1990
DOI: 10.1111/j.1365-2249.1990.tb03290.x
|View full text |Cite
|
Sign up to set email alerts
|

Increased elastase secretion by peripheral blood monocytes in cystic fibrosis patients

Abstract: SUMMARYMorbidity and mortality in cystic fibrosis (CF) is predominantly due to destruction of pulmonary tissue. The host immutie response may, in part, play a pathogenic role in pulmonary destruction in ihcsc patients. To further understand host immune response in CF, we examined the state of activation of peripheral blood monocytes in CF. Baseline elastase activity was 2-2-fold greater in the CF monocytes than in controls. Pseudonwnasaeruginosa mucoi Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
4
0

Year Published

1993
1993
2021
2021

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 12 publications
(4 citation statements)
references
References 27 publications
0
4
0
Order By: Relevance
“…CF MΦs dysfunction have been associated with altered activation defined by metabolic hyperactivity, with elevated production of pro-inflammatory cytokines 7 , elastase 8 and tissue damage mediators (termed ciliary dyskinesia substances). These mediators impact airway epithelial cell ciliary movements contributing to the accumulation of mucus secretion 9 .…”
Section: Monocyte/macrophage Alterations In Cf Are Due To Both Intrinmentioning
confidence: 99%
“…CF MΦs dysfunction have been associated with altered activation defined by metabolic hyperactivity, with elevated production of pro-inflammatory cytokines 7 , elastase 8 and tissue damage mediators (termed ciliary dyskinesia substances). These mediators impact airway epithelial cell ciliary movements contributing to the accumulation of mucus secretion 9 .…”
Section: Monocyte/macrophage Alterations In Cf Are Due To Both Intrinmentioning
confidence: 99%
“…To distinguish between phlogistic and nonphlogistic recruitment of monocytes, we developed a functional assay for measuring the levels of elastase produced in real time by monocytes accumulating in the nanoliter chambers. Elastase, a serine protease that hydrolyses amides and esters, is an enzyme up-regulated following phlogistic activation of monocytes (27). We validated this assay by quantifying elastase release in neutrophils, a cell type known to secrete high levels of this protein upon activation.…”
Section: Lxa 4 Rvd1 and Nprms Significantly Reduce Monocyte And Nementioning
confidence: 99%
“…Other innate immune populations that are of particular interest because of their ability to directly influence T‐cell responses, which are known to be dysregulated in CF, are monocytes and DCs, both of which express CFTR . While CF monocytes have been reported to have defects in adhesion, secretion of IL‐8, proteinase and elastase and complement‐mediated phagocytosis of pathogens such as P. aeruginosa, these studies have all investigated monocytes as one heterogeneous population.…”
Section: Discussionmentioning
confidence: 99%