2020
DOI: 10.1111/bpa.12865
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Increased expression of miR142 and miR155 in glial and immune cells after traumatic brain injury may contribute to neuroinflammation via astrocyte activation

Abstract: Traumatic brain injury (TBI) is associated with the pathological activation of immune‐competent cells in the brain, such as astrocytes, microglia and infiltrating immune blood cells, resulting in chronic inflammation and gliosis. This may contribute to the secondary injury after TBI, thus understanding of these processes is crucial for the development of effective treatments of post‐traumatic pathologies. MicroRNAs (miRNAs, miRs) are small noncoding RNAs, functioning as posttranscriptional regulators of gene e… Show more

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Cited by 30 publications
(27 citation statements)
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“…The distinct synaptopathy in blast‐exposed hippocampal tissue has resemblances with AD‐type neuronal compromise. Models of the more severe designation of TBI have been found to produce potential biomarkers including noncoding microRNAs, with the inflammation‐associated microRNA miR155 increased after lateral fluid‐percussion injury in rats and in the post‐TBI human cortex with evident association with activated astrocytes (39). In contrast, the subtle, early effects following small RDX detonations were not associated with astroglial activation, nor was NCAM 120 affected which is expressed mainly by glia in the CNS.…”
Section: Discussionmentioning
confidence: 99%
“…The distinct synaptopathy in blast‐exposed hippocampal tissue has resemblances with AD‐type neuronal compromise. Models of the more severe designation of TBI have been found to produce potential biomarkers including noncoding microRNAs, with the inflammation‐associated microRNA miR155 increased after lateral fluid‐percussion injury in rats and in the post‐TBI human cortex with evident association with activated astrocytes (39). In contrast, the subtle, early effects following small RDX detonations were not associated with astroglial activation, nor was NCAM 120 affected which is expressed mainly by glia in the CNS.…”
Section: Discussionmentioning
confidence: 99%
“…001973). The cDNA preparation and real‐time quantitative polymerase chain reaction (qPCR) analysis were done as previously described [28]. The primers used for the reverse transcription (RT)‐qPCR are listed in Table 3.…”
Section: Methodsmentioning
confidence: 99%
“…Western blot analysis was done as previously described [28]. The primary and secondary antibodies are described in Table 4 (application WB).…”
Section: Methodsmentioning
confidence: 99%
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