Increased DNA damage and oxidative stress in patients with rheumatoid arthritis

Altindag, Ozlem; Karakoç, Mehmet; Koçyiğit, Abdürrahim; Çelik, Hakim; Soran, Neslihan

doi:10.1016/j.clinbiochem.2006.10.006

Cited by 117 publications

(96 citation statements)

References 25 publications

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“…There are publications reporting changes in the proand antioxidative equilibrium parameters in depression, as well as in the diseases which accompany depression (Altindag et al, 2007;Bilici et al, 2001;Khanzode et al, 2003;Kotur-Stevuljevic et al, 2007;Larrea et al, 1998;Michel et al, 2007;Nadeem et al, 2005;Sarandol et al, 2007). Indirect evidence for the effect of oxidative stress on the structure of cell membrane lipids are presented by Peet et al (1998).…”

Section: Introductionmentioning

confidence: 94%

Oxidative stress parameters after combined fluoxetine and acetylsalicylic acid therapy in depressive patients

Gałecki

Szemraj

Bieńkiewicz

et al. 2009

Human Psychopharmacology

120

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The obtained results indicate a significant decrease in the activity of SOD1, CAT and GSHP-x, as well as in MDA concentration after the combined therapy. Also a significant TAS increase was observed after the combined therapy. The study demonstrated that combined therapy with fluoxetine and ASA is characterized by the same efficacy and clinical safety as fluoxetine monotherapy, resulting additionally in improvement of oxidative stress parameters in the patients treated for depression.

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Section: Introductionmentioning

confidence: 94%

Oxidative stress parameters after combined fluoxetine and acetylsalicylic acid therapy in depressive patients

Gałecki

Szemraj

Bieńkiewicz

et al. 2009

Human Psychopharmacology

120

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“…Oxidative stress has been implicated in the promotion of inflammation due to the formation of peroxynitrite and downstream activation of transcriptional factors such as NF-B [7,8]. Critically, allantoin has been reported as a sensitive marker of oxidative stress [9,10].…”

Section: Introductionmentioning

confidence: 99%

Allantoin as A Biomarker of Inflammation in an Inflammatory Bowel Disease Mouse Model: NMR Analysis of Urine

Dryland¹,

Love²,

Walker³

et al. 2008

Open Bioact Compd J

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Crohn's disease (CD) is an Inflammatory Bowel Disease (IBD) that is characterised by destructive inflammation of the intestinal wall. Current methods for determining inflammation of the bowel are costly, time consuming and can cause discomfort to the patients. In order to address these problems, biomarker analysis of more accessible tissues is receiving increasing attention. Oxidative stress has been implicated in the promotion of inflammation. Allantoin has recently been reported as a biomarker for oxidative stress in human serum and urine. This paper investigates allantoin as a biomarker of inflammation in a mouse model of CD. Proton nuclear magnetic resonance ( 1 H NMR) spectroscopy was used to analyse allantoin in urine from the mdr1a -/-mouse which is a model of CD. The data show that the levels of allantoin are strongly correlated with histological injury scores of mouse colonic tissue samples. Allantoin appears to be a useful biomarker of gut inflammation, involving oxidative stress, in a mouse model of CD and may be a potential biomarker in human CD studies.

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“…Altindag et al [10] showed that DNA damage in peripheric blood lymphocytes in patients with rheumatoid arthritis was related to severity of the disease. Similarly, we showed that the more extensive the magnitude of dissection associated with the procedure, the greater the concentration and the higher the level of plasma DNA observed.…”

Section: Discussionmentioning

confidence: 99%

“…The pathophysiological mechanisms associated with these elevations include cell death, both physiologic such as with aging [1] and pathologic such as after stroke [2] , pulmonary emboli [3,4] , tissue injury as a result of trauma [5][6][7] , extensive exercise [8] , and multisystem organ failure [9] . Other mechanisms include inflammatory processes that occur in patients with rheumatoid arthritis [10] , lupus erythematosus [11] and polyarteritis nodosa [12] . Plasma DNA has been shown to be elevated in a number of different malignancies such as breast [13] , lung [14] , liver [15] and pancreas [16] , where it has also been used as a molecular marker.…”

Section: Introductionmentioning

confidence: 99%

Plasma DNA: A Molecular Marker of Surgical Insult and Postoperative Recovery in Esophageal Cancer

Banki¹,

Mason²,

Hagen³

et al. 2008

Eur Surg Res

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Aim: To assess plasma DNA changes intraoperatively, to relate plasma DNA to the magnitude of the surgical insult and to monitor the changes during the postoperative recovery period. Material and Method: Prospective study of 35 patients with esophageal cancer who had esophagectomy of different magnitudes: 19 esophagectomy without thoracotomy and 16 esophagectomy with thoracotomy. The plasma DNA was measured prior to surgery, throughout the course of the operation on four different intervals, and on postoperative days 1, 3, 5, and 7. Results: A significant difference was seen in the median plasma DNA intraoperatively between the two groups: esophagectomy without thoracotomy, 507 ng/ml/min (range 211–2,708), esophagectomy with thoracotomy, median 1,098 ng/ml/min (range 295–22,284; p = 0.014). Postoperative complications were identified in 6 patients who demonstrated a significant elevation in plasma DNA on postoperative days 5 and 7. Conclusion: Plasma DNA increases during surgery as a result of cell damage and the rise correlates with the magnitude of surgery. The descent of plasma DNA postoperatively correlates with surgical recovery. Elevation of the plasma DNA during the postoperative period correlates with postoperative complications. Plasma DNA is an objective molecular marker of surgical insult and can be used to monitor postoperative recovery after esophagectomy.

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Increased DNA damage and oxidative stress in patients with rheumatoid arthritis

Cited by 117 publications

References 25 publications

Oxidative stress parameters after combined fluoxetine and acetylsalicylic acid therapy in depressive patients

Oxidative stress parameters after combined fluoxetine and acetylsalicylic acid therapy in depressive patients

Allantoin as A Biomarker of Inflammation in an Inflammatory Bowel Disease Mouse Model: NMR Analysis of Urine

Plasma DNA: A Molecular Marker of Surgical Insult and Postoperative Recovery in Esophageal Cancer

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