeat kinase 2 parkinsonism

Nuenen

Helmich

Ferraye

et al. 2012

Brain

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Compensatory cerebral mechanisms can delay motor symptom onset in Parkinson's disease. We aim to characterize these compensatory mechanisms and early disease-related changes by quantifying movement-related cerebral function in subjects at significantly increased risk of developing Parkinson's disease, namely carriers of a leucine-rich repeat kinase 2-G2019S mutation associated with dominantly inherited parkinsonism. Functional magnetic resonance imaging was used to examine cerebral activity evoked during internal selection of motor representations, a core motor deficit in clinically overt Parkinson's disease. Thirty-nine healthy first-degree relatives of Ashkenazi Jewish patients with Parkinson's disease, who carry the leucinerich repeat kinase 2-G2019S mutation, participated in this study. Twenty-one carriers of the leucine-rich repeat kinase 2-G2019S mutation and 18 non-carriers of this mutation were engaged in a motor imagery task (laterality judgements of left or right hands) known to be sensitive to motor control parameters. Behavioural performance of both groups was matched. Mutation carriers and non-carriers were equally sensitive to the extent and biomechanical constraints of the imagined movements in relation to the current posture of the participants' hands. Cerebral activity differed between groups, such that leucine-rich repeat kinase 2-G2019S carriers had reduced imagery-related activity in the right caudate nucleus and increased activity in the right dorsal premotor cortex. More severe striatal impairment was associated with stronger effective connectivity between the right dorsal premotor cortex and the right extrastriate body area. These findings suggest that altered movement-related activity in the caudate nuclei of leucine-rich repeat kinase 2-G2019S carriers might remain behaviourally latent by virtue of cortical

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Increased Dependence of Action Selection on Recent Motor History in Parkinson's Disease

Cited by 72 publications

References 61 publications

Selection of Prime Actor in Humans during Bimanual Object Manipulation

Selection of Prime Actor in Humans during Bimanual Object Manipulation

Exercise Therapy for Parkinson's Disease: Pedaling Rate Is Related to Changes in Motor Connectivity

Cerebral pathological and compensatory mechanisms in the premotor phase of leucine-rich repeat kinase 2 parkinsonism

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