Increased expression of type 1 cannabinoid (CB1) receptor among patients with rotator cuff lesions and shoulder stiffness

Kuo, Sheng‐Fong; Wang, Feng‐Sheng; Ko, Jih‐Yang; Tang, Chih‐Hsin; Siu, Ka-Kit; Hsu, Ya-Hung; Tsai, Tsai-Chen

doi:10.1016/j.jse.2017.09.010

Cited by 7 publications

(7 citation statements)

References 12 publications

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“…However, the biological reasons for this association remain unknown. An inflammatory cascade involving synovial cells and capsular fibroblasts and resulting in fibrosis s likely to lie behind the development of SS, with recent studies confirming the presence of several inflammatory mediators within the joints of patients with SS 9,30,31,34 . This inflammatory-fibrotic cascade is triggered by over-expression of transforming growth factor-beta (TGF-β), tumor necrosis factor-alpha (TNF-α) and other cytokines 36,37 , and leads first to a fibroblastic hyperplasia of the synovium, then to a phenotypic shift of fibroblasts to myofibroblasts and an imbalance in matrix metalloproteinases (MMPs) homeostasis; this eventually leads to the alterations of the connective tissue in the glenohumeral capsule typical of the final stage of the disease 36 .…”

Section: Discussionmentioning

confidence: 98%

The presence of gastroesophageal reflux disease increases the risk of developing postoperative shoulder stiffness after arthroscopic rotator cuff repair

Cucchi

Menon

Feroldi

et al. 2020

Journal of Shoulder and Elbow Surgery

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Section: Discussionmentioning

confidence: 98%

The presence of gastroesophageal reflux disease increases the risk of developing postoperative shoulder stiffness after arthroscopic rotator cuff repair

Cucchi

Menon

Feroldi

et al. 2020

Journal of Shoulder and Elbow Surgery

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“…By summation of the measured ROM, the sum of range of motion (SROM) was obtained [ 12 ]. Shoulder stiffness was defined by loss of more than 50% of range of motion in any direction or the SROM < 270° [ 24 ]. The clinical parameters were assessed before and 1 week, 4 weeks, 3 months, 6 months, and 12 months after intervention.…”

Section: Methodsmentioning

confidence: 99%

The Therapeutic Effects of Extracorporeal Shock Wave Therapy (ESWT) on the Rotator Cuff Lesions with Shoulder Stiffness: A Prospective Randomized Study

Siu

Wang

et al. 2020

BioMed Research International

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Aim. We wish to investigate the therapeutic potential of a single-session high-energy extracorporeal shock wave therapy (ESWT) on the rotator cuff lesions with shoulder stiffness. Patients and Methods. Thirty-seven patients afflicted with rotator cuff lesions with shoulder stiffness were randomized to receive either shockwave or sham treatment based on statistical randomization. In the shockwave group, we used Orthospec™ Extracorporeal Shock Wave Therapy 3000 impulse 24 kV (0.32 mJ/mm2) focused at two points as one session. The sham intervention entailed the use of the device in which the silicone pad was removed from the stand-off device. The visual analogue scale (VAS), muscle power of the shoulder, Constant and Murley score (CMS), and range of motion (ROM) of the shoulder were assessed for all patients. Ten milliliters of peripheral venous blood was obtained from every participant for the measurements of markers for inflammation, tissue regeneration, angiogenesis, and substance P before and at 1 week and 4 weeks after intervention. Results. The ESWT group has significantly better VAS, muscle power, CMS, and ROM at 6 and 12 months after intervention. No between-group differences were observed before as well as 1 and 4 weeks after intervention in the selected biomarkers. Conclusion. ESWT may be a good adjuvant for the treatment of rotator cuff lesions with shoulder stiffness.

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“…Patients were deemed to have SS if total ROM was <270°. We have been employed these criteria in the serial studies published by our team [ 3 , 18 ].…”

Section: Methodsmentioning

confidence: 99%

“…Tissues were ground under liquid nitrogen free from RNAase, and the total RNA was extracted by an RNA purification kit (RiboPure, Thermo Fisher Scientific). One microgram of extracted RNA was reverse-transcribed into complementary DNA (Step One Real-Time PCR System; Thermo Fisher Scientific) following the manufacturer’s instructions [ 3 ]. The threshold cycle (Ct) was determined as the cycle number when the fluorescence signal became identifiable.…”

Section: Methodsmentioning

confidence: 99%

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Decreased Expression of Leptin among Patients with Shoulder Stiffness

Chen

et al. 2022

Life

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Shoulder stiffness (SS) is a disease that is fibroblastic and inflammatory in nature. Leptin is an adipokine-mediating the fibroblastic and inflammatory processes of various diseases. Our study tried to investigate the role of leptin in SS pathogenesis. Subacromial bursa from stiff and non-stiff shoulders were obtained for reverse transcription-polymerase chain reaction (RT-PCR) analysis and immunoblotting. Subacromial fluid was obtained for enzyme-linked immunosorbent assay. We showed that the expression level of leptin was lower in the subacromial bursae from the stiff shoulders in RT-PCR analysis (p < 0.001) and immunoblotting (p < 0.001). The concentration of leptin was also lower in the subacromial fluid derived from stiff shoulders. The leptin level in the subacromial fluid was positively associated with the constant score, total range of motion, flexion, abduction, and external rotation. The synovial fibroblasts derived from stiff shoulder-retrieved subacromial bursa were treated by 0, 1, and 3 μM leptin. Under RT-qPCR analysis, leptin was shown to dose-dependently decrease the transcription of IL-6, IL-10, and IL-13, but without impact on IL-1β and IL-4 (p < 0.001, p = 0.001, p = 0.001, p = 0.137, and p = 0.883 by ANOVA test, respectively). These results shed light on the role of leptin in orchestrating the disease processes of SS.

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Increased expression of type 1 cannabinoid (CB1) receptor among patients with rotator cuff lesions and shoulder stiffness

Cited by 7 publications

References 12 publications

The presence of gastroesophageal reflux disease increases the risk of developing postoperative shoulder stiffness after arthroscopic rotator cuff repair

The presence of gastroesophageal reflux disease increases the risk of developing postoperative shoulder stiffness after arthroscopic rotator cuff repair

The Therapeutic Effects of Extracorporeal Shock Wave Therapy (ESWT) on the Rotator Cuff Lesions with Shoulder Stiffness: A Prospective Randomized Study

Decreased Expression of Leptin among Patients with Shoulder Stiffness

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