Increased expression of epidermal thymic stromal lymphopoietin in inflammatory peeling skin syndrome

Wada, Taizo; Toma, Tomoko; Hamaguchi, Yasuhito; Yachie, Akihiro

doi:10.1111/1346-8138.12449

Cited by 4 publications

(4 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Subjects with AD and lesional skin have been shown to overexpress thymic stromal lymphopoietin (TSLP). 42,43 TSLP can activate various cell types by binding to its receptor on target cells. Dendritic cells (DCs) are one of the primary targets for TSLP, and on receptor activation, TSLP can upregulate the expression of CD80, CD86, and OX40L on DCs, thereby promoting T-helper type 2 (Th2) polarization and the production of the Th2 cytokines IL-4, IL-5, and IL-13 in both human in vitro and animal models.…”

Section: Benefits Of Testing and Food Elimination Clinical Benefitsmentioning

confidence: 99%

Atopic Dermatitis and Food Allergy: Best Practices and Knowledge Gaps—A Work Group Report from the AAAAI Allergic Skin Diseases Committee and Leadership Institute Project

Singh

Anvari

Hauk

et al. 2022

The Journal of Allergy and Clinical Immunology: In Practice

View full text Add to dashboard Cite

Section: Benefits Of Testing and Food Elimination Clinical Benefitsmentioning

confidence: 99%

Atopic Dermatitis and Food Allergy: Best Practices and Knowledge Gaps—A Work Group Report from the AAAAI Allergic Skin Diseases Committee and Leadership Institute Project

Singh

Anvari

Hauk

et al. 2022

The Journal of Allergy and Clinical Immunology: In Practice

View full text Add to dashboard Cite

“…Its expression can be further enhanced through exposure to viral, bacterial, or parasitic pathogens as well as TLR agonists . Although TSLP expression was undetectable in normal skin, it was found to be highly expressed in the lesional skin of individuals with atopic dermatitis, in skin biopsies from patients with peeling skin syndrome type B, and in the airways of asthmatics . TSLP levels in asthmatic airways correlated with Th2‐attracting chemokine expression and disease severity .…”

Section: Epithelial Cell‐derived Cytokines and The Atopic Marchmentioning

confidence: 99%

The atopic march: current insights into skin barrier dysfunction and epithelial cell‐derived cytokines

Han¹,

Roan²,

Ziegler

2017

Immunological Reviews

228

162

View full text Add to dashboard Cite

Summary Atopic dermatitis often precedes the development of other atopic diseases. The atopic march describes this temporal relationship in the natural history of atopic diseases. Although the pathophysiological mechanisms that underlie this relationship are poorly understood, epidemiological and genetic data have suggested that the skin might be an important route of sensitization to allergens. Animal models have begun to elucidate how skin barrier defects can lead to systemic allergen sensitization. Emerging data now suggest that epithelial cell-derived cytokines such as thymic stromal lymphopoietin (TSLP), IL-33, and IL-25 may drive the progression from atopic dermatitis to asthma and food allergy. This review focuses on current concepts of the role of skin barrier defects and epithelial cell-derived cytokines in the initiation and maintenance of allergic inflammation and the atopic march.

show abstract

“…Экспрессия TSLP повышена при многих аллергических заболеваниях, обусловленных активацией Тh2, таких как атопический дерматит и БА, и коррелирует с тяжестью клинических проявлений аллергии [5]. С другой стороны, TSLP участвует в регуляции ряда гомеостатических функций, в т. ч. нормальной физиологической дифференцировки Т-лимфоцитов в тимусе.…”

Section: Allergology / Immunologyunclassified

Cytokines and their role in immune pathogenesis of allergy

As¹

2021

Russian Medical Inquiry

View full text Add to dashboard Cite

Allergy is characterized by inadequate hyperimmune response to one or several antigens with the properties of allergens. A specific pattern of abnormal synthesis of some cytokines (principal molecular mediators of the initiation, development, and regulation of allergic inflammation) has an important pathogenic role in allergy. In recent years, it is generally accepted that allergic disorders are accounted for by impaired immune regulation resulting from increased imbalanced activation of allergen-specific T helper 2 cell clones. Allergic type of immune response is currently referred to as type 2 immune response which normally provides humoral immunity, anthelmintic protection etc. However, pathological response results in allergy. Studies on immune pathogenesis of allergic disorders have improved our understanding of the role of altered synthesis of some cytokines (key mediators of allergic inflammation). Cytokines involved in the initiation and regulation of allergy are produced by epithelial cells, various subsets of leukocytes, innate lymphoid cells, and allergen-activated T helper cell clones. Analysis of the associations of the changes in immune reactivity and clinical manifestations has established pathogenic heterogeneity and identified asthma phenotypes and endotypes. These findings have provided a basis for more reasonable, successful, and personalized approach to biological anti-cytokine treatment for allergic disorders. KEYWORDS: allergy, cytokines, T helper cell clones, phenotype, asthma, anti-cytokine therapy. FOR CITATION: Simbirtsev A.S. Cytokines and their role in immune pathogenesis of allergy. Russian Medical Inquiry. 2021;5(1):32–37. DOI: 10.32364/2587-6821-2021-5-1-32-37.

show abstract

Increased expression of epidermal thymic stromal lymphopoietin in inflammatory peeling skin syndrome

Cited by 4 publications

References 10 publications

Atopic Dermatitis and Food Allergy: Best Practices and Knowledge Gaps—A Work Group Report from the AAAAI Allergic Skin Diseases Committee and Leadership Institute Project

Atopic Dermatitis and Food Allergy: Best Practices and Knowledge Gaps—A Work Group Report from the AAAAI Allergic Skin Diseases Committee and Leadership Institute Project

The atopic march: current insights into skin barrier dysfunction and epithelial cell‐derived cytokines

Cytokines and their role in immune pathogenesis of allergy

Contact Info

Product

Resources

About