Increased Egg Production by Active Immunization against Vasoactive Intestinal Peptide in the Turkey (Meleagris gallopavo)1

Halawani, M. E. El; Silsby, J.L.; Rozenboim, Israel; Pitts, Gilbert R.

doi:10.1095/biolreprod52.1.179

Cited by 70 publications

(23 citation statements)

References 26 publications

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“…Similarly, in this study, the same sites including the site I31391359D of the NPY gene and the A19960831G of the GnRHR gene were selected to analyze their effects on EN300, and the results were compatible with findings of Dunn et al (2004). Previous reports confirmed that active immunization with VIP could increase egg production in turkeys (El Halawani et al, 1995;Caldwell et al, 1999). Also, another study discovered that an AGG indel in the 5' regulatory region of the VIP gene was related to EN300 (Zhou et al, 2010).…”

Section: Discussionsupporting

confidence: 59%

Polymorphisms associated with egg number at 300 days of age in chickens

Zeng²,

Zhang³

et al. 2011

Genet. Mol. Res.

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Section: Discussionsupporting

confidence: 59%

Polymorphisms associated with egg number at 300 days of age in chickens

Zeng²,

Zhang³

et al. 2011

Genet. Mol. Res.

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“…Prolactin secretion in birds is under the stimulatory control of vasoactive intestinal peptide (VIP). Active immunization with VIP results in a substantial reduction in the plasma prolactin concentration and an increase in flock egg production due to the elimination of incubation behavior [53].…”

Section: Discussionmentioning

confidence: 99%

Comparative Changes in the Serum Concentrations of Inhibin-B, Prolactin, Gonadotropins and Steroid Hormones at Different Reproductive States in Domestic Turkey Hens

Khalil

Hanafy

Saleh

et al. 2009

Journal of Reproduction and Development

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Abstract. The present study was undertaken to compare the changes in circulating levels of inhibin-B, prolactin, follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol-17β, progesterone and testosterone during the different reproductive states of turkey hens. Blood samples were collected during different reproductive states, at laying, incubating and out of lay. Inhibin-B was measured by ELISA, while other hormones were determined by Chemiluminescent Microparticle Immunoassay (CMIA). The results revealed highly significant differences among the hen's states for all serum hormone concentrations. The highest levels of inhibin-B and prolactin were observed in incubating hens, while the lowest values were observed in laying hens. In contrast, the highest levels of FSH, LH, estradiol-17β, progesterone and testosterone were found in the laying group, while the lowest values were found in the incubating group. The progesterone level was higher in the laying group compared with the other groups. These results clearly demonstrate that negative correlation was found between both the inhibin-B and prolactin levels and the gonadotropin and steroid hormone concentrations during the different reproductive states of the turkey hens. In addition, the results suggest that inhibin-B may be involved in control of FSH and LH secretion. . The existence of bioactive inhibin in testis preparations [3,4] and ovarian granulosa cells [5,6] has been reported. The effect of induction of ovarian regression and removal of ovarian follicles on plasma inhibin indicate that the ovary is the major source of inhibin in the hen [7,8]. Prolactin secretion from the avian anterior pituitary gland is principally maintained by tonic stimulation from hypothalamic prolactinreleasing factors [9]. Prolactin secretion markedly changes during the reproductive cycle of the turkey hen. The hyperprolactinemia associated with incubation behavior (broodiness) induces ovarian regression, resulting in a substantial loss of egg production in commercial breeder flocks [10]. Administration of exogenous prolactin suppresses plasma gonadotropins necessary for egg production in domestic fowl [11]. However, there is additional evidence that suppression of gonadotropin secretion in incubating birds also involves a mechanism independent of increased prolactin secretion [12,13]. In turkey hens, the changes in the concentrations of inhibin-B, prolactin, gonadotropins and progesterone have been poorly documented. Therefore, in the present study, we investigated the changes in inhibin-B, prolactin, FSH, luteinizing hormone (LH), estradiol-17β, progesterone and testosterone hormones during the different reproductive states. Materials and Methods Animals and experimental designDomestic turkey hens (local Egyptian strain) were used in the present study. The turkeys were in the first year of production. The hens received a stimulatory photoperiod of 14 h of light:10 h of dark throughout the experimental period and were maintained in floor pens with trap nests. They...

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“…Furthermore, PRL secretion induced by hypothalamic extract can be blocked by immunoneutralization with anti-porcine VIP (pVIP) in turkeys [11]. Active immunization of turkeys against endogenous VIP prevents the expression of incubation beAccepted February 12, 1994 havior while increasing egg production [12] and abolishes PRL release from electrically stimulated hypothalami [13]. These data suggest that VIP is a PRL-releasing factor in avian species.…”

Section: Introductionmentioning

confidence: 96%

Role of Vasoactive Intestinal Peptide in the Control of Prolactin-Induced Turkey Incubation Behavior. I. Acute Infusion of Vasoactive Intestinal Peptide1

Pitts

Youngren

Silsby

et al. 1994

Biology of Reproduction

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Vasoactive intestinal peptide (VIP) stimulates prolactin (PRL) secretion. Ovine PRL induces incubation behavior in avian species. This study was designed to determine whether VIP can elevate plasma PRL for up to 3 h. Saline or porcine VIP (pVIP; 30, 60, or 150 ng/min) was infused into the median eminence of laying turkeys for 1 h. The 60- and 150-ng doses of pVIP increased plasma PRL (p < 0.01), whereas the 30-ng dose was insignificant. Pituitary PRL content decreased in pVIP-treated turkeys. Two-hour infusion of 60 or 150 ng chicken VIP (cVIP)/min produced similar elevations of plasma PRL (p < 0.001), which declined within 80 min. Both treatments induced insignificant increases in pituitary PRL mRNA. Saline or cVIP (30, 60, or 60 [pulsed] ng/min) was infused into the median eminence for 3 h. Sixty ng cVIP/min induced the largest PRL release (p < 0.05). The pulsatile and low-cVIP treatments resulted in release of a significant amount of PRL in comparison to the saline treatment (p < 0.01). All cVIP treatments resulted in decreased pituitary PRL content (p < 0.05). The 60-ng dose increased PRL mRNA (p < 0.1). This study shows that 60 ng VIP/min causes the maximum PRL release in laying turkeys. However, pituitary PRL content is depleted and PRL synthesis cannot maintain PRL secretion at high levels.

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Increased Egg Production by Active Immunization against Vasoactive Intestinal Peptide in the Turkey (Meleagris gallopavo)1

Cited by 70 publications

References 26 publications

Polymorphisms associated with egg number at 300 days of age in chickens

Polymorphisms associated with egg number at 300 days of age in chickens

Comparative Changes in the Serum Concentrations of Inhibin-B, Prolactin, Gonadotropins and Steroid Hormones at Different Reproductive States in Domestic Turkey Hens

Role of Vasoactive Intestinal Peptide in the Control of Prolactin-Induced Turkey Incubation Behavior. I. Acute Infusion of Vasoactive Intestinal Peptide1

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