Increased Distraction Rates Influence Precursor Tissue Composition Without Affecting Bone Regeneration

Richards, Mark; Kozloff, Kenneth M.; Goulet, James A.; Goldstein, Steven A.

doi:10.1359/jbmr.2000.15.5.982

Cited by 26 publications

(2 citation statements)

References 42 publications

(103 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results highlight the natural bone formation process observed during the consolidation phase in DO. As discussed earlier, it has been shown that mineralization starts in areas close to the native cortices and goes through the center of the distracted callus [5,[53][54][55]. Thus, our results showed that the periosteal and endosteal callus close to the native cortices were at a more advanced stage than the rest of the callus.…”

Section: Spatial Variation Of the Mineralized Tissuessupporting

confidence: 77%

Mechanical Characterization at the Microscale of Mineralized Bone Callus after Bone Lengthening

2022

View full text Add to dashboard Cite

Distraction osteogenesis (DO) involves several processes to form an organized distracted callus. While bone regeneration during DO has been widely described, no study has yet focused on the evolution profile of mechanical properties of mineralized tissues in the distracted callus. The aim of this study was therefore to measure the elastic modulus and hardness of calcified cartilage and trabecular and cortical bone within the distracted callus during the consolidation phase. We used a microindentation assay to measure the mechanical properties of periosteal and endosteal calluses; each was subdivided into two regions. Histological sections were used to localize the tissues. The results revealed that the mechanical properties of calcified cartilage did not evolve over time. However, trabecular bone showed temporal variation. For elastic modulus, in three out of four regions, a similar evolution profile was observed with an increase and decrease over time. Concerning hardness, this evolves differently depending on the location in the distracted callus. We also observed spatial changes in between regions. A first duality was apparent between regions close to the native cortices and the central area, while latter differences were seen between periosteal and endosteal calluses. Data showed a heterogeneity of mechanical properties in the distracted callus with a specific mineralization profile.

show abstract

Section: Spatial Variation Of the Mineralized Tissuessupporting

confidence: 77%

Mechanical Characterization at the Microscale of Mineralized Bone Callus after Bone Lengthening

2022

View full text Add to dashboard Cite

show abstract

“…Under stimuli with the same strain magnitude, higher strain cycle will cause a more significant adaptive response [29, 30]. Similarly, signals at 15 to 60 Hz, in comparison to signals at about 1 Hz, can stimulate more bone growth [31, 32] (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Mechanotransduction in Musculoskeletal Tissue Regeneration: Effects of Fluid Flow, Loading, and Cellular-Molecular Pathways

Qin

2014

BioMed Research International

View full text Add to dashboard Cite

While mechanotransductive signal is proven essential for tissue regeneration, it is critical to determine specific cellular responses to such mechanical signals and the underlying mechanism. Dynamic fluid flow induced by mechanical loading has been shown to have the potential to regulate bone adaptation and mitigate bone loss. Mechanotransduction pathways are of great interests in elucidating how mechanical signals produce such observed effects, including reduced bone loss, increased bone formation, and osteogenic cell differentiation. The objective of this review is to develop a molecular understanding of the mechanotransduction processes in tissue regeneration, which may provide new insights into bone physiology. We discussed the potential for mechanical loading to induce dynamic bone fluid flow, regulation of bone adaptation, and optimization of stimulation parameters in various loading regimens. The potential for mechanical loading to regulate microcirculation is also discussed. Particularly, attention is allotted to the potential cellular and molecular pathways in response to loading, including osteocytes associated with Wnt signaling, elevation of marrow stem cells, and suppression of adipotic cells, as well as the roles of LRP5 and microRNA. These data and discussions highlight the complex yet highly coordinated process of mechanotransduction in bone tissue regeneration.

show abstract

Bone regeneration during distraction osteogenesis

2009

View full text Add to dashboard Cite

Bone has the capacity to regenerate in response to injury. During distraction osteogenesis, the renewal of bone is enhanced by gradual stretching of the soft connective tissues in the gap area between two separated bone segments. This procedure has received much clinical attention as a way to correct congenital growth retardation of bone tissue or to generate bone to fill skeletal defects. The process of bone regeneration involves a complex system of biological changes whereby mechanical stress is converted into a cascade of signals that activate cellular behavior resulting in (enhanced) formation of bone. Over the last decade, significant progress has been made in understanding the bone regeneration process during distraction osteogenesis. The mechanical and biological factors that are important for the success of the distraction treatment have been partially characterized and are discussed in this review.

show abstract

Increased Distraction Rates Influence Precursor Tissue Composition Without Affecting Bone Regeneration

Cited by 26 publications

References 42 publications

Mechanical Characterization at the Microscale of Mineralized Bone Callus after Bone Lengthening

Mechanical Characterization at the Microscale of Mineralized Bone Callus after Bone Lengthening

Mechanotransduction in Musculoskeletal Tissue Regeneration: Effects of Fluid Flow, Loading, and Cellular-Molecular Pathways

Bone regeneration during distraction osteogenesis

Contact Info

Product

Resources

About