Increased EEG Current-Source Density in the High Beta Frequency Band Induced by Levetiracetam Adjunctive Therapy in Refractory Partial Epilepsy

Park, Sung-Pa; Kwon, Oh-Young

doi:10.3988/jcn.2009.5.4.178

Cited by 16 publications

(15 citation statements)

References 40 publications

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“…In our previous study, the CSD of the high beta frequency band increased in the bilateral anterior cingulate gyri, left parahippocampal gyrus, and a small area of the right anterior parahippocampal gyrus after a 24-week levetiracetam (LEV) trial in patients with refractory partial epilepsy. In the previous study, verbal memory and executive function improved 26. In contrast, the CSD of the high beta frequency band decreased in the superior frontal, middle frontal, anterior cingulate, precentral, postcentral, and inferior parietal gyri of the left hemisphere, and the middle frontal, inferior frontal and anterior cingulate gyri of the right hemisphere after the 24-week ZNS trial in the present study.…”

Section: Discussioncontrasting

confidence: 50%

Zonisamide Decreases Current-Source Density of High Beta Frequency of Electroencephalogram

Kwon¹,

Park²

2013

J Epilepsy Res

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Background and Purpose:The purpose of this study was to investigate changes in brain current-source density (CSD) of the high frequency band (22–30 Hz) induced by zonisamide (ZNS) in patients with newly diagnosed epilepsy and to correlate with the cognitive performances.Methods:We conducted a 24-week, open-labeled, prospective study in 19 patients. Eelectroencephalography (EEG) and neuropsychological tests (NPs) were conducted at baseline and 24 weeks after starting the medication. Six patients were excluded due to artifacts in EEG. One patient did not attend follow-up studies. Twelve patients who completed follow-up EEG and NPs were included. We used low-resolution brain electromagnetic tomography to determine CSD, and we obtained statistical nonparametric maps for the high beta frequency band (22–30 Hz) between pretreatment EEGs and post-treatment EEGs.Results:The CSD in the 22–30 Hz band decreased in the superior frontal, middle frontal, anterior cingulate, precentral, postcentral, and inferior parietal gyri of the left hemisphere, and the middle frontal, inferior frontal and anterior cingulate gyri of the right hemisphere. Among the NPs items, the performance of verbal fluency was significantly impaired after the 24-week ZNS trial.Conclusions:The CSD changes suggest ZNS may diminish the activity of cerebral networks related to verbal fluency.

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Section: Discussioncontrasting

confidence: 50%

Zonisamide Decreases Current-Source Density of High Beta Frequency of Electroencephalogram

Kwon¹,

Park²

2013

J Epilepsy Res

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“…19 – 21 ) Other studies have used similar neuropsychological tests to measure such executive functions. 22 , 23 ) Software developed in our own laboratory (DELPHI 5.0) was used to analyze the reaction time. Participants had to choose a square (25% of total shapes) among various circles, identifying the reaction time.…”

Section: Methodsmentioning

confidence: 99%

The Influence of Levetiracetam in Cognitive Performance in Healthy Individuals: Neuropsychological, Behavioral and Electrophysiological Approach

Magalhães

Gongora

Vicente

et al. 2015

Clin Psychopharmacol Neurosci

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ObjectiveThe present study sought to analyze the influence of Levetiracetam (LEV) in cognitive performance by identifying the changes produced by LEV in reaction time, in neuropsychological assessment of attention and memory and in absolute theta power in frontal activity.MethodsTwelve healthy subjects (5 men and 7 women; mean age, 30.08 years, standard deviation, 4.71) were recruited for this study. The neuropsychological tests: Trail Making Test (A and B), Digit Span (direct and indirect numerical orders/working memory); Stroop test (inhibitory control of attention); Tower of London (planning and decision-making) and a quantitative electroencephalography were applied in 2 different days after and before the participants ingested the capsule of placebo or 500 mg LEV.ResultsA two-way-ANOVA was implemented to observe the interaction between conditions (placebo or LEV 500 mg) and moments (pre- and post-ingestion of LEV or placebo). The data were analyzed by the SPSS statistical package (p<0.05). For the neuropsychological parameter, the Trail Making Test (A) was the only test that showed significant difference for condition in the task execution time (p=0.026). Regarding the reaction time in the behavioral parameter, an interaction between both factors (p=0.034) was identified through a two-way-ANOVA (condition versus moment). Electrophysiological measures showed a significant interaction for electrodes: F7, F3, and FZ.ConclusionThe findings showed that LEV promotes an important cognitive enhancement in the executive functions.

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“…One recent report stated that LEV therapy increases the 22–30 Hz band of EEG background activity in the bilateral anterior cingulate and left parahippocampal gyri of patients with refractory partial epilepsy, and that this change is associated with improvements in verbal memory and executive function. 16 LEV has also been shown to decrease delta and theta power in the frontopolar and anterior areas, increase alpha2 in diffuse areas, and increase beta2 in the left temporal area. 17 …”

Section: Discussionmentioning

confidence: 94%

“… 14 LEV does not negatively influence cognitive function and may even improve it. 15 EEG studies have reported that LEV has a positive effect on cerebral neuronal activity and cognitive function; 16 , 17 however, these studies investigated only the long-term effects of LEV, and changes in cerebral glucose metabolism were not assessed.…”

Section: Introductionmentioning

confidence: 99%

Changes in background electroencephalography and regional cerebral glucose metabolism in focal epilepsy patients after 1-month administration of levetiracetam

Kim¹,

Lim²,

Kim³

et al. 2015

NDT

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The antiseizure efficacy and safety of levetiracetam (LEV) is well documented; however, few clinical studies have investigated the predictability of patient responsiveness to LEV, especially when the drug is first administered. The aim of this study was to ascertain the utility of clinical, electrophysiological, and neuroimaging parameters for assessing the early response to LEV treatment in focal epilepsy patients. Twelve confirmed focal epilepsy patients were included who had never taken LEV before. At baseline and 1 month after LEV administration, all subjects underwent 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) and electroencephalography (EEG), and completed the Quality of Life in Epilepsy questionnaire (QOLIE-31). Participants were divided by drug response: good versus poor. The good response group (seven subjects) was defined by a >50% decrease in seizure frequency compared to baseline (3 months before LEV intake). The other five participants with a <50% decrease in seizure frequency were placed into the poor response group. We compared the differential changes in brain glucose metabolism on FDG-PET, power spectrum on the EEG, and QOLIE-31 results between the two groups after a 1-month LEV trial. In the good response group, it was possible to identify brain regions with increased glucose metabolism, including the bilateral caudate nuclei and both frontal and left parietal regions (uncorrected P<0.005). In the poor response group, FDG-PET did not reveal any areas with significantly increased glucose metabolism. In the good response group, spectral EEG analysis revealed decreased delta power (1–3 Hz, P<0.05) in the parietal region and increased beta1 power (13–19 Hz, P<0.05) in the frontal region, whereas no significant changes were observed in the poor response group. There were no significant changes on the QOLIE-31 in either group after a 1-month LEV trial. Our results suggest that LEV-induced glucose metabolism and EEG spectral changes may be indicative of initial drug responsiveness as early as 1 month following treatment initiation. These parameters may be useful prognostic markers of antiseizure effects caused by LEV medication or may indicate an epiphenomenon of LEV-induced changes in glucose metabolism and EEG frequency. Further studies with larger sample sizes are warranted.

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Increased EEG Current-Source Density in the High Beta Frequency Band Induced by Levetiracetam Adjunctive Therapy in Refractory Partial Epilepsy

Cited by 16 publications

References 40 publications

Zonisamide Decreases Current-Source Density of High Beta Frequency of Electroencephalogram

Zonisamide Decreases Current-Source Density of High Beta Frequency of Electroencephalogram

The Influence of Levetiracetam in Cognitive Performance in Healthy Individuals: Neuropsychological, Behavioral and Electrophysiological Approach

Changes in background electroencephalography and regional cerebral glucose metabolism in focal epilepsy patients after 1-month administration of levetiracetam

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