Increased Expression of hsa_circ_0002111 and Its Clinical Significance in Papillary Thyroid Cancer

Du, Gongbo; Ma, Runsheng; Li, Hongqiang; He, Jing; Feng, Kexin; Niu, Dongpeng; Yin, Dengke

doi:10.3389/fonc.2021.644011

Cited by 12 publications

(14 citation statements)

References 20 publications

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“…A possible explanation might be that: circ_0015278 high expression might serve as the sponge of miR‐1228 to enhance the activity of wild type p53 (as in ovarian cancer 17 ), and the latter one is the key suppressor of thyroid tumorigenesis 19 . Meanwhile, other previous studies also suggest that several circRNAs are dysregulated in PTC 13–15 …”

Section: Discussionmentioning

confidence: 99%

“… 19 Meanwhile, other previous studies also suggest that several circRNAs are dysregulated in PTC. 13 , 14 , 15 …”

Section: Discussionmentioning

confidence: 99%

“…Besides, circRNA is regarded as a potential, clinical biomarker for it is stable and easy to extract 11,12 . In PTC, previous studies suggest that several circRNAs, including circ_0002111, circ_0006156, and circ_0137287, serve as clinical biomarkers and possess the potential to improve the management of PTC patients 13–15 . Regarding circ_0015278, it is a newly found circRNA that inhibits the progression of several cancers including non‐small cell lung cancer (NSCLC) and ovarian cancer 16,17 .…”

Section: Introductionmentioning

confidence: 99%

“… 11 , 12 In PTC, previous studies suggest that several circRNAs, including circ_0002111, circ_0006156, and circ_0137287, serve as clinical biomarkers and possess the potential to improve the management of PTC patients. 13 , 14 , 15 Regarding circ_0015278, it is a newly found circRNA that inhibits the progression of several cancers including non‐small cell lung cancer (NSCLC) and ovarian cancer. 16 , 17 Moreover, one previous study using microarray profiling finds that circ_0015278 is greatly reduced in PTC tumor tissues compared with benign thyroid lesions.…”

Section: Introductionmentioning

confidence: 99%

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Higher circular RNA_0015278 correlates with absence of extrathyroidal invasion, lower pathological tumor stages, and prolonged disease‐free survival in papillary thyroid carcinoma patients

Ding

Wang²,

Liu

et al. 2021

Clinical Laboratory Analysis

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Background Circular RNA_0015278 (circ_0015278) inhibits the progression of several cancers and is greatly reduced in papillary thyroid carcinoma (PTC) tissues compared with benign thyroid lesions by microarray profiling. This study aimed to further investigate the correlation of circ_0015278 with tumor characteristics and prognosis in PTC patients. Methods Totally, 206 PTC patients who underwent tumor resection were retrospectively enrolled; subsequently, circ_0015278 expression in their tumor and adjacent tissues was detected by reverse transcriptional‐quantitative polymerase chain reaction. Besides, disease‐free survival (DFS) and overall survival (OS) were calculated. Results Circ_0015278 was reduced in tumor tissues compared with adjacent tissues (p < 0.001), and receiver operating characteristic analysis showed that it well discriminated tumor tissues from adjacent tissues (area under curve: 0.903, 95% confidence interval: 0.874–0.932). Besides, higher tumor circ_0015278 expression was correlated with absence of extrathyroidal invasion (p = 0.036), lower pathological tumor (pT) stage (p = 0.05), pathological node (pN) stage (p = 0.002), and pathological tumor‐node‐metastasis (pTNM) stage (p = 0.001). Moreover, higher tumor circ_0015278 expression was associated with a reduced relapse rate (p = 0.011), but not mortality rate (p = 0.110); meanwhile, it was also correlated with prolonged DFS (p = 0.017), but not OS (p = 0.136). Additionally, multivariate Cox's regression analyses showed that higher tumor circ_0015278 expression independently associated with favorable DFS (p = 0.026, hazard ratio = 0.529). Conclusion Circ_0015278 is reduced in tumor tissues, while its’ higher expression in tumor correlates with absence of extrathyroidal invasion, lower pT, pN, and pTNM stage, as well as prolonged DFS in PTC patients.

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Section: Discussionmentioning

confidence: 99%

“… 19 Meanwhile, other previous studies also suggest that several circRNAs are dysregulated in PTC. 13 , 14 , 15 …”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Higher circular RNA_0015278 correlates with absence of extrathyroidal invasion, lower pathological tumor stages, and prolonged disease‐free survival in papillary thyroid carcinoma patients

Ding

Wang²,

Liu

et al. 2021

Clinical Laboratory Analysis

View full text Add to dashboard Cite

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“…Compared with normal controls, circRNAs present significantly differential expression profiles in TC tissues and blood from patients with TC; thus, they are regarded as promising and ideal candidates for the diagnosis of TC owing to their abnormal expression and high specificity (Table 2; Figure 4) (Jin et al, 2018;Lan et al 2018a;Ren et al 2018;Wang et al 2018b;Wei et al 2018;Cai et al 2019;Yao et al 2019;Wang et al 2019a;Fan et al 2020;Han et al 2020a;Hu et al 2020b;Liu et al 2020b;Sun et al 2020b;Wang et al 2020b;Wu et al 2020a;Xue et al 2020;Ye et al, 2020;Yu et al, 2020;Zhang et al 2020b;Chu et al, 2021;Ding et al 2021a;Ding et al 2021b;Du et al 2021;Guo et al 2021;Li et al 2021a;Li et al 2021b;Li et al 2021d;Lin et al 2021;Liu et al 2021b;Luo et al, 2021;Ma and Kan, 2021;Qi et al, 2021b;Xiong et al, 2021b;Zeng et al, 2021;Zhang et al 2021c;Zhang et al 2021d;Zheng et al 2021a;Zhu et al, 2021;…”

Section: Circrnas As Promising Diagnostic and Prognostic Biomarkers F...mentioning

confidence: 99%

Function and Clinical Significance of Circular RNAs in Thyroid Cancer

Yao

Zhang²

2022

Front. Mol. Biosci.

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Thyroid cancer (TC) is the leading cause and mortality of endocrine malignancies worldwide. Tumourigenesis involves multiple molecules including circular RNAs (circRNAs). circRNAs with covalently closed single-stranded structures have been identified as a type of regulatory RNA because of their high stability, abundance, and tissue/developmental stage-specific expression. Accumulating evidence has demonstrated that various circRNAs are aberrantly expressed in thyroid tissues, cells, exosomes, and body fluids in patients with TC. CircRNAs have been identified as either oncogenic or tumour suppressor roles in regulating tumourigenesis, tumour metabolism, metastasis, ferroptosis, and chemoradiation resistance in TC. Importantly, circRNAs exert pivotal effects on TC through various mechanisms, including acting as miRNA sponges or decoys, interacting with RNA-binding proteins, and translating functional peptides. Recent studies have suggested that many different circRNAs are associated with certain clinicopathological features, implying that the altered expression of circRNAs may be characteristic of TC. The purpose of this review is to provide an overview of recent advances on the dysregulation, functions, molecular mechanisms and potential clinical applications of circRNAs in TC. This review also aimes to improve our understanding of the functions of circRNAs in the initiation and progression of cancer, and to discuss the future perspectives on strategies targeting circRNAs in TC.

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Circular RNA circLIFR suppresses papillary thyroid cancer progression by modulating the miR-429/TIMP2 axis

Zhang,

Li,

et al. 2024

J Cancer Res Clin Oncol

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Purpose Circular RNAs (circRNAs) are increasingly recognized for their important roles in various cancers, including papillary thyroid cancer (PTC). The specific mechanisms by which the circLIF receptor subunit alpha (circLIFR, hsa_circ_0072309) influences PTC progression remain largely unknown. Methods In our study, CircLIFR, miR-429, and TIMP2 levels were assessed using reverse transcription-quantitative PCR. The roles of circLIFR and miR-429 in PTC cells were determined using Cell Counting Kit-8, colony formation, wound healing, and Transwell assays. Western blotting was utilized to examine the levels of TIMP2. The direct interaction between circLIFR, TIMP2, and miR-429 was confirmed using dual-luciferase reporter, RNA immunoprecipitation, and fluorescence in situ hybridization assays. Results In PTC tissues and cells, a decrease in circLIFR and TIMP2 levels, accompanied by an increase in miR-429 levels, was observed. Overexpression of circLIFR or downregulation of miR-429 effectively suppressed the proliferation and migration of PTC cells. Conversely, the knockdown of circLIFR or overexpression of miR-429 had the opposite effect. Furthermore, circLIFR overexpression suppressed tumor growth in vivo. Mechanistically, circLIFR modulated TIMP2 expression by serving as a sponge for miR-429. Rescue experiments indicated that the antitumor effect of circLIFR could be reversed by miR-429. Conclusion This study confirmed circLIFR as a novel tumor suppressor delayed PTC progression through the miR-429/TIMP2 axis. These findings suggested that circLIFR held promise as a potential therapeutic target for PTC.

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Increased Expression of hsa_circ_0002111 and Its Clinical Significance in Papillary Thyroid Cancer

Cited by 12 publications

References 20 publications

Higher circular RNA_0015278 correlates with absence of extrathyroidal invasion, lower pathological tumor stages, and prolonged disease‐free survival in papillary thyroid carcinoma patients

Higher circular RNA_0015278 correlates with absence of extrathyroidal invasion, lower pathological tumor stages, and prolonged disease‐free survival in papillary thyroid carcinoma patients

Function and Clinical Significance of Circular RNAs in Thyroid Cancer

Circular RNA circLIFR suppresses papillary thyroid cancer progression by modulating the miR-429/TIMP2 axis

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