Increased expression of damage-associated molecular patterns (DAMPs) in osteoarthritis of human knee joint compared to hip joint

Abstract

Osteoarthritis (OA) is a degenerative disease characterized by the destruction of cartilage. The greatest risk factors for the development of OA include age and obesity. Recent studies suggest the role of inflammation in the pathogenesis of OA. The two most common locations for OA to occur are in the knee and hip joints. The knee joint experiences more mechanical stress, cartilage degeneration, and inflammation than the hip joint. This could contribute to the increased incidence of OA in the knee joint. Damage-associated molecular patterns (DAMPs), including high-mobility group box-1, receptor for advanced glycation end products, and alarmins (S100A8 and S100A9), are released in the joint in response to stress-mediated chondrocyte and cartilage damage. This facilitates increased cartilage degradation and inflammation in the joint. Studies have documented the role of DAMPs in the pathogenesis of OA; however, the comparison of DAMPs and its influence on OA has not been discussed. In this study, we compared the DAMPs between OA knee and hip joints and found a significant difference in the levels of DAMPs expressed in the knee joint compared to the hip joint. The increased levels of DAMPs suggest a difference in the underlying pathogenesis of OA in the knee and the hip and highlights DAMPs as potential therapeutic targets for OA in the future.

Effect of Perioperative Opioids on Cancer-Relevant Circulating Parameters: Mu Opioid Receptor and Toll-Like Receptor 4 Activation Potential, and Proteolytic Profile

“…inherent to the pathology underlying the need for surgery (18) and in line with the increased MMP-9 and increased TIMP-1 observed in the preoperative patient samples compared with the healthy controls ( Supplementary Fig. S3).…”

The potential roles of high mobility group box 1 (HMGB1) in musculoskeletal disease: A systematic review

“…A total of 4376 abstracts were screened, and 168 articles were selected for full‐text article screening (Figure 1). After full‐text article screening, 66 articles were included in the systematic review as they fulfilled all selection criteria 13,15,23‐27,32‐91 . Although most studies focused on either human musculoskeletal disease (n = 31) or animal models of musculoskeletal disease (n = 31), four studies investigated HMGB1 in both human and animal models of musculoskeletal disease (Tables 1 and 2).…”

“…There were 35 studies that investigated HMGB1 in human musculoskeletal diseased tissue, including arthritis (27), fractures (1), IVD degeneration (4), tendinopathy (2), and frozen shoulder (1) (Table 1). 23‐26,32,33,36,38,39,41‐43,45,46,56‐58,60,62,64,66,68,69,71,75‐77,80‐82,85,88‐91 Most studies that investigated HMGB1 expression (26/28) showed that HMGB1 expression is increased in human musculoskeletal diseased tissues compared to control tissues (Table 3). 24‐26,32,33,36,38,39,41‐43,45,46,56‐58,60,62,64,66,68,69,71,75‐77,80‐82,85,88,89,91 The redox status of HMGB1 was not investigated in these studies of human musculoskeletal disease.…”

“…Twenty‐seven studies investigated the role of HMGB1 in human arthritis, including (post‐traumatic) OA, RA, JIA, SLE, and (pseudo)gout 26,32,33,39,41,42,45,46,56‐58,60,62,64,68,69,71,75‐77,80‐82,85,88‐91 . In 20 of 21 studies, HMGB1 expression was increased in diseased tissues compared to control tissues (Table 3).…”

Diabetes mellitus does not increase the risk of knee stiffness after total knee arthroplasty: a meta-analysis of 7 studies including 246 053 cases

“…Diabetes mellitus is known to cause crosslinking of collagen due to the formation of AGEs [24]. A recent study has shown increased expression of damage-associated molecular patterns (DAMPs), including high-mobility group box-1, the receptor for advanced glycation end products, and alarmins (S100A8 and S100A9) in the knee compared to the hip joint [30]. This is thought to facilitate increased cartilage degradation and inflammation.…”