Increased Expression of Valosin-Containing Protein (p97) Is Correlated With Disease Recurrence in Follicular Thyroid Cancer

Abstract

The prognostic utility of VCP expression in FTC was demonstrated.

Interaction between Salt-inducible Kinase 2 (SIK2) and p97/Valosin-containing Protein (VCP) Regulates Endoplasmic Reticulum (ER)-associated Protein Degradation in Mammalian Cells

“…The current results, demonstrating that the interaction between SIK2 and p97/VCP regulates ERAD, supports the possibility that SIK2, like p97/VCP, may serve as a key regulator in the ubiquitin-proteasome system and autophagy. Furthermore, this regulatory network may have significant implications in cancer biology as previous reports have shown that elevated p97/VCP levels correlate with metastasis of several types of cancers (55)(56)(57)(58) and that SIK2 is required for cancer cell growth (9). Collectively, these observations strengthen the notion that SIK2 is necessary for the proper functions and integrity of the ubiquitin-proteasome system and autophagy, which in turn are critical for cancer cell proliferation and survival.…”

Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy

“…Recent functional studies have confirmed the significance of the physical interactions [76]. p97 was also known to be overexpressed in multiple cancers [77-83], pointing to a possible addiction [84]. …”

Diverse functions with a common regulator: Ubiquitin takes command of an AAA ATPase

“…In humans, its expression level was found to be elevated in certain types of cancer tissues (Yamamoto et al, 2004a(Yamamoto et al, , 2005. The protein is mainly localized in the cytosol, but a signiWcant fraction is associated with membranes of various organelles such as the endoplasmic reticulum (ER) and the Golgi (Acharya et al, 1995;Latterich et al, 1995;Rabouille et al, 1995).…”