Increased ethanol intake after prenatal ethanol exposure: Studies with animals

Chotro, M. Gabriela; Arias, Carlos F.; Laviola, Giovanni

doi:10.1016/j.neubiorev.2006.06.021

Cited by 108 publications

(121 citation statements)

References 107 publications

(168 reference statements)

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“…In genetically heterogenous rats ethanol's activating effects have been rarely reported, and what seems to predominate is motor suppression Erickson & Kochhar, 1985;Salamone et al, 2006). When focusing on the ontogeny of genetically heterogenous rats, recent studies consistently indicate heightened affinity for ethanol ingestion and marked sensitivity to ethanol's reinforcing properties during early stages in development (Chotro et al, 2007;Spear and Molina, 2005).It has been recently reported that Sprague-Dawley infants similar to those in the present study consume, without the need of initiation procedures, high amounts of ethanol (Sanders & Spear, 2007;Truxell & Spear, 2004). These animals have also been observed to readily manifest biphasic motivational properties of ethanol.…”

supporting

confidence: 61%

“…These effects are partially regulated by fetal learning comprising ethanol's chemosensory cues and the contingency between these cues and ethanol's postaborptive effects (Chotro et al, 2007;Molina, Spear, Spear, Mennella, & Lewis, 2007;Spear and Molina, 2005). In animal models of Fetal Alcohol Syndrome, in which animals are chronically exposed to high ethanol doses in utero, marked behavioral and physiological changes in response to an ethanol challenge have been observed.…”

Section: Discussionmentioning

confidence: 99%

“…This association between prenatal ethanol exposure and later affinity for the drug has been detected in various strains of rats and mice when using a variety of modes of ethanol exposure during pregnancy (Chotro, Arias, & Laviola, 2007). Heightened ethanol consumption resulting from gestational exposure to ethanol has been observed through tests conducted during different ontogenetic periods, including infancy, adolescence and adulthood (Chotro et al, 2007;.…”

mentioning

confidence: 94%

“…This moderate prenatal ethanol treatment results in high ethanol intake during infancy (Arias & Chotro, 2005a, 2005bChotro & Arias, 2003;Dominguez, Lopez, & Molina, 1998;Molina, Chotro, & Dominguez, 1995;Pueta, Abate, Spear, & Molina, 2005) as well as during adolescence (Chotro & Arias, 2003). In these studies, processing of ethanol-related chemosensory information by late-term fetuses seems to predispose the organism to accept ethanol odor and taste (Chotro et al, 2007;). Yet, the participation of other intervenient factors in this effect can not be completely rule out.…”

mentioning

confidence: 98%

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Acute sensitivity and acute tolerance to ethanol in preweanling rats with or without prenatal experience with the drug

Arias

Molina

Mlewski

et al. 2008

Pharmacology Biochemistry and Behavior

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The present study examined behavioral sensitivity and acute tolerance to ethanol in infants with or without a moderate prenatal ethanol experience. During gestational days 17-20 dams received 0.0 or 2.0 g/kg ethanol. On postnatal day 13 pups were administered 0.0, 0.5 or 2.5 g/kg ethanol prior to assessment of locomotion. One third of the pups were evaluated at 5-10, 30-35 and 60-65 min after ethanol administration; another third was tested only during the last two post-administration periods; and the remaining third was tested only at 60-65 min. At 30-35 min blood ethanol levels were similar to those attained at 60-65 min. The main results of the study were: (a) The 2.5 g/kg ethanol dose induced biphasic motor effects: stimulation 5-10 minutes after drug administration and sedation after 30-35 or 60-65 minutes. (b) Infants exhibited acute tolerance to ethanol's sedative effects. (c) Although pups prenatally treated with ethanol exhibited heightened locomotor activity levels, acute sensitivity and tolerance were not affected by prenatal treatment. In summary, infants are sensitive to biphasic motor consequences of ethanol and readily exhibit acute tolerance to ethanol's sedative effects. In addition, moderate prenatal ethanol exposure was sufficient to induce hyper-reactivity in the offspring without affecting habituation. KeyboardsPrenatal ethanol; ethanol acute sensitivity; ethanol acute tolerance; locomotor activity; habituation; infant and rat There is a considerable body of experimental evidence indicating that prenatal exposure to ethanol can critically modulate subsequent ethanol intake. This association between prenatal ethanol exposure and later affinity for the drug has been detected in various strains of rats and mice when using a variety of modes of ethanol exposure during pregnancy (Chotro, Arias, & Laviola, 2007). Heightened ethanol consumption resulting from gestational exposure to ethanol has been observed through tests conducted during different ontogenetic periods, including infancy, adolescence and adulthood (Chotro et al., 2007;. Recent epidemiologic studies have found results analogous to those reported in this preclinical research. Even when controlling genetic and environmental factors known to modulate ethanol * Corresponding author. Center for Developmental Psychobiology, Binghamton University, Binghamton, NY 13902-6000, USA Email Address afelicidade@yahoo.es. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript affinity, prenatal exposure to ethanol st...

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supporting

confidence: 61%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 94%

mentioning

confidence: 98%

See 2 more Smart Citations

Acute sensitivity and acute tolerance to ethanol in preweanling rats with or without prenatal experience with the drug

Arias

Molina

Mlewski

et al. 2008

Pharmacology Biochemistry and Behavior

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“…Deleterious actions of alcohol in the embryo and the fetus include alterations in neurochemical systems (e.g., GABA, dopamine; endogenous opioids) and neuroendocrinological processes (stressrelated reactivity mediated by the HPA axis) known to modulate behavioral affinity for alcohol (for reviews see Chotro, Arias, & Laviola, 2006;Spear & Molina, 2005). Beyond these effects, it seems necessary to consider that intrauterine exposure to alcohol can also trigger fetal sensory and learning capabilities about alcohol, even when the level of exposure is well below that for which teratogenic effects have currently been documented.…”

Section: Alcohol Responsiveness As a Function Of Fetal Experiences Wimentioning

confidence: 99%

The International Society for Developmental Psychobiology 39th Annual Meeting Symposium: Alcohol and Development: Beyond fetal alcohol syndrome

Molina

Spear

et al. 2007

Developmental Psychobiology

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As has been repeatedly demonstrated, alcohol can exert deleterious morphological and physiological effects during early stages in development. The present review examines nonteratological links existing between alcohol and ontogeny. Human and animal studies are taken into consideration for the analysis of fetal, neonatal, infantile, adolescent, and adult responsiveness to the drug. Sensitivity to alcohol's chemosensory and postabsorptive properties, as well as learning and memory processes mediated by such properties, are examined from this developmental perspective. The studies under discussion indicate that, within each stage in development, we can trace alcohol-related experiences capable of determining or modulating alcohol seeking and intake patterns.

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