Increased expression of the prolactin receptor is associated with malignant laryngeal tumors

González-Lucano, Luis Renee; Muñoz‐Valle, José Francisco; Ascencio-Cedillo, Rafael; Domı́nguez-Rosales, José Alfredo; López-Rincón, Gonzalo; Toro-Arreola, Susana del; Bueno-Topete, Miriam Ruth; Daneri-Navarro, ́Adrián; Estrada-Chávez, Ciro; Pereira‐Suárez, Ana Laura

doi:10.3892/etm.2012.464

Cited by 11 publications

(9 citation statements)

References 30 publications

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“…A previous study of our research group showed the relation of high PRLR expression and malignant laryngeal tumors (22).…”

Section: Introductionmentioning

confidence: 77%

“…There is an association between PRL and its receptor's overexpression with the development of different types of cancer such as breast, laryngeal, prostate, colon and cervical cancer (22,23,(32)(33)(34)(35)(36). The role of circulating PRL in tumorigenesis, mainly in breast cancer, has been a topic of debate for more than 20 years since various epidemiological studies were unable to reach unified conclusions on the correlation between circulating PRL levels and risk for cancer (37,38).…”

Section: Introductionmentioning

confidence: 99%

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A 60 kDa prolactin variant secreted by cervical cancer cells modulates apoptosis and cytokine production

et al. 2018

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Abstract. Prolactin (PRL) is associated with different types of cancer, such as cervical cancer. Recombinant PRL has antiapoptotic effect on cervical cancer cells, and it can also induce cytokine production on macrophages. A 60 kDa variant of PRL is produced by cervical cancer cells. The aim of the present study was to evaluate this variant's bioactivity, to test its effect on cervical cancer cell apoptosis, and to assess its ability to induce cytokine production on THP-1 macrophages. First, 60 kDa PRL was isolated and used to stimulate Nb2 cells. Later, apoptosis was measured after exposure to 60 kDa PRL. Finally, cytokines were measured on THP-1 stimulated supernatants. Our results show that 60 kDa PRL increased Nb2 cell proliferation. Apoptosis was decreased after stimuli with 60 kDa PRL in cervical cancer cells. IL-1β and TNF-α are produced by THP-1 macrophages after stimuli. These results suggest that 60 kDa PRL produced by cervical cancer cells is able to reduce apoptosis in HeLa, SiHa and C-33A cells and induce IL-1β and TNF-α production by THP-1 macrophages.

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“…A previous study of our research group showed the relation of high PRLR expression and malignant laryngeal tumors (22).…”

Section: Introductionmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

A 60 kDa prolactin variant secreted by cervical cancer cells modulates apoptosis and cytokine production

et al. 2018

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“…Following the guidelines of the Bethesda System, we included 11 biopsies from tissues characterized as low-grade squamous intraepithelial lesions (LSIL) and 23 high-grade squamous intraepithelial lesions (HSIL). We also included 21 uterine cervical cancer (UCC) samples classified as epidermoid [11] or adenocarcinomas [2], which were analyzed by immunohistochemistry and Western blot.…”

Section: Patients and Tissue Samplesmentioning

confidence: 99%

“…During the last 10 years several experimental and clinical studies have shown altered expression of PRL/PRLR in human tumors such as mammary, prostate, endometrial and laryngeal tumors [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Prolactin and Prolactin Receptor Expression in Cervical Intraepithelial Neoplasia and Cancer

Ascencio-Cedillo

López-Pulido

Muñoz‐Valle

et al. 2014

Pathol. Oncol. Res.

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Prolactin receptor (PRLR) overexpression could play a role in tumorigenesis. The aim of this study was to determine prolactin (PRL) and PRLR expression in biopsies from patients with precursor lesions and uterine cervical cancer. PRLR expression was analyzed in 63 paraffin-embedded biopsies of uterine cervical tissue. In total, eleven low-grade squamous intraepithelial lesions (LSIL), 23 high-grade squamous intraepithelial lesions (HSIL), 21 uterine cervical cancers (UCC) and 8 normal epithelium (NE) were examined using immunoperoxidase staining and Western blot analysis. Additionally, PRL expression was identified in human cervical cancer serum and tissues. The PRLR expression was found to be significantly increased in cervical cancer in comparison with normal tissue and precursor lesions (P < 0.0003). The presence of the long isoform of the PRLR was observed only in cervical cancer tissues. Serum PRL levels were normal in all samples and local prolactin expression was similar in precursor lesions and cervical cancer by Western blot analysis. Our data suggest a possible role for PRLR in the progression of cervical cancer.

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“…In their study, Soroush et al detected prolactin elevation in 76.6% of patients with colorectal cancer and carcinoembryonic antigen (CEA) elevation in 59.6% of these patients, and they suggested that prolactin may be used as a better tumor marker in colorectal cancer patients compared to CEA (20). Some cancer types stated to have a potential prolactin effect on tumor development are hepatocellular carcinoma (21), malignant laryngeal tumors (22), tongue cancers (23), cervical cancers (5), ovarian cancers (24), and endometrial cancers (24). There have been studies indicating that prolactin is a valuable tumor marker, yet there have also been studies indicating the contrary (20).…”

Section: Discussionmentioning

confidence: 99%

Differentiated thyroid cancer in patients with prolactinoma

et al. 2016

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Background/aim: Increasing evidence is available about the role of prolactin in the development of various cancers. The purpose of this study is to evaluate the frequency of thyroid cancer in patients with prolactinoma followed at a single site. Materials and methods:The medical records of 182 patients diagnosed with prolactinoma were reviewed retrospectively. Serum prolactin, antithyroglobulin, antithyroid peroxidase antibody, thyroid-stimulating hormone, free T4, and free T3 values and pituitary gland magnetic resonance imaging and thyroid ultrasound reports were evaluated.Results: Forty-five (39.5%) patients were found to have a thyroid nodule (13 solitary, 32 multiple). Ten patients were administered a thyroidectomy, and differentiated thyroid cancer (DTC) was detected in 6 of these patients (6/114, 5.3%). One patient had lung metastasis. The control group consisted of 113 individuals (101 females, 12 males with a mean age of 32.1 ± 9.1). In the ultrasound reports, 28 of these individuals (24.8%) had a thyroid nodule (5 solitary, 23 multiple), and one individual (1/113, 0.8%) had DTC. Conclusion:When compared to the control group, thyroid volume and thyroid nodularity were significantly higher in patients with prolactinoma (P < 0.001, P = 0.018, respectively); however, no statistically significant difference existed for the incidence of thyroid cancer (P = 0.196).

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Increased expression of the prolactin receptor is associated with malignant laryngeal tumors

Cited by 11 publications

References 30 publications

A 60 kDa prolactin variant secreted by cervical cancer cells modulates apoptosis and cytokine production

A 60 kDa prolactin variant secreted by cervical cancer cells modulates apoptosis and cytokine production

Prolactin and Prolactin Receptor Expression in Cervical Intraepithelial Neoplasia and Cancer

Differentiated thyroid cancer in patients with prolactinoma

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