Increased expression of (pro)renin receptor in aldosterone-producing adenomas

Yamamoto, Hajime; Kaneko, Kiriko; Ohba, Koji; Morimoto, Ryo; Hirose, Takuo; Satoh, Fumitoshi; Totsune, Kazuhito; Takahashi, Kazuhiro

doi:10.1016/j.peptides.2013.08.022

Cited by 28 publications

(25 citation statements)

References 39 publications

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“…Along with the detection of the PRR in human adrenocortical tissues (see later), it suggests that prorenin plays a role in the adrenocortical cells, as shown by the marked activation of CYP11B2 transcription. A vast array of tissues, including heart, brain, placenta, liver, and pancreas, were found to express the PRR [19], but information on the human adrenal gland is limited [20]. Yamamoto et al [20] recently described the PRR in the human adrenals and adrenocortical tumours including APAs, but functional data lack, which is somewhat surprising given the key role of this gland in BP regulation.…”

Section: Discussionmentioning

confidence: 99%

“…A vast array of tissues, including heart, brain, placenta, liver, and pancreas, were found to express the PRR [19], but information on the human adrenal gland is limited [20]. Yamamoto et al [20] recently described the PRR in the human adrenals and adrenocortical tumours including APAs, but functional data lack, which is somewhat surprising given the key role of this gland in BP regulation. We herein provide evidence of a high level of the PRR mRNA in the adrenal cortex of the normal human adrenal gland and APA.…”

Section: Discussionmentioning

confidence: 99%

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Expression and functional role of the prorenin receptor in the human adrenocortical zona glomerulosa and in primary aldosteronism

Recarti¹,

Seccia

Caroccia

et al. 2015

Journal of Hypertension

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The presence of detectable plasma prorenin in primary aldosteronism patients, and the high expression of PRR in the normal human adrenal cortex, APA tissue, CD56+ aldosterone-producing cells, along with activation of CYP11B2 synthesis and ERK1/2 phosphorylation, suggest that the circulating and locally produced prorenin may contribute to the development or maintenance of human primary aldosteronism.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Expression and functional role of the prorenin receptor in the human adrenocortical zona glomerulosa and in primary aldosteronism

Recarti¹,

Seccia

Caroccia

et al. 2015

Journal of Hypertension

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“…In addition, the effect of bafilomycin A1 on the cell growth inhibition and apoptosis was remarkably enhanced by hirsutanol A in MCF-7 breast carcinoma cells (34). (P)RR was widely expressed in various types of cells and tissues including brain, kidney, adrenal and adrenal tumors, and certain cultured tumor cells (7,8,11,20,(29)(30)(31)33). However, there has been no report on expression of (P)RR in breast carcinoma tissues.…”

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confidence: 99%

Expression of (pro)renin receptor in breast cancers and its effect on cancercell proliferation

et al. 2014

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ABSTRACT(Pro)renin receptor ((P)RR) is a specific receptor for renin and prorenin. The aim of the present study is to clarify expression of (P)RR and pathophysiological roles of (P)RR in human breast carcinomas. (P)RR expression was studied in 69 clinical cases of breast carcinoma by immunohistochemistry. Effects of (P)RR on cell proliferation were examined in cultured human breast carcinoma cells using (P)RR specific small interference RNA. Immunohistochemistry showed that (P)RR immunoreactivity was detected in the breast carcinoma cells in 50 of 69 cases of breast carcinoma (72%). The analysis on association between (P)RR immunoreactivity and clinicopathological parameters showed that the number of (P)RR positive cases was significantly greater in Ki-67 (a cell proliferation marker) ≥ 10% group than in Ki-67 < 10% group (P = 0.02). (P)RR was expressed in 4 types of human breast carcinoma cell lines. (P)RR specific small interference RNA inhibited proliferation of both MCF-7 (ERα positive) and SK-BR-3 (ERα negative) cells. The present study has shown, for the first time, the expression of (P)RR in human breast carcinoma tissues and cultured breast carcinoma cell lines. These findings have raised the possibility that the blockade of the (P)RR signaling may be a novel therapeutic strategy against breast carcinomas.The renin-angiotensin system (RAS) plays important roles, not only in homeostatic regulation of blood pressure and water-electrolyte metabolism, but also in tumor biology including breast cancers. All the components of the RAS, including prorenin, renin, angiotensinogen (AGT), angiotensin I converting enzyme (ACE) and angiotensin receptors were localized in normal and cancerous breast tissues (28). Angiotensin II (Ang II) acts on the angiotensin II type 1 receptor (AT1R) to promote cell proliferation in breast cancer cells, via the protein kinase C/Ca 2+ / phosphoinositide 3-kinase pathways, and extracellular signal-related kinase (ERK) activation (32). Ang II promoted cell adhesion, invasion and metastasis of breast carcinoma by regulating the expression of integrins, vascular endothelial growth factor and matrix metalloproteinase-9 (22, 23). Clinicopathological study showed that AT1R expression in breast carcinoma tissues correlated with axillary lymph node metastasis (2). (Pro)renin receptor ((P)RR), a specific receptor for renin and prorenin, consists of 350 amino acids

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“…Moreover, (P)RR is expressed in adrenal tumors [99] and breast cancers [62]. Expression levels of (P)RR were elevated in aldosterone-secreting adenomas when compared with other types of adrenal adenomas and normal adrenal glands [99]. The suppression of (P)RR expression by (P)RR specific siRNA resulted in decrease proliferation of cultured breast cancer cells [62], suggesting that the (P)RR-mediated signaling stimulates proliferation of breast cancer cells.…”

Section: Renin-angiotensin System and (Pro)renin Receptormentioning

confidence: 99%

“…For example, expression of (P)RR has been shown in neurons [81], anterior pituitary cells [81,91], adrenal cortex and medulla [99], erythroblastic cells [29], lymphocytes and monocytes [54]. Moreover, (P)RR is expressed in adrenal tumors [99] and breast cancers [62]. Expression levels of (P)RR were elevated in aldosterone-secreting adenomas when compared with other types of adrenal adenomas and normal adrenal glands [99].…”

Section: Renin-angiotensin System and (Pro)renin Receptormentioning

confidence: 99%