Increased Elabela levels in the acute ST segment elevation myocardial infarction patients

Abstract

Elabela is a bioactive peptide and a part of Apelinergic system. Elabela has an important role in the early embryonic stages. Elabela's beneficial effects in cardiovascular system were shown in some animal models or in vitro studies. Lately, some investigational studies in humans are started to be seen in literature. Our aims were to investigate serum Elabela levels in the first day of ST segment elevation myocardial infarction (STEMI), to compare with healthy controls, and to see if there is a correlation between other cardiac biomarkers in humans.The study was planned as cross-sectional. The patients group had 124 STEMI subjects. They were grouped as inferior (n = 59) and anterior myocardial infarction (n = 65) groups, and compared with the healthy control population (n = 77). Routine blood tests and serum Elabela levels were measured. Transthoracic echocardiography performed to all subjects.Frequency of diabetes mellitus, hypertension, smoking, and hyperlipidemia in both STEMI groups were significantly higher than control subjects. Glucose, high density lipoprotein (HDL) cholesterol, triglyceride, high sensitive C reactive protein (Hs-CRP), troponin I, N-terminal brain natriuretic peptide (NT-ProBNP), and Elabela levels were significantly higher in both STEMI groups. Other laboratory parameters were similar. Group 2 and 3 had significantly lower left ventricular ejection fraction (LVEF) than group 1. Group 3 had also significantly lower LVEF than group 2. There was a positive but moderate correlation between Elabela, troponin I, and NT-ProBNP. Elabela was negatively correlated with LVEF. This correlation was also moderate.We showed increased Elabela levels in STEMI patients in this study. Also, we observed a moderate positive correlation between troponin I, NT-ProBNP, and Elabela.

Apela improves cardiac and renal function in mice with acute myocardial infarction

“…Sato et al showed that apela can prevent pressure overload heart failure caused by transverse aortic constriction in mice 27 . Yurdaer et al found that the apela level was positively correlated with NT‐proBNP ( r = 0.586, P < 0.05), whereas the levels of apela (( r = −0.551, P < 0.05) or NT‐proBNP ( r = −0.684, P < 0.05) were negatively correlated with LVEF in patients with acute MI 14 . BNP or NT‐proBNP is an important biomarker to evaluate the severity and prognosis of heart function.…”

“…13 Recently, clinical studies have shown that endogenous plasma apela levels are higher in patients with acute myocardial infarction (MI) than in healthy controls; furthermore, apela levels are also negatively correlated with left ventricular ejection fraction (LVEF). 14 These basic experiments and clinical studies suggest that apela is valuable in the diagnosis and treatment of cardiovascular disease. In this study, we prepared a heart failure model of MI in mice to further investigate the effects of exogenous apela intervention on the heart and kidney function of mice with AMI as well as to explore the possible underlying mechanisms.…”

“…Exogenous apela can also reduce pulmonary arterial pressure in mice pulmonary hypertension models 13 . Recently, clinical studies have shown that endogenous plasma apela levels are higher in patients with acute myocardial infarction (MI) than in healthy controls; furthermore, apela levels are also negatively correlated with left ventricular ejection fraction (LVEF) 14 . These basic experiments and clinical studies suggest that apela is valuable in the diagnosis and treatment of cardiovascular disease.…”

Plasma Level of Elabela in Patients with Coronary Heart Disease and Its Correlation with the Disease Classification

“…In an animal test, the infusion of ELA im- proved cardiac dysfunction, hypertrophy, and fibrosis. 15,16) In a recent report, Dönmez, et al 9) have found that the ELA levels increased in patients with STEMI. In addition, they observed a moderate positive correlation between troponin I and ELA.…”

“…8) However, so far, there is only one clinical data on the association between ELA level and ST elevation myocardial infarction (STEMI). 9) The present study was conducted to clarify the circulating ELA concentrations in patients with CHD and reveal the relationship with CHD and the disease classification.…”