Increased Expression of <i>c‐myc</i> Is Associated with Thymoma in Rats Infected with Murine Leukemia Virus A8

Hirano, Tomoko; Watanabe, Rihito; Takase‐Yoden, Sayaka

doi:10.1111/j.1348-0421.2005.tb03704.x

Cited by 1 publication

(1 citation statement)

References 16 publications

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“…Most thymomas are thought to arise from somatic cell transformation, although germ line changes associated with thymomas have been identified in humans 18,19 . Genetic changes observed in laboratory animal populations associated with thymoma formation include viral insertional mutagenesis causing the loss of tumour suppressor genes such as p16INK4a and ARF 20 and increased expression of oncogenes including c‐myc 21 . In a study of feline neoplasia, thymomas were found to over express bcl‐2 antiapoptotic proteins 22 .…”

Section: Discussionmentioning

confidence: 99%

The use of megavoltage radiation therapy in the treatment of thymomas in rabbits: 19 cases

Andres¹,

Kent²,

Siedlecki³

et al. 2012

Vet Comparative Oncology

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An overall median survival time (MST) and prognostic factors in rabbits with thymomas treated with megavoltage radiation therapy (RT) were determined in this multi-institutional retrospective case analysis. Medical records for 19 rabbits with suspected or confirmed thymomas treated with RT were evaluated for data including signalment, haematological and serum biochemistry abnormalities, presence of pleural effusion, radiation plan, body weight, total radiation dose and institution administering RT. Statistical significance of these factors related to overall survival was assessed. An overall MST for all 19 rabbits was 313 days; exclusion of 3 rabbits that died acutely during the first 14 days of RT yielded a MST of 727 days. The only factor associated with a significantly decreased survival time was having a body weight lower than mean body weight of 1.57 kg. Radiation treatment-associated complications were infrequent and included radiation-induced myocardial failure, radiation pneumonitis and alopecia.

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