Increased expression of A-kinase anchoring proteins in T cells from systemic lupus erythematosus patients

Pérez-Lorenzo, María Jesús; Galindo, María; García-González, Araceli; Criado, Gabriel

doi:10.1186/1479-5876-8-s1-p49

Cited by 2 publications

(2 citation statements)

References 2 publications

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“…In conclusion, PKA seems to be important in the development of autoimmune diseases such as SLE. The expression of AKAP9 and AKAP79 is elevated in T cells from patients with SLE; nevertheless, the causes remain unknown [ 70 ].…”

Section: Akaps Are Involved In Immunological Processesmentioning

confidence: 99%

Role of Protein Kinase A Activation in the Immune System with an Emphasis on Lipopolysaccharide-Responsive and Beige-like Anchor Protein in B Cells

Pérez-Pérez

Santos‐Argumedo

Rodríguez-Alba

et al. 2023

IJMS

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Cyclic AMP-dependent protein kinase A (PKA) is a ubiquitous enzymatic complex that is involved in a broad spectrum of intracellular receptor signaling. The activity of PKA depends on A-kinase anchoring proteins (AKAPs) that attach to PKAs close to their substrates to control signaling. Although the relevance of PKA-AKAP signaling in the immune system is evident in T cells, its relevance in B and other immune cells remains relatively unclear. In the last decade, lipopolysaccharide-responsive and beige-like anchor protein (LRBA) has emerged as an AKAP that is ubiquitously expressed in B and T cells, specifically after activation. A deficiency of LRBA leads to immune dysregulation and immunodeficiency. The cellular mechanisms regulated by LRBA have not yet been investigated. Therefore, this review summarizes the functions of PKA in immunity and provides the most recent information regarding LRBA deficiency to deepen our understanding of immune regulation and immunological diseases.

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Section: Akaps Are Involved In Immunological Processesmentioning

confidence: 99%

Role of Protein Kinase A Activation in the Immune System with an Emphasis on Lipopolysaccharide-Responsive and Beige-like Anchor Protein in B Cells

Pérez-Pérez

Santos‐Argumedo

Rodríguez-Alba

et al. 2023

IJMS

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“…The inhibitory role of the R-subunits is indicative of their role as tumor suppressors in CNC-associated tumors [65,66]. Decreased expression of the R-subunits (30% decrease in RIα and 65% decrease in RIβ) is associated with the idiopathic autoimmune disease called systemic lupus erythematosus (SLE) that is characterized by impaired T-lymphocyte functions [67,68]. PKA is reported to play a critical role in the regulation of metabolism and triglyceride storage, such that it is a lucrative target for therapeutic targeting or obesity and aging [69,70].…”

Section: Pka and Human Diseasementioning

confidence: 99%

Interaction Networks Explain Holoenzyme Allostery in Protein Kinase A

Welsh,

Conklin,

Madan

2023

Kinases and Phosphatases

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Protein kinase A (PKA) signaling exemplifies phosphorylation-based signaling as we understand it today. Its catalytic-subunit structure and dynamics continue to advance our understanding of kinase mechanics as the first protein kinase catalytic domain to be identified, sequenced, cloned, and structurally detailed. The PKA holoenzyme elaborates on the role of its regulatory subunits and maintains our understanding of cAMP-dependent cellular signaling. The activation of PKA holoenzymes by cAMP is an example of specialized protein allostery, emphasizing the relevance of protein binding interfaces, unstructured regions, isoform diversity, and dynamics-based allostery. This review provides the most up-to-date overview of PKA structure and function, including a description of the catalytic and regulatory subunits’ structures. In addition, the structure, activation, and allostery of holoenzymes are covered.

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Increased expression of A-kinase anchoring proteins in T cells from systemic lupus erythematosus patients

Cited by 2 publications

References 2 publications

Role of Protein Kinase A Activation in the Immune System with an Emphasis on Lipopolysaccharide-Responsive and Beige-like Anchor Protein in B Cells

Role of Protein Kinase A Activation in the Immune System with an Emphasis on Lipopolysaccharide-Responsive and Beige-like Anchor Protein in B Cells

Interaction Networks Explain Holoenzyme Allostery in Protein Kinase A

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