Increased expression of retinoic acid-induced gene 1 in the dorsolateral prefrontal cortex in schizophrenia, bipolar disorder, and major depression

Haybaeck, Johannes; Postruznik, Magdalena; Miller, Christine L.; Dulay, Jeannette R.; Llenos, Ida C.; Weis, Serge

doi:10.2147/ndt.s72536

Cited by 26 publications

(16 citation statements)

References 75 publications

(86 reference statements)

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“…In accordance to these results a study on brains from patients with SZ, BD, or major depression demonstrates upregulation of the retinoic acid-inducible gene 1, indicating possible changes in signaling pathways such as retinoic acid pathway [47]. It has been also suggested that there is a relationship between affective disorders and retinoids.…”

Section: Cellular Response To Retinoic Acid and Retinoic Metabolismsupporting

confidence: 53%

Gene Expression Analysis of Fibroblasts from Patients with Bipolar Disorder

Logotheti¹,

Papadodima²

2016

J Neuropsychopharmacol Mental Health

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Bipolar disorder is a severe, lifelong psychiatric disease. The main underlying pathophysiology of the disease is still incomprehensible. Various studies have suggested that many genes of small impact in combination with environmental factors contribute to the expression of the disease. In this study comparative transcriptomic profiling to characterize skin fibroblasts' gene expression of bipolar disorder patients compared to healthy controls has been performed. Skin fibroblast cells from bipolar disorder patients (n=10) and marched healthy controls (n=5) have been cultured. RNA was extracted and then hybridized onto Illumina Human HT-12 v4 Expression BeadChips. Differentially expressed genes between bipolar disorder samples and healthy controls were identified by performing unequal t-test on log 2 transformed expression values. The resulting gene list was obtained by setting the p-value threshold to 0.05 and by removing genes that presented a fold change ≥ |0.5| (in log 2 scale). We concluded to 457 differentially expressed genes. Among them 127 showed an upregulation and 330 were downregulated. Τhe expression alterations of selected genes were validated by quantitative real-time polymerase chain reaction. In order to derive better insight into the biological mechanisms related to the differentially expressed genes, the lists of significant genes were subjected to pathway analysis and target prioritization indicating various processes such as calcium ion homeostasis, positive regulation of apoptotic process and cellular response to retinoic acid.

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Section: Cellular Response To Retinoic Acid and Retinoic Metabolismsupporting

confidence: 53%

Gene Expression Analysis of Fibroblasts from Patients with Bipolar Disorder

Logotheti¹,

Papadodima²

2016

J Neuropsychopharmacol Mental Health

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“…At the systems level, RA regulates cortical synchrony during sleep 66 , memory and cognitive behaviors [67][68][69] . In addition, aberrant RA signaling is associated with multiple psychiatric disorders including schizophrenia, bipolar disorder and depression in humans [70][71][72][73] . Because many psychiatric disorders are predisposed by aberrant brain development, understanding how RA functions in early postnatal brain development is important for determining the long-term consequences of the perturbations of this signaling pathway.…”

Section: Functional Implications Of Altered Pv Neuron Development In mentioning

confidence: 99%

“…At the systems level, RA regulates cortical synchrony during sleep (Maret et al, 2005), memory and cognitive behaviors (Chiang et al, 1998;Aoto et al, 2008;Nomoto et al, 2012). In addition, aberrant RA signaling is associated with multiple psychiatric disorders including schizophrenia, bipolar disorder and depression in humans (Goodman, 1998;Bremner et al, 2012;Qi et al, 2015;Haybaeck et al, 2015).…”

Section: Functional Implications Of Altered Pv Neuron Development In mentioning

confidence: 99%

The thalamus regulates retinoic acid signaling and development of parvalbumin interneurons in postnatal mouse prefrontal cortex

Larsen

Proue

Christiansen

et al. 2018

Preprint

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GABAergic inhibitory neurons in the prefrontal cortex (PFC) play a crucial role in higher cognitive functions. Although disruption of their normal development is linked to a number of psychiatric disorders, cellular and molecular mechanisms underlying the normal development of these neurons are poorly understood. Here we found that during postnatal mouse development, Cyp26b1, a gene encoding a retinoic acid-degrading enzyme, is strongly expressed in the PFC and that medial ganglionic eminence (MGE)- show that the thalamus regulates the development of PFC interneurons both by cortexwide and area-specific mechanisms.

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“…These regions include the hippocampus, insula, prefrontal cortex, and inferior parietal cortex [38,41]. Genetic research has also provided some evidence related to the pathogenesis of both schizophrenia and depression, including retinoic acid-inducible or induced gene 1, the a-1C subunit of the L-type voltage-gated calcium channel, and immune genes [42][43][44][45]. These convergent findings may explain the relatively lower accuracy in the classification of FES and MDD in this study.…”

Section: Discussionmentioning

confidence: 56%

Neurocognitive Graphs of First-Episode Schizophrenia and Major Depression Based on Cognitive Features

et al. 2017

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Neurocognitive deficits are frequently observed in patients with schizophrenia and major depressive disorder (MDD). The relations between cognitive features may be represented by neurocognitive graphs based on cognitive features, modeled as Gaussian Markov random fields. However, it is unclear whether it is possible to differentiate between phenotypic patterns associated with the differential diagnosis of schizophrenia and depression using this neurocognitive graph approach. In this study, we enrolled 215 first-episode patients with schizophrenia (FES), 125 with MDD, and 237 demographically-matched healthy controls (HCs). The cognitive performance of all participants was evaluated using a battery of neurocognitive tests. The graphical LASSO model was trained with a one-vs-one scenario to learn the conditional independent structure of neurocognitive features of each group. Participants in the holdout dataset were classified into different groups with the highest likelihood. A partial correlation matrix was transformed from the graphical model to further explore the neurocognitive graph for each group. The classification approach identified the diagnostic class for individuals with an average accuracy of 73.41% for FES vs HC, 67.07% for MDD vs HC, and 59.48% for FES vs MDD. Both of the neurocognitive graphs for FES and MDD had more connections and higher node centrality than those for HC. The neurocognitive graph for FES was less sparse and had more connections than that for MDD. Thus, neurocognitive graphs based on cognitive features are promising for describing endophenotypes that may discriminate schizophrenia from depression.

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Increased expression of retinoic acid-induced gene 1 in the dorsolateral prefrontal cortex in schizophrenia, bipolar disorder, and major depression

Cited by 26 publications

References 75 publications

Gene Expression Analysis of Fibroblasts from Patients with Bipolar Disorder

Gene Expression Analysis of Fibroblasts from Patients with Bipolar Disorder

The thalamus regulates retinoic acid signaling and development of parvalbumin interneurons in postnatal mouse prefrontal cortex

Neurocognitive Graphs of First-Episode Schizophrenia and Major Depression Based on Cognitive Features

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