Increased exhaled breath condensate 8‐isoprostane after a swimming session in competitive swimmers

Morissette, Mathieu C.; Murray, Nicolas; Turmel, Julie; Milot, Julie; Boulet, Louis‐Philippe; Bougault, Valérie

doi:10.1080/17461391.2015.1063702

Cited by 14 publications

(7 citation statements)

References 38 publications

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“…Habitual level of physical activity may impact 8-isoprostane production [46], and its elevation in the EBC was found in a study by Kurti et al after exhaustive exercise for postmenopausal women [47]. The effect of intense work on MDA, another oxidative stress marker, is more complex.…”

Section: Physical Activitymentioning

confidence: 96%

Three-Year Study of Markers of Oxidative Stress in Exhaled Breath Condensate in Workers Producing Nanocomposites, Extended by Plasma and Urine Analysis in Last Two Years

et al. 2020

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Human data concerning exposure to nanoparticles are very limited, and biomarkers for monitoring exposure are urgently needed. In a follow-up of a 2016 study in a nanocomposites plant, in which only exhaled breath condensate (EBC) was examined, eight markers of oxidative stress were analyzed in three bodily fluids, i.e., EBC, plasma and urine, in both pre-shift and post-shift samples in 2017 and 2018. Aerosol exposures were monitored. Mass concentration in 2017 was 0.351 mg/m3 during machining, and 0.179 and 0.217 mg/m3 during machining and welding, respectively, in 2018. In number concentrations, nanoparticles formed 96%, 90% and 59%, respectively. In both years, pre-shift elevations of 50.0% in EBC, 37.5% in plasma and 6.25% in urine biomarkers were observed. Post-shift elevation reached 62.5% in EBC, 68.8% in plasma and 18.8% in urine samples. The same trend was observed in all biological fluids. Individual factors were responsible for the elevation of control subjects’ afternoon vs. morning markers in 2018; all were significantly lower compared to those of workers. Malondialdehyde levels were always acutely shifted, and 8-hydroxy-2-deoxyguanosine levels best showed chronic exposure effect. EBC and plasma analysis appear to be the ideal fluids for bio-monitoring of oxidative stress arising from engineered nanomaterials. Potential late effects need to be targeted and prevented, as there is a similarity of EBC findings in patients with silicosis and asbestosis.

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Section: Physical Activitymentioning

confidence: 96%

Three-Year Study of Markers of Oxidative Stress in Exhaled Breath Condensate in Workers Producing Nanocomposites, Extended by Plasma and Urine Analysis in Last Two Years

et al. 2020

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“…Interestingly, CC16 gene polymorphism has been associated with BHR . It has been recently evidenced that levels of 8‐isoprostane in exhaled breath condensate increase after training in swimmers, suggesting that exercise‐induced hyperpnoea in a chlorinated pool environment increases airways oxidative stress . The evidence in a mouse model that BHR can be induced by a single hypochlorite‐ovalbumin instillation, independently of bronchial influx of inflammatory cell, highlighted the role of transient receptor potential ankyrin 1 (TRPA1) channel on nociceptive airway sensory nerves in nonallergic BHR .…”

Section: Future Perspectivesmentioning

confidence: 99%

Mechanisms of exercise‐induced bronchoconstriction in athletes: Current perspectives and future challenges

Couto

Kurowski

Moreira

et al. 2017

Allergy

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The evidence of exercise-induced bronchoconstriction (EIB) without asthma (EIBw A ) occurring in athletes led to speculate about different endotypes inducing respiratory symptoms within athletes. Classical postulated mechanisms for bronchial obstruction in this population include the osmotic and the thermal hypotheses. More recently, the presence of epithelial injury and inflammation in the airways of athletes was demonstrated. In addition, neuronal activation has been suggested as a potential modulator of bronchoconstriction. Investigation of these emerging mechanisms is of major importance as EIB is a significant problem for both recreational and competitive athletes and is the most common chronic condition among Olympic athletes, with obvious implications for their competing performance, health and quality of life. Hereby, we summarize the latest achievements in this area and identify the current gaps of knowledge so that future research heads toward better defining the etiologic factors and mechanisms involved in development of EIB in elite athletes as well as essential aspects to ultimately propose preventive and therapeutic measures. K E Y W O R D Sepithelial injury, neurogenic inflammation, osmotic, sports, thermal

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“…Chlorine and its by-products are strong oxidants, which may irritate the airways and are considered increasingly responsible for the occurrence of respiratory disorders in swimmers. There is a recent report on isoprostanes in swimmers [20], where researchers found increased levels of 8-isoprostane in exhaled breath condensate 10 min after the training session, highlighting the impact of exercise-induced hyperpnoea on oxidative stress. We corroborated those data and showed marked airway and systemic oxidative stress during the high training period, indicating that the problem of airway oxidative stress is not only an » acute « airway problem, linked to hyperpnoea.…”

Section: Discussionmentioning

confidence: 99%

Systemic and airway oxidative stress in competitive swimmers

Škrgat

Marčun

Kern

et al. 2018

Respiratory Medicine

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Increased exhaled breath condensate 8‐isoprostane after a swimming session in competitive swimmers

Abstract: EBC 8-IsoP levels were increased after training in swimmers but not in lifeguards, suggesting that exercise-induced hyperpnoea in a chlorinated pool environment increases airways oxidative stress.

Cited by 14 publications

References 38 publications

Three-Year Study of Markers of Oxidative Stress in Exhaled Breath Condensate in Workers Producing Nanocomposites, Extended by Plasma and Urine Analysis in Last Two Years

Three-Year Study of Markers of Oxidative Stress in Exhaled Breath Condensate in Workers Producing Nanocomposites, Extended by Plasma and Urine Analysis in Last Two Years

Mechanisms of exercise‐induced bronchoconstriction in athletes: Current perspectives and future challenges

Systemic and airway oxidative stress in competitive swimmers

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